Avaliação Do Perfil Lipídico E Hepático De Ratos Wistar Alimentados Com Dieta Hipercalórica E Suplementados Com Bixina

Abstract

The hypercaloric diet is an important inducer of dyslipidemias and, in turn, causes damage to health, especially to the liver.This work was developed with the objective of testing bixin, a carotenoid present in the seeds of annatto (Bixa orellanaL.), verifying its side effects on lipid and hepatic metabolism in rats. Fifteen animals were randomly divided into control (C), hypercaloric (H) and hypercaloric groups with bixin (H+B) with five animals each, receiving feed ad libtumduring the period of 25 days.The diet with bixin promoted weight maintenance, decreased ALT levels, decreased triglyceride levels and increased HDL-c. Theliver histopathology showed a decrease in fat degeneration, inflammatory infiltrate and cell injury.