Autonomic dysfunction in Parkinson's disease: a comprehensive symptom survey

Siddiqui, Mariah; Rast, Shirley A.; Lynn, Michael; Auchus, Alexander P.; Pfeiffer, Ronald F.

doi:10.1016/s1353-8020(01)00052-9

Cited by 179 publications

(105 citation statements)

References 35 publications

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“…Siddiqui et al confirmed that autonomic dysfunction occurs in PD patients at a greater frequency and with a greater severity than in comparably aged controls [59]. It appears that gastrointestinal dysfunction might be a direct consequence of enteric neuron pathology and neurotransmitter impairment [8,9,59] or an indirect consequence of the pathology of the substantia nigra and striatum [60,61]. Several observations reported to date support the well-known Braak hypothesis [10,[62][63][64].…”

Section: Discussionmentioning

confidence: 91%

“…Thus, reduced colonic transit is likely to reflect the involvement of myenteric neurons in PD [9,50]. Siddiqui et al confirmed that autonomic dysfunction occurs in PD patients at a greater frequency and with a greater severity than in comparably aged controls [59]. It appears that gastrointestinal dysfunction might be a direct consequence of enteric neuron pathology and neurotransmitter impairment [8,9,59] or an indirect consequence of the pathology of the substantia nigra and striatum [60,61].…”

Section: Discussionmentioning

confidence: 99%

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Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol

Kurnik

Gil

Gajda

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Impairment of the enteric nervous system has been suggested to occur within the pathogenesis of neurodegenerative diseases. Thus, in the current study, we consider salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, SAL) as a substance that can potentially induce myenteric neurodegeneration. Material and methods. Male Wistar rats were subjected to continuous intraperitoneal dosing of salsolinol (200 mg/kg in total) with osmotic mini-pumps for either two or four weeks. An equivalent group of rats served as the control. Jejunal myenteric neurons were subjected to immunofluorescence staining to detect neuron specific protein -protein gene product (pan-neuronal marker, PGP 9.5), nitric oxide synthase (NOS), choline acetyltransferase (ChAT), Bax-protein and alpha-synuclein. In search of any functional impairment within the gastrointestinal tract, gut motility was assessed by determining the residual solid food contents in the stomach and the small and large intestine transit. Results. The myenteric neuron count, the mean size of the neuron body, the area of ganglia and the diameter of nerve strands were decreased in both of the salsolinol-treated groups compared with the controls. The number of NOS-positive cells was lower in the salsolinol-treated groups, while the number of ChAT-positive cells remained unchanged in comparison with the controls. Neurons expressing the pro-apoptotic Bax protein and alpha-synuclein deposits were observed among the myenteric neurons of the salsolinol-treated rats. Conclusions. Salsolinol evokes enteric neuronal cell death via initiation of apoptosis and leads to the formation of pathological aggregates of alpha-synuclein. Impairment of myenteric neurons, mainly the inhibitory motor neurons, might be responsible for the abnormal intestinal transit. Thus, salsolinol might be regarded as a suitable compound for inducing experimental enteric neurodegeneration in rats.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol

Kurnik

Gil

Gajda

et al. 2015

Folia Histochem Cytobiol.

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“…Although some studies have reported the use of a questionnaire to assess autonomic dysfunction, these questionnaires were never thoroughly validated. 23 Selection of SCOPA-AUT items was based on patient response criteria for frequency and burden and clinical relevancy as judged by specialists. The response rates of the two postal surveys were high, which may indicate the importance of these aspects to patients.…”

Section: Discussionmentioning

confidence: 99%

Assessment of autonomic dysfunction in Parkinson's disease: The SCOPA‐AUT

Visser¹,

Marinus²,

Stiggelbout³

et al. 2004

Movement Disorders

645

481

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We developed a questionnaire to assess autonomic symptoms in patients with Parkinson's disease (PD) and evaluated its reliability and validity. Based on the results of a postal survey in 46 PD patients, 21 multiple system atrophy patients, and 8 movement disorders specialists, items were included according to their frequency, burden, and clinical relevance. The questionnaire was evaluated in 140 PD patients and 100 controls, and test-retest reliability was established in a sample of 55 PD patients. The SCOPA-AUT consists of 25 items assessing the following regions: gastrointestinal (7), urinary (6), cardiovascular (3), thermoregulatory (4), pupillomotor (1), and sexual (2 items for men and 2 items for women) dysfunction. Test-retest reliability was good. Autonomic problems increased significantly with increasing disease severity for all autonomic regions, except sexual dysfunction. We conclude that SCOPA-AUT is a reliable and valid questionnaire that evaluates autonomic dysfunction in PD.

