Automated T2 quantitation in neuropsychiatric lupus erythematosus: A marker of active disease

Petropoulos, Helen; Sibbitt, Wilmer L.; Brooks, William M.

doi:10.1002/(sici)1522-2586(199901)9:1<39::aid-jmri5>3.0.co;2-8

Cited by 44 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other studies, brain abnormalities in NPSLE patients have been detected with other MRI techniques, such as H-MRS and spin-spin relaxation time measurements (34,(44)(45)(46)(47)(48). These various MRI techniques might reflect the same underlying histologic changes, different histologic aspects of the same pathologic process, or different pathologic processes.…”

Section: Resultsmentioning

confidence: 94%

Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus

Bosma¹,

Middelkoop²,

Rood³

et al. 2002

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To investigate the relationship between quantitative estimates of global brain damage based on magnetization transfer imaging (MTI) and cerebral functioning, as measured by neurologic, psychiatric, and cognitive assessments, as well as disease duration in patients with a history of neuropsychiatric systemic lupus erythematosus (NPSLE).Methods. In patients with systemic lupus erythematosus (SLE), neurologic, psychiatric, and psychological symptoms often occur. The frequency of nervous system involvement has been reported to range from 11% to 60% (1). Infection, drug side effects, hypertension, or metabolic derangements, as well as an intrinsic brain manifestation of SLE (i.e., neuropsychiatric SLE [NPSLE]), can cause such symptoms. The uncertain pathogenesis and the wide variety of manifestations of NPSLE complicate the development of a uniform diagnostic decision-making protocol and a uniform method of monitoring a patient with this type of SLE. Findings of routine brain imaging studies are often unremarkable in patients with NPSLE, or the studies reveal abnormalities, such as cerebral atrophy and white matter hyperintensities (on magnetic resonance imaging [MRI]), that can also be found in SLE patients without neuropsychiatric symptoms. Furthermore, no correlation has thus far been demonstrated between quantitative measures of such nonspecific abnormalities and measures of brain function (2-5).Recently, magnetization transfer ratio (MTR) histogram analysis, a quantitative MRI technique based on magnetization transfer imaging (MTI), was applied in patients with primary NPSLE but without abnormalities on MRI that could account for the clinical picture. With this technique, cerebral abnormalities were identified in these patients (6,7). Such abnormalities were found in SLE patients who had had episodes of neuropsychiatric symptoms in the past (chronic NPSLE) as well as in patients who were experiencing an active phase of neuropsychiatric symptoms (active NPSLE) (6,7). The

show abstract

Section: Resultsmentioning

confidence: 94%

Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus

Bosma¹,

Middelkoop²,

Rood³

et al. 2002

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…The T1-weighted images corresponding to the spectroscopic voxels were analyzed using automated k-means segmentation described previously (Petropoulos et al, 1999) to quantify CSF, white, and gray matter. The percentage of tissue within each spectroscopic voxel (CSF, gray, and white matter) was then calculated by creating a mask corresponding to each voxel location and superimposing this mask on the segmented images.…”

Section: Magnetic Resonance Studiesmentioning

confidence: 99%

Proton Magnetic Resonance Spectroscopy During Initial Treatment With Antipsychotic Medication in Schizophrenia

Bustillo

Rowland

Jung

et al. 2007

Neuropsychopharmacol

View full text Add to dashboard Cite

Reduced brain N-acetyl-aspartate (NAA) has been repeatedly found in chronic schizophrenia and suggests neuronal loss or dysfunction. However, the potential confounding effect of antipsychotic drugs on NAA has not been resolved. We studied 32 minimally treated schizophrenia patients and 21 healthy subjects with single-voxel proton magnetic resonance spectroscopy ( 1 H-MRS) of the frontal and occipital lobes, caudate nucleus, and cerebellum. Concentrations of NAA, Choline, and Cre were determined and corrected for the proportion of cerebrospinal fluid (CSF) in the voxel. Patients were treated in a randomized-controlled double-blind manner with either haloperidol or quetiapine. 1 H-MRS was repeated every 6 months for up to 2 years. There was a group main effect for baseline NAA with lower global NAA in schizophrenia subjects before treatment compared to healthy controls. Global NAA was directly related to measures of global cognitive performance in the whole subject sample. Following treatment with haloperidol or quetiapine, there were no changes in NAA in any of the regions studied. Early in the illness, schizophrenia patients already demonstrate subtle reductions in NAA. Treatment with typical or atypical antipsychotic medications for several months does not result in NAA changes.

show abstract

“…Spatial information is automatically classified into clusters based on statistical properties of each image pixel (Petropoulos, Sibbitt, & Brooks, 1999). Each output cluster represents a different tissue type (e.g., white matter, gray matter, and well as a small number of ''partial volume'' pixels comprised of both CSF and gray matter.…”

Section: Magnetic Resonance Imaging and Spectroscopymentioning

confidence: 99%

Myths of Neuropsychology: Intelligence, Neurometabolism, and Cognitive Ability

Jung

Yeo²,

Chiulli³

et al. 2000

The Clinical Neuropsychologist

Self Cite

View full text Add to dashboard Cite

Recently, Dodrill (1999) revised a previously described "Myth of neuropsychology" (1997) to state: "Just as below average performances on neuropsychological tests are found when intelligence is below average, to that same degree above average performances on neuropsychological tests are expected when intellectual abilities are above average." This study addresses the relationship between intellectual and neuropsychological performance in the context of Magnetic Resonance Spectroscopy (MRS) measurements of the neurometabolite N-acetylaspartate (NAA). When subjects were stratified by Full Scale IQ (Average, High Average, Superior) they differed significantly in terms of total neuropsychological performance [F(2,47) = 17.63; p <.001] and the neuronal marker NAA [F(2,47) = 3.25; p <.05]. Regression analysis across groups demonstrated that FSIQ and NAA were independently related to Total z-score [F(1,47) = 29.43; p <.0001] and accounted for over half the variance (r(2) of model =.56). The concurrent relationship of FSIQ and NAA to total neuropsychological performance suggests that the relationship between measures sensitive to intellectual ability and neuropsychological performance is real, and does not reflect arbitrary psychometric or scaling properties of the WAIS-III.

show abstract

Automated T2 quantitation in neuropsychiatric lupus erythematosus: A marker of active disease

Cited by 44 publications

References 28 publications

Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus

Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus

Proton Magnetic Resonance Spectroscopy During Initial Treatment With Antipsychotic Medication in Schizophrenia

Myths of Neuropsychology: Intelligence, Neurometabolism, and Cognitive Ability

Contact Info

Product

Resources

About