Automated method to determine pharmaceutical compounds in wastewater using on-line solid-phase extraction coupled to LC-MS/MS

Júnior, César Augusto Marasco; Silva, Bianca Ferreira da; Lamarca, Rafaela Silva; Gomes, Paulo Clairmont Feitosa de Lima

doi:10.1007/s00216-021-03481-7

Cited by 11 publications

(6 citation statements)

References 48 publications

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“…The limits of detection and quantification (LOQ) were estimated using the ratio of the blank standard deviation or the linear coefficient between the slope value of 3.3 and 10, respectively. Furthermore, for the LOQ (first point of the calibration curve), a relative standard deviation of less than 20% was adopted as an additional criterion to guarantee the reliability and quality of the results [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of green coffee bean flour fortification on the chemical and nutritional properties of gluten-free cake

et al. 2022

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The objective of this study was the application of green coffee bean flour in gluten-free cakes with different percentages (4, 8 and 15% (w/w)), to evaluate the optimal value for fortification, and the products were characterized based on their centesimal composition and bioactive compounds (caffeine and total phenolic compounds). Significant differences ( p ≤ 0.05) were observed in the content of lipids, total dietary fiber, insoluble fiber, energy values, sodium, caffeine, and total phenolics, mainly in the product in which 15% (w/w) green coffee bean flour was added. Caffeine content was only detected and quantified in products with > 8% (w/w) green coffee bean flour, whereas the total phenolic content was detected and quantified in products with > 4% (w/w) green coffee bean flour. Thus, fortification of these products with 15% green coffee bean flour promoted a higher content of total dietary fiber and lower content of lipids, calories, sodium, and increased bioactive compounds. Thus, green coffee bean flour is an excellent alternative for the production of innovative foods.

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Section: Methodsmentioning

confidence: 99%

Effects of green coffee bean flour fortification on the chemical and nutritional properties of gluten-free cake

et al. 2022

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“…To investigate static adsorption, MMIPs or MNIPs (50 mg) were suspended in solutions (50 mL) of methcathinone with different concentrations (1-10 mg mL −1 ) and then shaken for 12 h at 35 °C. To examine the dynamic adsorption, MMIPs or MNIPs (50 mg) were suspended in 50 mL of methcathinone solution (2 mg mL −1 ) and incubated at 35 °C for different times (1,3,5,10,20,30,60,90,120, and 180 minutes). Subsequently, aer treatment with magnetic separation and enrichment, the adsorption capacity was calculated by analyzing the amount of methcathinone in the samples before and aer adsorption according to LC-MS/MS.…”

Section: Single and Competitive Batch Adsorption Testsmentioning

confidence: 99%

“…For example, Jin et al achieved quantitative analysis of abused substances in sewage based on SPE-LC-MS/ MS, demonstrating that the sensitivity of the method could be enhanced several times by the enrichment of SPE. 5,6 However, the method requires signicant amounts of energy for activation and elution, accurate control of ow rate and prolonged drying process, which makes enrichment process cumbersome, time-consuming (lasting several hours) and lacking in selectivity.…”

Section: Introductionmentioning

confidence: 99%

Trace detection of methcathinone in sewage using targeted extraction based on magnetic molecularly imprinted polymers coupled with liquid chromatography-tandem mass spectrometry

Ling,

Zhang,

Xiang

et al. 2023

Anal. Methods

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“…This integration does not necessarily mean the miniaturization of the system but rather how an analytical procedure is done [ 65 ]. On the other hand, hyphenation is an on-line blend between a chromatographic separation technique and one or more spectroscopic or spectrometric detection techniques leading to systems such as LC–MS, LC–MS/MS CE-MS, GC–MS, and LC-NMR [ 66 , 67 ].…”

Section: Integration Of Spe With Analytical Chromatographic Techniquesmentioning

confidence: 99%

“…Seawater was delivered to the SPE column via a quaternary pump and a six-port valve to switch between loading and elution to a UHPLC-MS/MS system. Marasco Júnior et al used a similar fashioned system of an Oasis HLB SPE column coupled to an LC–MS/MS system to determine pharmaceuticals in wastewater [ 66 ]. Most studies use similar setups resulting in high throughput, time-efficient, and less labor-intensive methods with improved speed and reliability [ 82 , 83 ].…”

Section: Integration Of Spe With Analytical Chromatographic Techniquesmentioning

confidence: 99%

A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis

et al. 2022

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Analytical processes involving sample preparation, separation, and quantifying analytes in complex mixtures are indispensable in modern-day analysis. Each step is crucial to enriching correct and informative results. Therefore, sample preparation is the critical factor that determines both the accuracy and the time consumption of a sample analysis process. Recently, several promising sample preparation approaches have been made available with environmentally friendly technologies with high performance. As a result of its many advantages, solid-phase extraction (SPE) is practiced in many different fields in addition to the traditional methods. The SPE is an alternative method to liquid–liquid extraction (LLE), which eliminates several disadvantages, including many organic solvents, a lengthy operation time and numerous steps, potential sources of error, and high costs. SPE advanced sorbent technology reorients with various functions depending on the structure of extraction sorbents, including reversed-phase, normal-phase, cation exchange, anion exchange, and mixed-mode. In addition, the commercial SPE systems are disposable. Still, with the continual developments, the restricted access materials (RAM) and molecular imprinted polymers (MIP) are fabricated to be active reusable extraction cartridges. This review will discuss all the theoretical and practical principles of the SPE techniques, focusing on packing materials, different forms, and performing factors in recent and future advances. The information about novel methodological and instrumental solutions in relation to different variants of SPE techniques, solid-phase microextraction (SPME), in-tube solid-phase microextraction (IT-SPME), and magnetic solid-phase extraction (MSPE) is presented. The integration of SPE with analytical chromatographic techniques such as LC and GC is also indicated. Furthermore, the applications of these techniques are discussed in detail along with their advantages in analyzing pharmaceuticals, biological samples, natural compounds, pesticides, and environmental pollutants, as well as foods and beverages. Graphical abstract

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Automated method to determine pharmaceutical compounds in wastewater using on-line solid-phase extraction coupled to LC-MS/MS

Cited by 11 publications

References 48 publications

Effects of green coffee bean flour fortification on the chemical and nutritional properties of gluten-free cake

Effects of green coffee bean flour fortification on the chemical and nutritional properties of gluten-free cake

Trace detection of methcathinone in sewage using targeted extraction based on magnetic molecularly imprinted polymers coupled with liquid chromatography-tandem mass spectrometry

A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis

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