Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Lü, Ling; Liang, Qiaoyan; Zhang, Xinyi; Xu, Yumeng; Meng, Dehua; Liang, Zhaofeng

doi:10.2147/cmar.s364761

Cited by 3 publications

(6 citation statements)

References 71 publications

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“…A series of studies using apoptosis have been proved to be effective in the prevention and treatment of many diseases including cancer ( Pistritto et al, 2016 ; Xu et al, 2019 ; Berthenet et al, 2020 ). Cell autophagy is a highly conserved self-defense mechanism ( Lu et al, 2022 ). Autophagy plays a key role in the occurrence, development and prognosis of GC ( Cao et al, 2019 ; Wu et al, 2021 ; Lu et al, 2022 ).…”

Section: Effects Of Phytochemicals On the Occurrence And Development ...mentioning

confidence: 99%

“…Cell autophagy is a highly conserved self-defense mechanism ( Lu et al, 2022 ). Autophagy plays a key role in the occurrence, development and prognosis of GC ( Cao et al, 2019 ; Wu et al, 2021 ; Lu et al, 2022 ). Induction of cell apoptosis and autophagy has been found maybe a pivotal mechanism of the inhibition of the initiation and the development of gastric cancer.…”

Section: Effects Of Phytochemicals On the Occurrence And Development ...mentioning

confidence: 99%

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Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism

Liang

Zhang

et al. 2023

Front. Pharmacol.

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Gastric cancer (GC) is the fourth most common malignant cancer and is a life-threatening disease worldwide. Phytochemicals have been shown to be a rational, safe, non-toxic, and very promising approach to the prevention and treatment of cancer. It has been found that phytochemicals have protective effects against GC through inhibiting cell proliferation, inducing apoptosis and autophagy, suppressing cell invasion and migration, anti-angiogenesis, inhibit Helicobacter pylori infection, regulating the microenvironment. In recent years, the role of phytochemicals in the occurrence, development, drug resistance and prognosis of GC has attracted more and more attention. In order to better understand the relationship between phytochemicals and gastric cancer, we briefly summarize the roles and functions of phytochemicals in GC tumorigenesis, development and prognosis. This review will probably help guide the public to prevent the occurrence and development of GC through phytochemicals, and develop functional foods or drugs for the prevention and treatment of gastric cancer.

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Section: Effects Of Phytochemicals On the Occurrence And Development ...mentioning

confidence: 99%

Section: Effects Of Phytochemicals On the Occurrence And Development ...mentioning

confidence: 99%

Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism

Liang

Zhang

et al. 2023

Front. Pharmacol.

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“…Autophagy is a conserved self-defense mechanism that responds to various cellular stresses [16][17][18]. Normal and moderate autophagy is particularly important for cell survival and maintaining homeostasis.…”

Section: Introductionmentioning

confidence: 99%

“…Dysregulation of autophagy involves the occurrence and development of a variety of diseases, including gastric cancer. Increasing pieces of evidence show that autophagy plays a critical role in the occurrence and development of gastric cancer [17,19,20]. Studies demonstrated that autophagy plays a regulatory role in the occurrence and development of cancer by regulating EMT and abnormal cell proliferation [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…Autophagy is regulated by different signaling pathways (PI3K/AKT, P53, MAPK, PTEN, AMPK, etc.) and ncRNAs (miRNA, lncRNA, circRNAs) [16][17][18]24,25]. Therefore, investigating the mechanism of MNNG-mediated gastric autophagy, EMT, and abnormal cell proliferation may provide new insights for the early treatment and intervention of gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

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Hesperidin Reversed Long-Term N-methyl-N-nitro-N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats

Liang

Song

et al. 2022

Nutrients

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Gastric cancer is a common malignant tumor worldwide. N-methyl-N-nitro-N-nitroguanidine (MNNG) is one of the most important inducing factors of gastric cancer. Autophagy can affect the occurrence and development of gastric cancer, but the mechanism is not clear. Chemoprevention has been shown to be a rational and very promising approach to the prevention of gastric cancer. Hesperidin is a citrus flavone, an abundant polyphenol in citrus fruits and traditional Chinese medicine. It has an excellent phytochemistry that plays an intervention role in gastric cancer. However, it is unclear whether long-term exposure to MNNG will affect the occurrence of gastric cancer by regulating autophagy and whether hesperidin can play an intervention role in this process. In the present study, we demonstrated that long-term MNNG exposure inhibits autophagy in stomach tissues of rats, promotes the epithelial–mesenchymal transition (EMT) process and cell proliferation and suppresses the activity of the PI3K/AKT pathway. We further found that after rapamycin-activated autophagy, long-term MNNG exposure promoted cell proliferation and EMT were inhibited. In addition, hesperidin promotes autophagy and the activity of the PI3K/AKT pathway, as well as the suppression of proliferation and EMT in the stomach tissues of rats. Our findings indicate that hesperidin reverses MNNG-induced gastric cancer by activating autophagy and the PI3K/AKT pathway, which may provide a new basis for the early prevention and treatment of MNNG-induced gastric cancer.

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The effect of phytochemicals in N-methyl-N-nitro-N-nitroguanidine promoting the occurrence and development of gastric cancer

Chen

Zhang

et al. 2023

Front. Pharmacol.

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Gastric cancer is a common malignant tumor of the digestive tract, with a low early diagnosis rate. N-methyl-N-nitro-N-nitroguanidine (MNNG) is one of the main risk factors for gastric cancer. Phytochemicals are healthy active substances derived from vegetables, fruits, nuts, tea, herbal medicines and other plants. Taking phytochemicals is a very promising strategy for the prevention and treatment of gastric cancer. Many studies have proved that phytochemicals have protective effects on MNNG induced gastric cancer via inhibiting cell proliferation, enhancing immunity, suppressing cell invasion and migration, inducing apoptosis and autophagy, blocking angiogenesis, inhibiting Helicobacter pylori infection as well as regulating metabolism and microbiota. The intervention and therapeutic effects of phytochemicals in MNNG induced gastric cancer have attracted more and more attention. In order to better study and explore the role, advantages and challenges of phytochemicals in MNNG induced gastric cancer, we summarized the intervention and therapeutic effects of phytochemicals in MNNG induced gastric cancer. This review may help to further promote the research and clinical application of phytochemicals in MNNG induced gastric cancer, and provide some new insights.

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Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Cited by 3 publications

References 71 publications

Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism

Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism

Hesperidin Reversed Long-Term N-methyl-N-nitro-N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats

The effect of phytochemicals in N-methyl-N-nitro-N-nitroguanidine promoting the occurrence and development of gastric cancer

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