Automated macular segmentation with spectral domain optical coherence tomography in the fellow eyes of patients with unilateral retinal vein occlusion

Çetin, Ebru; Bozkurt, Kerem; Parca, Osman; Pekel, Gökhan

doi:10.1007/s10792-018-1039-3

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…Therefore, although there are certain differences in each of the risk factors, they may share the same processes that cause the subclinical in ammation with the production of reactive oxygen species and cytokines, microvascular endothelium damage as well as leukostasis, eventually leading to local tissue hypoxia and capillary non-perfusion [3,[20][21][22].…”

Section: Discussionmentioning

confidence: 99%

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Analysis of ganglion cell-inner plexiform layer thickness in retinal vein occlusion with resolved macular edema

Zheng

Yang

et al. 2022

Int Ophthalmol

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Purpose. To analyze the retinal ganglion cell-inner plexiform layer (GCIPL) changes in retinal vein occlusion (RVO) eyes with resolved macular edema using optical coherence tomography. Methods.We compared the average and minimum GCIPL thickness in RVO eyes with fellow eyes and healthy controls including 40 unilateral RVO patients and 48 healthy subjects. The average GCIPL thickness in BRVO eyes was segmented into the affected and opposite area according to the site of lesion, comparing them with corresponding areas in fellow eyes. Furthermore, maximum central macular thickness (CMT), visual acuity (VA), and intravitreal injection times were recorded to investigate their relationship with the GCIPL thickness.Results.Despite no signi cant difference in CMT (P = 0.96), the average (P = 0.02 and P < 0.001, respectively) and minimum (both P < 0.001) GCIPL thickness were decreased in RVO eyes with resolved macular edema after treatment in comparison to fellow eyes and healthy eyes. Maximum CMT thickness was negatively correlated with the minimum GCIPL thickness (r = -0.47, P = 0.003). VA and average GCIPL thickness were associated (rs = -0.49, P = 0.002). In a subgroup analysis only included BRVO patients, the opposite area revealed no signi cant difference between two eyes (P = 0.91) although the affected area in BRVO eyes was decreased (P < 0.001).Conclusions. A decrease of GCIPL thickness in RVO was observed even after anatomic restoration and associated with VA prognosis. These GCIPL defects could be attributable to systemic risks and RVO itself, not anti-VEGF effects.

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Section: Discussionmentioning

confidence: 99%

“…RVO is the second most common retinal vascular disorder usually leading to severe loss of visual function with characteristic macular edema and retinal hemorrhage [1][2][3]. It can be roughly classi ed as branch RVO (BRVO) and central RVO (CRVO) according to anatomical location of vascular occlusion.…”

Section: Introductionmentioning

confidence: 99%

Analysis of ganglion cell-inner plexiform layer thickness in retinal vein occlusion with resolved macular edema

Zheng

Yang

et al. 2022

Int Ophthalmol

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“… 15 , 16 , 17 In literature, there are studies evaluating the fellow eyes of patients with unilateral RVO with electrophysiologic tests, microperimetry, and retina layer thickness measurements. 10 , 18 , 19 , 20 , 21 Additionally, a limited number of angiographic studies were done to reveal retinal or choroidal vascular changes in the fellow eye using UWFFA in BRVO patients, adaptive optics scanning light ophthalmoscope fluorescein angiography in CRVO patients, and OCTA in RVO patients. 22 , 23 , 24 , 25 , 26 However there is no study evaluating both peripheral and central subtle vascular changes in the fellow eyes of unilateral RVO patients at the same time.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Central and Peripheral Retinal Vascular Changes in the Fellow Eyes of Patients with Unilateral Retinal Vein Occlusions

Ertop,

Yaylacıoğlu Tuncay,

Arıbaş

et al. 2023

tjo

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Objectives: To evaluate the subtle peripheral retinal and macular vascular changes in the fellow eyes of patients with unilateral retinal vein occlusion (RVO). Materials and Methods: This retrospective study included 53 patients with unilateral RVO and 44 age-matched controls. The frequency of peripheral retinal vascular pathologies in both eyes was evaluated using high quality ultra-wide field fluorescein angiography (UWFFA). Macular vascular density, flow area, and foveal avascular zone measurements from optical coherence tomography angiography (OCTA) were analyzed together with laser flare photometry values in patients and controls. Results: Peripheral retinal vascular pathologies were detected on UWFFA in the fellow eyes of 36 (67.9%) patients. No significant central vascular pathologies were detected on OCTA and there was no significant difference in OCTA parameters between the fellow eyes and the controls. Flare values did not differ significantly between the control and the fellow eyes. Conclusion: Two thirds of the fellow eyes of unilateral RVO patients had subtle peripheral retinal vascular changes, while there was no significant microvascular change detected with OCTA in the macula. This suggests that vascular changes caused by systemic vascular disorders probably first start in the peripheral retina of the fellow eyes of patients with RVO.

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Subclinical inner retinal layer thickness changes in the fellow eyes of patients with unilateral central retinal artery occlusion: a pilot study

Mirza

Oltulu

et al. 2020

Int Ophthalmol

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Automated macular segmentation with spectral domain optical coherence tomography in the fellow eyes of patients with unilateral retinal vein occlusion

Cited by 5 publications

References 14 publications

Analysis of ganglion cell-inner plexiform layer thickness in retinal vein occlusion with resolved macular edema

Analysis of ganglion cell-inner plexiform layer thickness in retinal vein occlusion with resolved macular edema

Evaluation of Central and Peripheral Retinal Vascular Changes in the Fellow Eyes of Patients with Unilateral Retinal Vein Occlusions

Subclinical inner retinal layer thickness changes in the fellow eyes of patients with unilateral central retinal artery occlusion: a pilot study

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