Autonomic dysfunction in isolated rapid eye movement sleep without atonia

Barone, Daniel A.; Ebben, Matthew R.; Samie, Ashkan; Mortara, David; Krieger, Ana C.

doi:10.1016/j.clinph.2014.07.015

Cited by 22 publications

(11 citation statements)

References 44 publications

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“…11 RSWA, mentioned above as a core feature of RBD, has also been associated with autonomic dysfunction. Barone et al 12 reported that patients with isolated RSWA, which does not correspond to clinical RBD, also had decreased HRV compared to a control group. However, in a recent paper, HRV declined in patients with isolated RSWA compared to healthy controls, although the difference was not statistically significant.…”

Section: Introductionmentioning

confidence: 99%

Association of heart rate variability with REM sleep without atonia in idiopathic REM sleep behavior disorder

Yang

Choi

Lee

et al. 2021

Journal of Clinical Sleep Medicine

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Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD), characterized by rapid eye movement sleep without atonia (RSWA) and dream-enactment behavior, has been suggested to be a predictor of α-synucleinopathies. Autonomic instability, represented by heart rate variability, is a common characteristic of both iRBD and α-synucleinopathies. Previous studies reported that RSWA was associated with autonomic dysfunction and was a possible predictor of phenoconversion. Therefore, we sought to compare heart rate variability between iRBD and control groups and explore the relationship between heart rate variability and RSWA in patients with iRBD. Methods: Nocturnal polysomnographic data on 47 patients (28 men, 19 women) diagnosed with iRBD based on video-polysomnography and 26 age-matched and sex-matched controls were reviewed. The first 5-minute epoch with a stable electrocardiogram lead II on video-polysomnography was selected from stage N2, wake, and rapid eye movement. For quantification of RSWA, tonic activity was analyzed from the submentalis electromyogram and phasic activity from the submentalis and bilateral anterior tibialis electromyogram channels. Results: Compared to the control group, the iRBD group showed significant reductions in the standard deviation of the R-R intervals, the root mean square of successive R-R interval differences, and high-frequency values. Quantified tonic activity was inversely correlated with normalized low-frequency values and low-frequency/high-frequency ratios and positively correlated with normalized high-frequency values. Conclusions: This study implied decreased cardiac autonomic function in patients with iRBD, which showed parasympathetic predominance. Heart rate variability of the patients with iRBD in this study was associated with quantified tonic RSWA, which was previously reported to be a possible predictor of phenoconversion.

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Section: Introductionmentioning

confidence: 99%

Association of heart rate variability with REM sleep without atonia in idiopathic REM sleep behavior disorder

Yang

Choi

Lee

et al. 2021

Journal of Clinical Sleep Medicine

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“…Increased electromyography activity during REM sleep is partly linked to the nigrostriatal dopamine system, and hence, RBD is associated with dopamine function [6]. Evidences showed RBD can cause cognitive impairment [7], somatosensory impairment [8], autonomic dysfunction [9], and olfactory dysfunction [10] and reduced academic performance [11]. If untreated earlier, it could end up with death, with an evidence of 21% of mortality in a mean follow-up period of 7.1 years [12].…”

Section: Introductionmentioning

confidence: 99%

Self-Reported Rapid Eye Movement Sleep Behavior Disturbance and Its Associated Factors among Medicine and Health Science Students at the University of Gondar

Dagnew

Andualem

2020

BioMed Research International

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Introduction. Rapid eye movement sleep behavior disorder (RBD) is characterized by dream-enacting behavior (shouting, punching, and falling out of bed) related to unpleasant dreams and loss of normal rapid eye movement (REM) sleep muscle atonia. Rapid eye movement sleep enhances learning and memory by regulating neuronal synapses, and if it is undesirable, it can lead to cognitive impairment and poor academic performance and may end up with death. To the best of our searching databases, there is no such study conducted in Ethiopia. Therefore, this study is aimed at determining self-reported symptoms of RBD and its associated factors among the University of Gondar medicine and health science students (2019). Methods. We conducted a cross-sectional study from June 1 to July 2019, among medicine and health science students at the University of Gondar using a simple random sampling technique. A self-reported RBD screening questionnaire was used to collect the data. We used Epi Info™ 7.0.8.3 and Stata 14 for data entry and statistical analyses, respectively. Descriptive statistics (frequency with percent and mean with standard deviation) and adjusted odds ratio (AOR) with 95% uncertainty interval (UI) were computed. In a multivariable binary logistic regression, variables with a p<0.05 were declared as significant. Results. Three hundred and eighty-seven students took part in the study. The mean age of participants was 20.81 (±1.83) years. The prevalence of self-reported RBD was 46.25% [95% UI (41.26%-51.24)]. Physical exercise immediately before sleep (AOR=2.50, 95% UI (1.24-5.02)), using Facebook immediately before sleep (AOR=1.93, 95% UI (1.18-3.15)), having daytime sleepiness (AOR=1.92, 95% UI (1.16-3.19)), and self-reported depressive symptoms (AOR=2.40, 95% UI (1.45-3.99)) were significantly associated with self-reported RBD. Conclusion. The current study revealed a high prevalence of self-reported RBD. This remarkable problem suggested a need to design strategies to prevent RBD symptoms among university students through targeting screening of depression, daytime sleepiness, and adjusting bedtime routines such as physical exercise and internet use immediately before going to bed.

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“…At least one biomarker, suggestive of ongoing neurodegeneration, however, was detected in 74% of the study population: mild cognitive impairment, hyposmia, substantia nigra hyperechogenicity or decreased color vision. Additional biomarkers of prodromal PD (abnormal heart rate variability and decreased striatal 123-I-ioflupane uptake) have also been identified in isolated RSWA patients [92,103]. Again, in isolated RSWA subjects RSWA severity correlated negatively with striatal 123-I-Ioflupan SPECT uptake [92].…”

Section: Isolated Rswa: a Prodromal Synucleinopathy Biomarker?mentioning

confidence: 94%

REM sleep without atonia and the relation with Lewy body disease

Dijkstra

Bossche

Bruyn

et al. 2019

Parkinsonism & Related Disorders

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REM sleep without atonia (RSWA) is the polysomnographic finding of persistent muscle tone during REM sleep, resulting in paroxysmal phasic or tonic EMG activity. RSWA is essential for the diagnosis of REM sleep behavior disorder (RBD), but can also occur without dream-enacting behavior. Loss of atonia during REM sleep is considered as a biomarker for synucleinopathies. We will give an overview of the pathophysiology of RSWA and will highlight the diagnostic methods for RSWA. We will describe the different etiologies of RSWA and finally we will focus on the role of RSWA as biomarker for Lewy body disease. RSWA severity in isolated RBD patients is a potential predictor for early conversion to Parkinson's disease (PD) or dementia with Lewy bodies. In PD patients, RSWA severity is associated with more severe motor symptoms and disease progression. Future studies are needed to delineate the importance of isolated RSWA as prodromal marker of Lewy body disease.

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Autonomic dysfunction in isolated rapid eye movement sleep without atonia

Cited by 22 publications

References 44 publications

Association of heart rate variability with REM sleep without atonia in idiopathic REM sleep behavior disorder

Association of heart rate variability with REM sleep without atonia in idiopathic REM sleep behavior disorder

Self-Reported Rapid Eye Movement Sleep Behavior Disturbance and Its Associated Factors among Medicine and Health Science Students at the University of Gondar

REM sleep without atonia and the relation with Lewy body disease

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