Autonomic nerve function in adults with cyclic vomiting syndrome: a prospective study

Venkatesan, Thangam; Prieto, Thomas; Barboi, Alexandru; Li, B.; Schroeder, Abigail; Hogan, Walter J.; Ananthakrishnan, Ashwin N.; Jaradeh, Safwan

doi:10.1111/j.1365-2982.2010.01577.x

Cited by 82 publications

(65 citation statements)

References 22 publications

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“…A well-recognised hypothesis is that CVS is caused by psychological or infectious triggers, which lead to alterations in autonomic brain-gut pathways 7 8. The association between CVS and migraine headache also supports an underlying stress-sensitive disorder,9 with a common pathophysiological mechanism.…”

Section: Introductionmentioning

confidence: 99%

Cyclic vomiting syndrome: a case series and review of the literature

Shearer

Luthra

Ford

2016

Frontline Gastroenterol

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Section: Introductionmentioning

confidence: 99%

Cyclic vomiting syndrome: a case series and review of the literature

Shearer

Luthra

Ford

2016

Frontline Gastroenterol

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“…Abnormal vagal modulation of the heart has been described in patients [5][6][7] with tachygastria noted on electrogastrography [8,9]. CVS is associated with migraines.…”

Section: Introductionmentioning

confidence: 99%

The management of cyclic vomiting syndrome

L¹,

Abbott²,

Mahlangu³

et al. 2012

European Journal of Gastroenterology & Hepatology

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Cyclic vomiting syndrome (CVS) is a rare abnormality of the neuroendocrine system that affects 2% of children. It is a frequently missed diagnosis in the emergency department and may require a number of emergency department visits before the diagnosis is made. The objectives of this review are to identify the clinical features that suggest a diagnosis of CVS and to review the literature on its management. The MEDLINE and EMBASE databases were searched from January 1948 to October 2011 using the keywords 'Cyclic' or 'Vomiting'. Papers were excluded if they did not follow the consensus guidelines or if they were case reports. This review analysed 1093 cases of cyclic vomiting in 25 papers that fulfilled the inclusion criteria. All except one paper were retrospective studies. The size of these cohort studies ranged from three to 181 patients, with a mean patient size of 29. This review found that over 40% of patients have headaches/migraines, with associated anxiety and depression in ≈ 30% of cases. There is a family history of headaches/migraines in 38.9%, and this association was much stronger in the adult CVS cohort compared with the paediatric cohort. Compared with paediatric CVS, adults have a longer duration of attacks and they occur more frequently (5.9 vs. 3.4 days, 14.4 vs. 9.6 episodes/year). Limited data are available on the treatment of the acute phase of CVS, but in adults, sumatriptan has been shown to be effective. For prophylactic treatment, tricyclics are effective in both adult and paediatric CVS, with a clinical response in 75.5 and 67.6% of patients, respectively, in nonplacebo-controlled cohort studies. Furthermore, propranolol has been shown to be useful in children. CVS is an intractable illness with a major impact on the patient's quality of life. There is a long duration between the onset of symptoms and the diagnosis of the condition. There is a high association with headaches/migraines and anxiety/depression. The symptoms are more severe in adult-onset CVS. Tricyclic antidepressants have good efficacy in reducing the frequency/duration or the intensity of attacks. There is limited evidence on the acute management of CVS.

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“…The cause is likely a result of disorders of the central neural pathways and neuroendocrine mediators involved in the brain-gut pathways of nausea and vomiting [3]. There is also some evidence to suggest underlying abnormalities in the mitochondria [5][6][7] and the autonomic nervous system [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Cyclic vomiting syndrome in 28 patients

Lee

Abbott

Moodie

et al. 2012

European Journal of Gastroenterology & Hepatology

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CVS is a debilitating illness with frequent attacks of prolonged duration. There is a high association with anxiety/depression as well as headaches. Antimigraine medication, β-blockers and antiepileptic treatment may be successful at attenuating attacks; however, in this long-term study, the prognosis of patients not treated with these medications was also good. Overall, 61.9% of patients showed a gradual improvement in symptoms and 23.8% had complete resolution after a mean of 7 years.

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Autonomic nerve function in adults with cyclic vomiting syndrome: a prospective study

Cited by 82 publications

References 22 publications

Cyclic vomiting syndrome: a case series and review of the literature

Cyclic vomiting syndrome: a case series and review of the literature

The management of cyclic vomiting syndrome

Cyclic vomiting syndrome in 28 patients

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