Automatic Determination of Aortic Compliance With Cine-Magnetic Resonance Imaging

Lalande, Alain; Kien, Philippe Khau Van; Salve, Nicolas; Salem, Douraı̈ed Ben; Legrand, Louis; Walker, Paul; Wolf, Jean-Éric; Brunotte, François

doi:10.1097/00004424-200212000-00008

Cited by 27 publications

(14 citation statements)

References 33 publications

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“…2). An automatic method to detect aortic contour on each image has already been described (18). This automatic postprocessing allows an automatic determination of the aortic compliance, avoiding manual tracing that could be time-consuming and induces significant inter-and intra-observer variability.…”

Section: Image Analysismentioning

confidence: 99%

Compliance and pulse wave velocity assessed by MRI detect early aortic impairment in young patients with mutation of the smooth muscle myosin heavy chain

Lalande

Kien

Walker

et al. 2008

Magnetic Resonance Imaging

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Purpose:To evaluate aortic elasticity with MRI on young asymptomatic individuals with mutation of the smooth muscle myosin heavy chain in whom aortic enlargement is not present. Materials and Methods:Aortic compliance, aortic distensibility, and pulse wave velocity (PWV) were semiautomatically measured from MRI in 8 asymptomatic subjects having a mutation of the MYH11 gene (Mϩ) and 21 nonmutated relatives (MϪ) of similar age, sex, and blood pressure characteristics.Results: Despite a similar aortic diameter in both groups, the aortic compliance and distensibility were significantly lower in Mϩ subjects compared with MϪ (0.84 Ϯ 0.33 versus 2.03 Ϯ 0.54 mm 2 /mmHg, 1.18 Ϯ 0.62 10 Ϫ3 versus 5.11 Ϯ 1.58 10 Ϫ3 mmHg Ϫ1 , respectively), and PWV was significantly higher (5.35 Ϯ 1.53 versus 3.60 Ϯ 0.64 m.s Ϫ1 ). A threshold aortic compliance value of 1.3 mm 2 /mmHg separated the two groups. The receiver operating characteristics curve analysis indicated an optimal threshold of 2.9 10 Ϫ3 mmHg Ϫ1 for aortic distensibility (sensitivity: 87.5%, specificity: 90%), and of 4.4 m.s Ϫ1 for PWV (sensitivity: 75%, specificity: 100%). Conclusion:Young asymptomatic adults with MYH11 mutation have an aortic compliance impairment which is not detectable by the sole measurement of the aortic size. Aortic compliance measurement might be part of routine examination in patients suspected of inherited aortic disease even with a normal aortic diameter.

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Section: Image Analysismentioning

confidence: 99%

Compliance and pulse wave velocity assessed by MRI detect early aortic impairment in young patients with mutation of the smooth muscle myosin heavy chain

Lalande

Kien

Walker

et al. 2008

Magnetic Resonance Imaging

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“…From the change in crosssectional area between systole and diastole and an estimate of the corresponding intra-arterial pressure difference, the distensibility can be calculated. The latter has been done using magnetic resonance imaging [10,11] and ultrasound [12,13]. Ultrasound suffers from the difficulty of imaging all parts of the aorta in a single view.…”

