Avaliação biomecânica e dimensional do fio de sutura à base de quitosana

Alves, Alane Pereira; Sá, Marcelo Jorge Cavalcanti de; Fook, Marcus Vinícius Lia; Felipe, G.C.; Henrique, Fernanda Vieira; Albuquerque, Erica Emerenciano; Medeiros, Lylian Karlla Gomes de; Alexandre, P.R.S.

doi:10.1590/1678-4162-9164

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…This maintains the position of the tissue during healing, and the wound edges close together. A good suture should still be pliable so as to facilitate handling [50,62,63].…”

Section: Resultsmentioning

confidence: 99%

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

Silva

Cruz

et al. 2019

Materials

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The aim of this study was to prepare chitosan (CS) filaments incorporated with N-acetyl-D-Glucosamine (GlcNAc), using the wet spinning method, in order to combine the GlcNAc pharmacological properties with the CS biological properties for use as absorbable suture materials. The filaments were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), uniaxial tensile testing, in vitro biodegradation, and through in vitro drug release and cytotoxicity studies. It was observed that the addition of GlcNAc did not alter the morphology of the filaments. The CS and CS/GlcNAc filaments presented diameters 145 µm and 148 µm, respectively, and the surfaces were homogeneous. Although the mechanical resistance of the chitosan filaments decreased with the incorporation of the GlcNAc drug, this property was greater than the mean values indicated in the U.S. Pharmacopeia (1.7 N) for suture number 6-0 (filament diameter of 100–149 μm). The biodegradation of the CS filaments was accelerated by the addition of GlcNAc. After 35 days, the CS/GlcNAc filaments degradability was at its total, and for the CS filaments it was acquired in 49 days. The in vitro kinetic of the release process was of the zero-order and Hopfenberg models, controlled by both diffusion and erosion process. The in vitro cytotoxicity data of the CS and CS/GlcNAc filaments toward L929 cells showed that these filaments are nontoxic to these cells. Thus, the GlcNAc-loaded CS filaments might be promising as absorbable suture materials. In addition, this medical device may be able to enhance healing processes, relieve pain, and minimize infection at the surgery site due the prolonged release of GlcNAc.

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“…This maintains the position of the tissue during healing, and the wound edges close together. A good suture should still be pliable so as to facilitate handling [50,62,63].…”

Section: Resultsmentioning

confidence: 99%

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

Silva

Cruz

et al. 2019

Materials

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“…Thus, research continued with the development of surgical biomaterials, such as chitosan‐based threads. The material has the advantages of monofilament production, smooth surface, and hydrolysis absorption 8–15 …”

Section: Introductionmentioning

confidence: 99%

“…The material has the advantages of monofilament production, smooth surface, and hydrolysis absorption. [8][9][10][11][12][13][14][15] Chitosan suture thread is also expected to replicate hemostatic, 16 antiadherent, 17 and angiogenic potentials, stimulate fibroplasia 18 and proliferation of granulation tissue, 19 and promote the chemotaxis of macrophages 20 and fibroblasts, 21 actions evidenced with other biomaterials based on this organic polymer. [16][17][18][19][20][21] However, this suture thread was submitted to animal experimentation and evaluation of its effects on tissue repair on only three occasions.…”

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confidence: 99%

Chitosan thread in the healing of the cecal wall of rabbits (Oryctolagus cuniculus) submitted to cecorrhaphy

Filho¹,

Moura

Queiroz

et al. 2023

J Biomed Mater Res

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The development and evaluation of synthesis materials are crucial to reducing the morbidity and magnitude of post‐enterorrhaphy surgical complications. Despite the possibility of production, chitosan thread has not yet been used in enterorrhaphy, and its effects on intestinal healing have not been evaluated. Therefore, this study aimed to evaluate the effects of chitosan thread on the intestinal wall repair of rabbits submitted to cecorrhaphy. For this, 42 rabbits were allocated into two groups with 21 animals. One group was submitted to cecorrhaphy with chitosan suture thread (CG) and the other with poliglecaprone suture thread (PG). The occurrence of postoperative complications, the intensity of edema, cellular response, formation of granulation tissue, as well as the deposition and maturation of collagen fibers, and the intensity of vascular endothelial growth factor (VEGF‐α) expression, were evaluated during the intestinal wall repair process. The evaluations occurred on the 5th, 15th, and 25th postoperative (PO) days. The animals did not develop peritonitis, but adherence was observed in six animals from CG and seven from PG, with no difference between groups. The polymorphonuclear infiltrate showed higher intensity and higher amount of type III collagen fibers in CG on the 15th PO day. In contrast, a lower amount of type I collagen fibers was observed in CG samples on the 25th PO day. Therefore, the chitosan thread used for cecorrhaphy in rabbits results in minimal postoperative complications, presents biocompatibility, and bioactively assists the tissue repair process of the cecal wall, inducing minimal tissue reaction, stimulating the deposition of type III collagen fibers in the proliferative phase, with sustained VEGF‐α expression, but with reduced deposition of type I fibers, indicating a delay in collagen maturation.

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