Avaliação do efeito antinociceptivo e da toxicidade aguda do extrato aquoso da Hyptis fruticosa Salmz. ex Benth

Abstract

RESUMO:Este trabalho descreve o efeito antinociceptivo e a toxicidade aguda do extrato aquoso das folhas da Hyptis fruticosa Salmz. ex Benth. (Lamiaceae). O extrato aquoso liofi lizado, administrado por via oral, reduziu as contorções abdominais induzidas por ácido acético (200, 400 e 500 mg/kg) e o tempo de reação dos animais na primeira fase do teste da formalina (100 mg/kg e 400 mg/kg). No teste da placa quente, o extrato aquoso aumentou o tempo de latência ao calor (100 e 200 mg/kg) tendo este efeito sido revertido pelo antagonista opióide naloxona (5 mg/kg; i.p.). No ensaio de toxicidade aguda, não foi detectada a morte de nenhum animal após tratamento com doses de até 5 g/kg (v.o.) do extrato. Em conclusão, os resultados obtidos indicam que o extrato aquoso da Hyptis fruticosa apresenta efeito antinociceptivo em camundongos e não apresenta toxicidade aguda nas doses testadas. Unitermos:Hyptis fruticosa, Lamiaceae, antinociceptivo, toxicidade aguda, extrato aquoso. ABSTRACT: "Evaluation of the analgesic effect and acute toxicity of the aqueous extract ofHyptis fruticosa (Salmz. ex Benth.)". The antinociceptive effect and the acute toxicity of Hyptis fruticosa leaves were evaluated through the administration of its aqueous extract in mice. The extract, administered orally (200, 400, and 500 mg/kg), reduced the nociceptive response in the writhing test as well as in the early phase of the formalin test (100 and 400 mg/kg) and it increased the latency time in the hot plate test (100 and 200 mg/kg). The antinociceptive effect was reversed by naloxone (5 mg/kg, i.p.). Moreover, no animal deaths were observed in doses up to 5 g/kg. In conclusion, the aqueous extract of Hyptis fruticosa showed no acute toxicity at the evaluated doses and revealed antinociceptive effect in mice. Such effects are possibly associated with the opioid system activation.

Substrate composition and indolebutyric acid on the propagation of Eplingiella fruticosa from cuttings

“…This aromatic plant has a high medicinal and therapeutic potential and is commonly used as a painkiller. The medicinal properties of its essential oil and other extracts have been tested in rats and show edanalgesic, antiinflammatory, antioxidant, and vasodilator effects (SILVA et al, 2006;SANTOS et al, 2007;ANDRADE et al, 2010;MOREIRA et al, 2010;FRANCO et al, 2011;LIMA et al, 2013). Nevertheless, there are no Silva et al record sons the cultivation of this species.…”

Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats

“…It is popularly used to treat pain. Besides, it has been shown antinociceptive effect in mice 2 . Two quinoids were isolated, from this plant, with antimicrobial and antineoplastic effect against Gram-positive microorganisms and mouse Erlich carcinoma studies, respectively 3 .…”

In vitro anti-staphylococcal activity of Hyptis martiusii Benth against methicillin-resistant Staphylococcus aureus: MRSA strains

“…Chemical compounds as fl avonoids (Isobe et al, 2006), triterpenes (Falcão et al, 2003), diterpenes (Ohsaki et al, 2005) and sesquiterpenes (Facey et al, 2005), with antimicrobial, insecticidal, analgesic, antiplasmodial activities and antidepressive effect (Okiemy-Andissa et al, 2004;Fragoso-Serrano et al, 2005;Chukwujekwu et al, 2005;Isobe et al, 2006;Silva et al, 2006;Bueno et al, 2006) were isolated on other plants from the genus Hyptis.…”