Automated substance testing for lab-on-chip devices

Kloke, Lutz; Schimek, Katharina; Brincker, Sven; Lorenz, Alexandra; Jänicke, Annika; Drewell, Christopher; Hoffmann, Silke; Busek, Mathias; Sonntag, Frank; Danz, Norbert; Polk, Christoph; Schmieder, Florian; Borchanikov, Alexey; Artyushenko, Viacheslav; Baudisch, Frank; Bürger, Mario; Horland, Reyk; Lauster, Roland; Marx, Uwe

doi:10.1186/1753-6561-7-s6-p28

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“…This sensing device is coupled to the OPAL digital lock-in amplifier from COLIBRI PHOTONICS which calculates the amount of dissolved oxygen. Moreover a gantry robot can be used to position the sensor relatively to the microfluidic system [24].…”

Section: Oxygenatormentioning

confidence: 99%

Universal lab-on-a-chip platform for complex, perfused 3D cell cultures

et al. 2016

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The miniaturization, rapid prototyping and automation of lab-on-a-chip technology play nowadays a very important role. Lab-on-a-chip technology is successfully implemented not only for environmental analysis and medical diagnostics, but also as replacement of animals used for the testing of substances in the pharmaceutical and cosmetics industries. For that purpose the Fraunhofer IWS and partners developed a lab-on-a-chip platform for perfused cell-based assays in the last years, which includes different micropumps, valves, channels, reservoirs and customized cell culture modules. This technology is already implemented for the characterization of different human cell cultures and organoids, like skin, liver, endothelium, hair follicle and nephron. The advanced universal lab-on-a-chip platform for complex, perfused 3D cell cultures is divided into a multilayer basic chip with integrated micropump and application-specific 3D printed cell culture modules. Moreover a technology for surface modification of the printed cell culture modules by laser micro structuring and a complex and flexibly programmable controlling device based on an embedded Linux system was developed. A universal lab-on-a-chip platform with an optional oxygenator and a cell culture module for cubic scaffolds as well as first cell culture experiments within the cell culture device will be presented. The module is designed for direct interaction with robotic dispenser systems. This offers the opportunity to combine direct organ printing of cells and scaffolds with the microfluidic cell culture module. The characterization of the developed system was done by means of Micro-Particle Image Velocimetry (μPIV) and an optical oxygen measuring system

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Section: Oxygenatormentioning

confidence: 99%