2020
DOI: 10.1038/s41598-020-68131-x
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Autonomic function in amnestic and non-amnestic mild cognitive impairment: spectral heart rate variability analysis provides evidence for a brain–heart axis

Abstract: Mild cognitive impairment (Mci) is a heterogeneous syndrome with two main clinical subtypes, amnestic (aMci) and non-amnestic (naMci). the analysis of heart rate variability (HRV) is a tool to assess autonomic function. cognitive and autonomic processes are linked via the central autonomic network. Autonomic dysfunction entails several adverse outcomes. However, very few studies have investigated autonomic function in Mci and none have considered Mci subtypes or the relationship of HRV indices with different c… Show more

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Cited by 38 publications
(48 citation statements)
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References 139 publications
(227 reference statements)
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“…It is generally accepted that cognitive score cut‐offs for MCI are 1.0 to 1.5 standard deviations below the mean of the normative group 61 (corresponding to the 7th and 16th percentiles, respectively, of the normative score distribution). We selected the 10th percentile threshold, in accordance with our previous work (e.g 62 63–65 …”
Section: Methodsmentioning
confidence: 99%
“…It is generally accepted that cognitive score cut‐offs for MCI are 1.0 to 1.5 standard deviations below the mean of the normative group 61 (corresponding to the 7th and 16th percentiles, respectively, of the normative score distribution). We selected the 10th percentile threshold, in accordance with our previous work (e.g 62 63–65 …”
Section: Methodsmentioning
confidence: 99%
“…The transmitral flow in diastolic refilling was impaired in patients with dementia who were not treated with acetylcholine esterase inhibitors. Thus, sympathetic hyperactivity might contribute to cognitive impairment (Vistisen et al, 2014;Nicolini et al, 2020). The percentage of patients with diabetes mellitus was higher in…”
Section: The Role Of Nfl For Risk Assessment For Cognitive Impairmentmentioning
confidence: 99%
“…In line with pioneer observations of Claude-Bernard, Thayer and Lane have proposed that HRV could also be an index of the level to which the brain generates an adaptive peripheral body’s response to environmental changes [ 129 ]. A very recent study confirms that HRV analysis provides insight into a “brain-heart-axis” in old patients with mild cognitive impairments, suggesting that this autonomic assessment could help to identify subjects at higher risk of adverse health outcomes, especially among AD patients [ 130 ].…”
Section: Ambulatory Monitoring Of Auricular Vagal Tone Through Heart mentioning
confidence: 99%