Automated digital design for 3D-printed individualized therapies

Eleftheriadis, Georgios K.; Kantarelis, Efthymios; Monou, Paraskevi Kyriaki; Andriotis, Eleftherios G.; Bouropoulos, Nikolaos; Tzimtzimis, Emmanouil K.; Tzetzis, Dimitrios; Rantanen, Jukka; Fatouros, Dimitrios G.

doi:10.1016/j.ijpharm.2021.120437

Cited by 26 publications

(14 citation statements)

References 45 publications

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“…Furthermore, in 2021, the FDM 3D printer was investigated in another study to produce the individualized cannabidiol ODFs. This study proposed a method for promoting automation in the manufacturing of personalized medicines [22]. In another study by Elbl et al [23], the multilayered ODF maltodextrin films of benzydamine hydrochloride were successfully fabricated using an in-house modified syringe extrusion 3D printer.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

Panraksa

Udomsom

et al. 2021

Polymers

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The application of hydrophilic polymers in designing and three-dimensional (3D) printing of pharmaceutical products in various dosage forms has recently been paid much attention. Use of hydrophilic polymers and syringe extrusion 3D printing technology in the fabrication of orodispersible films (ODFs) might hold great potential in rapid drug delivery, personalized medicine, and manufacturing time savings. In this study, the feasibility of 3D-printed ODFs fabrication through a syringe extrusion 3D printing technique and using five different hydrophilic polymers (e.g., hydroxypropyl methylcellulose E15, hydroxypropyl methylcellulose E50, high methoxyl pectin, sodium carboxymethylcellulose, and hydroxyethylcellulose) as film-forming polymers and printing materials has been investigated. Rheology properties and printability of printing gels and physicochemical and mechanical properties of 3D-printed ODFs were evaluated. Amongst the investigated hydrophilic polymers, sodium carboxymethylcellulose at a concentration of 5% w/v (SCMC-5) showed promising results with a good printing resolution and accurate dimensions of the 3D-printed ODFs. In addition, SCMC-5 3D-printed ODFs exhibited the fastest disintegration time within 3 s due to high wettability, roughness and porosity on the surface. However, the results of the mechanical properties study showed that SCMC-5 3D printed ODFs were rigid and brittle, thus requiring special packaging to prevent them from any damage before practical use.

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Section: Introductionmentioning

confidence: 99%

Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

Panraksa

Udomsom

et al. 2021

Polymers

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“…The algorithm processes the appropriate input data, i.e., the suggested therapeutic plan and the available feedstock properties, and generates the optimal digital design of the medicinal product. Afterwards, the generated design can be loaded to the 3D printer by a medical doctor, a pharmacist, or a patient in order to proceed with manufacturing of a personalized dosage form [79]. The algorithm processes the appropriate input data, i.e., the suggested therapeutic plan and the available feedstock properties, and generates the optimal digital design of the medicinal product.…”

Section: Critical Discussionmentioning

confidence: 99%

The Advent of a New Era in Digital Healthcare: A Role for 3D Printing Technologies in Drug Manufacturing?

et al. 2022

Self Cite

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The technological revolution has physically affected all manufacturing domains, at the gateway of the fourth industrial revolution. Three-dimensional (3D) printing has already shown its potential in this new reality, exhibiting remarkable applications in the production of drug delivery systems. As part of this concept, personalization of the dosage form by means of individualized drug dose or improved formulation functionalities has concentrated global research efforts. Beyond the manufacturing level, significant parameters must be considered to promote the real-time manufacturing of pharmaceutical products in distributed areas. The majority of current research activities is focused on formulating 3D-printed drug delivery systems while showcasing different scenarios of installing 3D printers in patients’ houses, hospitals, and community pharmacies, as well as in pharmaceutical industries. Such research presents an array of parameters that must be considered to integrate 3D printing in a future healthcare system, with special focus on regulatory issues, drug shortages, quality assurance of the product, and acceptability of these scenarios by healthcare professionals and public parties. The objective of this review is to critically present the spectrum of possible scenarios of 3D printing implementation in future healthcare and to discuss the inevitable issues that must be addressed.

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“…At its inception, 3DP resulted in a burst of innovation, promise, and action, followed by a realisation of the challenges of its widespread adoption [1][2][3][4]. Significant interest around pharmaceutical 3DP began towards the turn of the century, at a time when the paradigm was the conventional, large-scale mass manufacturing of identical dosage forms [5][6][7].…”

Section: Moving 3dp Of Pharmaceuticals Beyond the Laboratory And Into The Clinicmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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Automated digital design for 3D-printed individualized therapies

Cited by 26 publications

References 45 publications

Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

The Advent of a New Era in Digital Healthcare: A Role for 3D Printing Technologies in Drug Manufacturing?

Disrupting 3D printing of medicines with machine learning

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