Section: Introductionmentioning

confidence: 99%

Age related changes of human aortic distensibility: evaluation with ECG-gated CT

et al. 2006

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Aortic distensibility is a parameter to grade vascular diseases and age-related effects because it is related to the elastic properties of the vessel wall. In this study vascular cross-sectional area changes have been determined using ECG-gated CT to analyse the age dependency of aortic distensibility. Distensibility measurements of the aorta were performed in 31 subjects (28 to 85 years). Time-resolved images were acquired either with a 4- or 16-detector row CT system using a modified CT angiography protocol. Cross-sectional area changes of the aorta were calculated by semiautomatic segmentation, and distensibility values were obtained using additional systemic blood pressure measurements. The aorta could be segmented successfully in all subjects. A decrease of aortic distensibility with age was found (r=0.50). Below (above) the renal arteries, the annual decrease was Delta D ( infrarenal ) =(-2.1+/-0.7).10(-7 )Pa(-1)a(-1), (D ( suprarenal ) Delta=(-3.5+/-1.1).10(-7 )Pa(-1)a(-1)). Differences between the ages, the youngest third and oldest third studied, were found to be significant (P( suprarenal )=0.003; P( infrarenal )=0.025). An age-dependent decrease of aortic wall elasticity can be determined in a modified routine CT angiography study.

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“…To obtain further insight into the possibility of subclinical vascular abnormalities, aortic compliance was measured in 48 individuals (42 asymptomatic, 6 TAA/ PDA) with MRI, a very precise, noninvasive technique. 23 Our results show that aortic stiffness is an early hallmark of the disease, occurring in all subjects harboring the disease haplotype compared with their normal relatives.…”

Section: Discussionmentioning

confidence: 55%

“…It was measured by MRI with automatic detection of the contour of the aorta over the whole cardiac cycle as previously described. 23 Ascending aorta was imaged in the transverse plane at the level of the pulmonary trunk with a cine MRI sequence (ECG-gated cine FISP sequence) with a repetition time of 15 milliseconds. Forty to 60 images of a single slice were acquired, thereby covering the whole cardiac cycle.…”

Section: Automatic Determination Of Aortic Compliance With Cine Mrimentioning

confidence: 99%

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Mapping of Familial Thoracic Aortic Aneurysm/Dissection With Patent Ductus Arteriosus to 16p12.2–p13.13

et al. 2005

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Background-Three loci have been shown to be responsible for nonsyndromic familial thoracic aortic aneurysms (TAAs) and aortic dissections (ADs). We recently described a large family in which TAA/AD associates with patent ductus arteriosus (PDA) and provided genetic arguments for a unique pathophysiological entity. Methods and Results-Genome-wide scan was performed in 40 subjects belonging to 3 generations in this large pedigree.Using the 7 TAA/AD cases as affected, we observed positive 2-point LOD scores on adjacent markers at chromosome 16p, with a maximum LOD score value of 2.73 at ϭ0, a value that increased to 3.56 when 5 PDA cases were included. Multipoint linkage analysis yielded a maximum LOD score of 4.14 in the vicinity of marker D16S3103. Fine mapping allowed the observation of recombinant haplotypes that delimited a critical 20-cM interval at 16p12.2-p13.13. Automatic determination of aortic compliance with cine MRI showed that all subjects bearing the disease haplotype, even asymptomatic, displayed a very low level of aortic compliance and distensibility. Aortic stiffness was strongly associated with disease haplotype with a marked effect of age, indicating subclinical and early manifestation of the disease. Conclusions-Genetic analysis of this family identified a unique locus responsible for both TAA/AD and PDA at chromosome 16p12.2-p13.13 with aortic stiffness as an early hallmark of the disease. TAA/AD with PDA is a new monogenic entity among the genetically heterogeneous group of TAA/AD disease.

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Automatic Determination of Aortic Compliance With Cine-Magnetic Resonance Imaging

Abstract: The aortic compliance can be obtained from a fuzzy logic based automatic contouring method, thereby avoiding the important interobserver variation often associated with manual tracing.

Cited by 27 publications

References 33 publications

Compliance and pulse wave velocity assessed by MRI detect early aortic impairment in young patients with mutation of the smooth muscle myosin heavy chain

Compliance and pulse wave velocity assessed by MRI detect early aortic impairment in young patients with mutation of the smooth muscle myosin heavy chain

Age related changes of human aortic distensibility: evaluation with ECG-gated CT

Mapping of Familial Thoracic Aortic Aneurysm/Dissection With Patent Ductus Arteriosus to 16p12.2–p13.13

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