Autophage as a control measure for Salmonella in laying hens

Characteristics of a Series of Three Bacteriophages Infecting Salmonella enterica Strains

“…In fact, many papers have been published recently which described bacteriophages that might be used in phage therapy against Salmonella . They include reports on characterization of previously unknown bacteriophages having the potential for use in phage therapy [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ], experimental studies with bacteriophages applied to poultry [ 21 , 22 , 23 , 24 , 25 , 26 ], and the use of bacteriophages in experimental phage therapy in mouse [ 27 , 28 , 29 , 30 ] or pig [ 31 ] models. Although promising results were obtained in these studies, and economic analyses have been performed to assess costs and benefits of the use of phage therapy for the control of Salmonella in poultry [ 9 , 32 ], it is evident that the host range of the vast majority of Salmonella phages is restricted to specific strains or serovars.…”

Fast and Slow-Growing Management Systems: Characterisation of Broiler Caecal Microbiota Development throughout the Growing Period

“…Moreover, due to the emergence of antimicrobial-resistant bacteria, society is pressing for a reduction in antibiotic administration by finding effective alternatives to control infectious diseases at farm level [ 12 , 13 , 14 , 15 ]. Some of these alternatives are feed additives (prebiotics, probiotics, symbiotics, organic acids, enzymes, phytogenics and metals), alternative medical treatments (antibacterial vaccines, immunomodulatory agents, antimicrobial peptides and bacteriophages) and, finally, different, less intensified broiler management systems [ 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Although the beneficial effects of many of these alternatives have been demonstrated in vitro, the general consensus is that the effect of these products depends on the farm, farmer management and animal characteristics, such as the breed selected [ 11 , 14 , 23 ].…”

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“…Además, al problema de la supervivencia de Salmonella y Campylobacter en el sector avícola, se suma una importante amenaza en salud pública, como es la adquisición de resistencias a los antibióticos, que ha llevado a importantes restricciones al uso de antibióticos en la producción avícola y a la búsqueda de nuevas alternativas a su empleo para el control de la bacteria a nivel de campo. Ante esta situación, nuestro grupo lleva 5 años estudiando la aplicación de bacteriófagos a nivel de campo, dentro de un proyecto CAMPYSALMO: del laboratorio a las aulas Europeo (H2020) y obteniendo resultados prometedores como herramienta alternativa al uso de antibióticos (Sevilla-Navarro et al, 2018;2020b). De la misma manera, hemos estudiado y analizado el impacto del bienestar animal sobre la microbiota intestinal del ave, así como sobre la adquisición y pérdida de multiresistencias a antibióticos, para lo cual se han utilizado herramientas de secuenciación genómica de última generación (Montoro-Dasi et al, 2020).…”