Autophagy mediated TiAl 6 V 4 particle-induced peri-implant osteolysis by promoting expression of TNF-α

Liu, Naicheng; Meng, Jia; Wang, Zhenheng; Zhou, Gang; Shi, Tongguo; Zhao, Jianning

doi:10.1016/j.bbrc.2016.03.065

Cited by 35 publications

(28 citation statements)

References 25 publications

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“…However, this material has been shown to be biomechanically incompatible owing to its higher elastic modulus compared with that of bone. Further, Ti-Al-V has been associated with the release of V into the blood and urine [7], initiation of the inflammatory cascade leading to osteolysis [8,9], neurotoxic effects, negative cell viability response, and, consequently, an undesirable outcome for implant biocompatibility with ion release [10][11][12]. In addition, Al has been shown to be present in brain tissue of patients with Alzheimer's disease [13].…”

Section: Introductionmentioning

confidence: 99%

Development of binary and ternary titanium alloys for dental implants

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Development of binary and ternary titanium alloys for dental implants

et al. 2017

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“…It is found that the autophagy is involved in promoting the apoptosis of osteoblasts which are caused by wear particles and inhibits the plasma reticulum stress. Moreover, autophagy can reduce in ammatory factor secretion and osteoclast production and alleviate the effects of wear particles on osteoblasts [36][37][38]. 4) Destroy cell structure:…”

Section: Discussionmentioning

confidence: 99%

Alpha Lipoic Acid Antagonizes Cytotoxicity of Cobalt Nanoparticles by Inhibiting Ferroptosis-like Cell Death

Liu

Zhu

et al. 2020

Preprint

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As a main element in the hard metal industry, cobalt is one of the major components of human metal implants. Cobalt-containing implants, especially joint prostheses used for artificial joint replacement, can be corroded due to the complex physiological environment in vivo, producing a large number of nanoscale cobalt particles (Cobalt Nanoparticles, CoNPs). These CoNPs can be first accumulated around the implant to cause adverse local reactions and then enter into the blood vessels followed by reaching to the liver, heart, brain, kidney, and other organs through systematic circulation, which leads to multi-system toxicity symptoms. To ensure the long-term existence of cobalt-containing implants in the body, it is urgently required to find out a safe and effective detoxification drug. Herein, we have demonstrated that CoNPs could induce the ferroptosis-like cell death through the enhancement of intracellular reactive oxygen species (ROS) level, cytoplasmic Fe2+ level, lipid peroxidation and consumption of reduced glutathione (GSH) as well as inhibition of glutathione peroxidase 4 (GPX4) activity. Importantly, α-lipoic acid (ALA), a natural antioxidant with the capability to scavenge free radicals and chelate toxic metals, was found to efficiently alleviate the adverse effects of CoNPs. The present study illustrates a new mechanism of CoNPs mediated by ferroptosis-like cytotoxicity and discloses an effective method for the detoxification of CoNPs by employing the natural antioxidant of ALA, providing a basis for further in vivo detoxification study.

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“…Moreover, autophagy can reduce in ammatory factor secretion and osteoclast production and alleviate the effects of wear particles on osteoblasts [36][37][38]. 4) Destroy cell structure: CoNPs and cobalt ions could directly bind to proteins with multiple functions in the cells including redox system enzymes, metabolism, molecular transport, cell signaling, and organelles [39].…”

Section: Discussionmentioning

confidence: 99%

Alpha lipoic acid antagonizes cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis-like cell death

Liu

Zhu

et al. 2020

Preprint

View full text Add to dashboard Cite

As a main element in the hard metal industry, cobalt is one of the major components of human metal implants. Cobalt-containing implants, especially joint prostheses used for artificial joint replacement, can be corroded due to the complex physiological environment in vivo , producing a large number of nanoscale cobalt particles (Cobalt Nanoparticles, CoNPs). These CoNPs can be first accumulated around the implant to cause adverse local reactions and then enter into the blood vessels followed by reaching to the liver, heart, brain, kidney, and other organs through systematic circulation, which leads to multi-system toxicity symptoms. To ensure the long-term existence of cobalt-containing implants in the body, it is urgently required to find out a safe and effective detoxification drug. Herein, we have demonstrated that CoNPs could induce the ferroptosis-like cell death through the enhancement of intracellular reactive oxygen species (ROS) level, cytoplasmic Fe 2+ level, lipid peroxidation and consumption of reduced glutathione (GSH) as well as inhibition of glutathione peroxidase 4 (GPX4) activity. Importantly, α-lipoic acid (ALA), a natural antioxidant with the capability to scavenge free radicals and chelate toxic metals, was found to efficiently alleviate the adverse effects of CoNPs. The present study illustrates a new mechanism of CoNPs mediated by ferroptosis-like cytotoxicity and discloses an effective method for the detoxification of CoNPs by employing the natural antioxidant of ALA, providing a basis for further in vivo detoxification study.

show abstract

Autophagy mediated TiAl 6 V 4 particle-induced peri-implant osteolysis by promoting expression of TNF-α

Cited by 35 publications

References 25 publications

Development of binary and ternary titanium alloys for dental implants

Development of binary and ternary titanium alloys for dental implants

Alpha Lipoic Acid Antagonizes Cytotoxicity of Cobalt Nanoparticles by Inhibiting Ferroptosis-like Cell Death

Alpha lipoic acid antagonizes cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis-like cell death

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