2015
DOI: 10.1002/jor.23007
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Auxiliary proteins that facilitate formation of collagen‐rich deposits in the posterior knee capsule in a rabbit‐based joint contracture model

Abstract: Post-traumatic joint contracture is a debilitating consequence of trauma or surgical procedures. It is associated with fibrosis that develops regardless of the nature of initial trauma and results from complex biological processes associated with inflammation and cell activation. These processes accelerate production of structural elements of the extracellular matrix, particularly collagen fibrils. Although the increased production of collagenous proteins has been demonstrated in tissues of contracted joints, … Show more

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Cited by 24 publications
(83 citation statements)
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References 59 publications
(147 reference statements)
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“…All animal studies were approved by the TJU Institutional Animal Care and Use Committee. The following attributes make rabbits a relevant model to study post‐traumatic joint contracture: (i) the critical α2Ct epitope recognized by the ACA in rabbits is identical with its human counterpart and (ii) the rabbit model employed here adequately represents clinical features associated with post‐traumatic joint contractures in human patients …”
Section: Methodsmentioning
confidence: 99%
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“…All animal studies were approved by the TJU Institutional Animal Care and Use Committee. The following attributes make rabbits a relevant model to study post‐traumatic joint contracture: (i) the critical α2Ct epitope recognized by the ACA in rabbits is identical with its human counterpart and (ii) the rabbit model employed here adequately represents clinical features associated with post‐traumatic joint contractures in human patients …”
Section: Methodsmentioning
confidence: 99%
“…We employed an established rabbit model of post‐traumatic joint contracture . In brief, knee injury is caused by intra‐articular fracture and mechanical disruption of the posterior capsule (PC).…”
Section: Methodsmentioning
confidence: 99%
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