Automatic differentiation of placental perfusion compartments by time-to-peak analysis in mice

Kording, Fabian; Forkert, Nils D.; Sedlacik, Jan; Adam, Gerhard; Hecher, Kurt; Arck, Petra C.; Remus, Chressen Catharina

doi:10.1016/j.placenta.2014.12.010

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…This model enabled separation of placental compartments, demonstrating high-flow and low-flow compartments in all placentas, and allowed quantification of mean perfusion values in each compartment separately ( Fig. 1 A) [6,7] . Placental perfusion has also been assessed using superparamagnetic iron oxide (SPIO) nanoparticles, and applied in a rat uterine artery ligation model of IUGR [8] .…”

Section: Perfusion Measurements Using Contrast Agentsmentioning

confidence: 99%

“…Development of complementary, non-invasive MRI tools capable of assessing placental function may improve diagnosis of pregnancy complications, such as intrauterine growth restriction (IUGR) and preeclampsia (PE), and potentially assist in decisions on the timing of delivery and on perinatal outcome. Over the past few years, a number of MRI methods were developed and employed to study placental function in animal studies and in the clinical settings, including perfusion measurements using Dynamic Contrast Enhanced MRI (DCE-MRI), in which T 1 is altered by intravenous administration of contrast agents [1–17] ; perfusion measurements using arterial spin labeling (ASL), in which the measured T 1 is affected by blood flow [18–23] ; oxygenation studies using blood oxygen level dependent (BOLD), in which T 2 * changes reflect changes in hemoglobin saturation [24–31] ; and oxygen enhanced (OE) T 1 [31] . Diffusion weighted MRI (DW MRI) [32–42] probes the microstructural properties of tissue by measuring the incoherent motion of water within the tissue.…”

Section: Introductionmentioning

confidence: 99%

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Functional MRI of the placenta – From rodents to humans

2015

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The placenta performs a wide range of physiological functions; insufficiencies in these functions may result in a variety of severe prenatal and postnatal syndromes with long-term negative impacts on human adult health. Recent advances in magnetic resonance imaging (MRI) studies of placental function, in both animal models and humans, have contributed significantly to our understanding of placental structure, blood flow, oxygenation status, and metabolic profile, and have provided important insights into pregnancy complications.

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Section: Perfusion Measurements Using Contrast Agentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional MRI of the placenta – From rodents to humans

2015

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“…Specifically, we evaluated perfusion in the two constituent regions of the murine placenta, the high perfusion zone (HPZ) on the fetal side of the placenta and the low perfusion zone (LPZ) on the maternal side of the placenta, at three gestational days (GD) of 13, 15, and 17. In previous works, these high and low perfusion zones have been identified in murine placentas using contrast enhanced ultrasound or MRI, based on their characteristic fast or slow uptake of contrast agents [29, 36, 37]. The HPZ roughly corresponds to the base of the labyrinth zone supplied by the maternal central canal (CC) and the LPZ roughly to the junctional zone.…”

Section: Introductionmentioning

confidence: 99%

A longitudinal study of placental perfusion using dynamic contrast enhanced magnetic resonance imaging in murine pregnancy

et al. 2016

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Introduction To evaluate changes in placental perfusion with advancing gestation in normal murine pregnancy using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Methods Seven timed-pregnant CD-1 mice underwent DCE-MRI scanning longitudinally on gestational days (GD) 13, 15, and 17. Placentas were segmented into high (HPZ) and low perfusion zones (LPZ) using tissue-similarity-mapping. Blood perfusion of the respective regions and the whole placenta was quantified using the steepest slope method. The diameter of the maternal central canal (CC) was also measured. Results An increase in perfusion was observed between GD13 and GD17 in the overall placenta (p=0.04) and in the HPZ (p=0.02). Although perfusion in the LPZ showed a slight increasing trend, it was not significant (p=0.07). Perfusion, in units of ml/min/100ml, in the overall placenta and the HPZ were, respectively, 61.2 ± 31.2 and 106.2 ± 56.3 at GD13 (n=19 placentas), 90.3 ± 43.7 and 139 ± 55.4 at GD15 (n=20), and 104.9 ± 76.1 and 172.2 ± 85.6 at GD17 (n=14). The size of the CC increased with advancing gestation (p<0.05). Discussion Using longitudinal DCE-MRI, the gestational age-dependent perfusion change in the normal murine placenta and in its regional compartments was quantified. In mid and late gestations, placental constituent regions differ significantly in their perfusion rates. The CC diameter also showed increase with advancing gestation, which may be playing an important role toward gestational age-dependent increase in placental perfusion.

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“…gadolinium chelate) has been used to quantify placental function such as blood volume, blood flow, oxygenation and perfusion rate in different placental compartments. 169 Recently, DCE-MRI has been used to investigate placental perfusion in hypoxic-induced FGR rodents, [170][171][172] pre-eclamptic rats (induced by continuous delivery of L-nitro-arginine methyl ester to chronically inhibit nitric oxide synthase) 173 and prenatal alcohol exposure in monkeys. 151 Placental blood flow and perfusion rate were reduced significantly in the animal models of hypoxia and ethanol exposure 151,170,171 but not in a model of pre-eclampsia.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Advances in imaging feto-placental vasculature: new tools to elucidate the early life origins of health and disease

Tongpob

Wyrwoll

2020

J Dev Orig Health Dis

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Optimal placental function is critical for fetal development, and therefore a crucial consideration for understanding the developmental origins of health and disease (DOHaD). The structure of the fetal side of the placental vasculature is an important determinant of fetal growth and cardiovascular development. There are several imaging modalities for assessing feto-placental structure including stereology, electron microscopy, confocal microscopy, micro-computed tomography, light-sheet microscopy, ultrasonography and magnetic resonance imaging. In this review, we present current methodologies for imaging feto-placental vasculature morphology ex vivo and in vivo in human and experimental models, their advantages and limitations and how these provide insight into placental function and fetal outcomes. These imaging approaches add important perspective to our understanding of placental biology and have potential to be new tools to elucidate a deeper understanding of DOHaD.

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Automatic differentiation of placental perfusion compartments by time-to-peak analysis in mice

Cited by 9 publications

References 27 publications

Functional MRI of the placenta – From rodents to humans

Functional MRI of the placenta – From rodents to humans

A longitudinal study of placental perfusion using dynamic contrast enhanced magnetic resonance imaging in murine pregnancy

Advances in imaging feto-placental vasculature: new tools to elucidate the early life origins of health and disease

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