Automated Parallel Dialysis for Purification of Polymers

Abstract

The implementation of a dialysis method for the simultaneous purification of different polymer materials in a commercially available automated parallel synthesizer (APS) is discussed. The efficiency of this “unattended” automated parallel dialysis (APD) method was investigated by means of proton nuclear magnetic resonance (1H-NMR) measurements, which confirmed that the method enables the removal of up to 99% of the unreacted monomer derived from the synthesis of the corresponding polymers in the APS. Size-exclusion chromatography (SEC) revealed that the molar mass and molar mass distribution of the investigated polymers did not undergo significant changes after the application of the APD method. The method discussed herein can be regarded as a good alternative to the “unattended” and reliable purification of polymer libraries prepared in APS. This method may be useful for overcoming current limitations of high-throughput/-output (HT/O) synthesis of polymer libraries, where purification of the generated materials currently represents a significant constraint for establishing fully automated experimental workflows necessary to advance towards a full digitalization of research and development of new polymers for diverse applications.

From monomer to micelle: a facile approach to the multi-step synthesis of block copolymers via inline purification

“…27 Terzioglu et al demonstrated, shortly aer, the strength of the dialysis method in an automated setup for high throughput screening for synthesising a polymer library using sophisticated parallel synthesis equipment. 28 For this work, a simple, comparatively cheap and reusable setup was built to produce multiblock copolymers via RAFT polymerization in a continuous ow process without the disturbing interference of residual monomers affecting the block copolymer delity. This approach solves the issues previously encountered by Baeten et al, 14 yet is much faster than any other Fig.…”

“… 27 Terzioğlu et al demonstrated, shortly after, the strength of the dialysis method in an automated setup for high throughput screening for synthesising a polymer library using sophisticated parallel synthesis equipment. 28 …”