Autonomics and cognition

Goldstein, Martin; Silverman, Michael E.

doi:10.1007/s10286-006-0339-2

Cited by 5 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the physiological processes mediating the relationship between blood pressure and brain function, it must be taken into account that blood pressure can influence cortical activation processes via afferent projections [47, 55–57]. The brain continuously receives information about the state of the cardiovascular system by means of viscero-afferent fibers [23].…”

Section: Neuroelectrophysiological Correlates Of Hypotension-related mentioning

confidence: 99%

Reduced brain perfusion and cognitive performance due to constitutional hypotension

2006

View full text Add to dashboard Cite

Section: Neuroelectrophysiological Correlates Of Hypotension-related mentioning

confidence: 99%

Reduced brain perfusion and cognitive performance due to constitutional hypotension

2006

View full text Add to dashboard Cite

“…A relationship between autonomic failure, including OH, and neuropsychological dysfunction has been recently reported [16,19] This is an important issue, as there is evidence suggesting a bi-directional interactions between cognitive and autonomic process [15] and neurovascular instability, including OH, has been reported in neurodegenerative dementias [4]. It has been proposed that brain hypoperfusion in the setting of hypotension may result in subcortical ischemic vascular dementia [24].…”

mentioning

confidence: 97%

Autonomic and Cognitive dysfunction in Parkinson’s disease

et al. 2007

View full text Add to dashboard Cite

The results of this limited study indicate that despite the higher incidence of cardiovascular symptoms in PD patients with dementia than in those without dementia, there is no consistent association between OH or PPH and cognitive deficits in PD. The lack of correlation between OH, gastrointestinal and urinary symptoms with cognitive impairment suggests that cognitive and autonomic involvement progresses independently from each other and variably among PD patients.

show abstract

“…Craig 2002;Goldstein & Silverman 2006;Miyashita & Williams 2006), as yet the neural substrates that allow this interaction are not established. "Bottom-up" viscerosensory (systemic/interoceptive) challenges with e.g.…”

Section: Introductionmentioning

confidence: 99%

Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior

Goehler¹,

Park²,

Opitz³

et al. 2008

Brain, Behavior, and Immunity

249

124

View full text Add to dashboard Cite

The presence of certain bacteria in the gastrointestinal tract influences behavior and brain function. For example, challenge with live Campylobacter jejuni (C. jejuni), a common food-born pathogen, reduces exploration of open arms of the plus maze, consistent with anxiety-like behavior, and activates brain regions associated with autonomic function, likely via a vagal pathway. As yet, however, little is known regarding the interface of immune sensory signals with brain substrates that mediate changes in behavioral states. To address this issue, we challenged mice with either C. jejuni or saline, and 7-8h later assessed anxiety-like behavior using the open holeboard, and used immunohistochemical detection of the protein c-Fos as an activation marker in the brain. C. jejuni treatment was associated with increased avoidance of the center regions of the holeboard, compared to saline-treated controls. Exposure to the holeboard induced activation in multiple brain regions previously implicated in anxiety-like behavior, including the lateral septum (LS), paraventricular (PVN) and dorsomedial hypothalamic nuclei (DMH), basolateral and central nuclei of the amygdala (BLA, CEA), bed nucleus of the stria terminalis (BST) and periaquiductal grey (PAG), compared to homecage controls. In C. jejuni-treated animals c-Fos induction also occurred in autonomic regions, as previously reported. The PVN, BLA, parts of the BST, medial prefrontal (mPFC) and anterior cingulate responded to both C. jejuni treatment and the holeboard, suggesting a role for these regions in the enhanced anxiety-like behavior observed. In saline-treated animals, anxiety-like behavior was predicted by activation in the CEA and BLA, whereas in C. jejuni-treated animals, c-Fos expression in the BST predicted the degree of anxiety-like behavior. These findings implicate the PVN, amygdala and BST as interfaces between gastrointestinal pathogenic challenge and brain regions that mediate behavioral responses to stress, and reinforce these nuclei as anatomical substrates by which viscerosensory stimuli can influence behavior.

show abstract

Autonomics and cognition

Cited by 5 publications

References 31 publications

Reduced brain perfusion and cognitive performance due to constitutional hypotension

Reduced brain perfusion and cognitive performance due to constitutional hypotension

Autonomic and Cognitive dysfunction in Parkinson’s disease

Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior

Contact Info

Product

Resources

About