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“…However, cardivascular domain was only affected by duration of disease. Nevertheless, it has not be forgatten that a few studies reported in contrast to this but it may be due to use different questionnaire [13].…”

Section: Discussionmentioning

confidence: 94%

Autonomic symptoms in idiopathic parkinson’s disease

Arı

Candan²,

Işık³

et al. 2014

Cumhuriyet Med J

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Aim. Autonomic symptoms (AS) are one of the major causes affecting quality of life in Parkinson's disease (PD) patients and contribute to the disease burden. Our aim is to investigate the occurence of AS and to evaluate the relation between AS and the demographic and clinical features of PD patients. Method. In this study 66 idiopathic PD patients (47 men) were evaluated for the presence of AS during the last month with the SCOPA-AUT (Scales for Outcomes in Parkinson's Disease; SCOPA) questionnaire, which consists of 23 items in six domains: gastrointestinal (7), urinary (6), cardiovascular (3), thermoregulatory (4), pupillomotor (1), and sexual (2). The maximum score is 69, with a score range per item from 0 (never experiencing the symptom) to 3 (often experiencing the symptom). Associations between AS and duration of disease, age onset of disease, treatment and Hoehn &Yahr stage scores were also studied. Results. The mean (SD) age was 67.1 (9.5), disease duration 5.1 (3.9), age onset of disease 59 (10.9) years and Hoehn &Yahr median stage 1.9 (0.75, range I-IV). The presence of AS in all patients was observed. Mean SCOPA-AUT score was 15.6 (4-32). Total SCOPA-AUT scores were found significantly associated with duration of disease and Hoehn&Yahr stages (p<0.05), in contrast to age and gender. The most leading AS were in the gastorintestinal domain which was associated with the disease severity and duration also (p<0.05). Conclusion. AS were present in all patients even at the disease onset and early stages and increased with the disease severity and duration. For a better quality of life of the patient, it' s important to evaluate the presence of AS and initiate the appropriate treatment. Hastalar, OS'ları kapsamlı olarak tarayan 23 adet sorunun 6 ana alanda sorgulandığı bir anket (SKOPA-AUT Questionary) ile değerlendirildi. Bu anket ile gastrointestinal fonksiyonlar (7 soru), Üriner fonnksiyonlar (6 soru), kardiovasküler (3 soru), termoregulatuar (4 soru), pupillomotor (1 soru) ve seksüel fonksiyonlar (2 soru erkek, 2 soru kadın için) sorgulandı. Semptomların son 1 ay içindeki varlığı göz önünde bulunduruldu. Toplam skor 69 olup her soru 0 dan (hiç semptom yok) 3'e (sıklıkla semtom var) kadar skorlandı. Sempomlar ile hastaların yaşı, cinsiyeti, hastalık başlangıç yaşı, hastalık süresi ve Hoenh&Yahr (H&Y) evresi ile arasındaki ilişki incelendi. Bulgular. Hastaların ortalama yaşı 67,1 (9,5), süresi 5,1 (3,9), hastalık başlangıç yaşı 59 (10,9) yıl ve ortalama Hoehn &Yahr evresi 1,9 (0,75; I-IV) idi. Total SKOPA-AUT skoru 15,9 idi. Total skor ile yaş ve cinsiyet arasında bir ilişki olmayıp (p>0,05), hastalık süresi ve evresi arasında anlamlı bir ilişki bulundu (p<0,05). OS'ların en fazla gözlendiği alan gastrointestinal sistem olup hastalık süresi ve şiddeti ile de ilişkili olduğu saptandı. Sonuç. PH'nın erken evrelerinde ve hatta hastalığın başlangıç dönemlerinde dahi OS'lar görülebilmekte ve hastalık şiddeti ve süresi ile de artış göstermektedir. Parkinson hastalarında OS'lara yönelik ileri tetkik ve ted...

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Autonomic dysfunction in Parkinson's disease: a comprehensive symptom survey

Cited by 179 publications

References 35 publications

Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol

Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol

Assessment of autonomic dysfunction in Parkinson's disease: The SCOPA‐AUT

Autonomic symptoms in idiopathic parkinson’s disease

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