Avanafil Liposomes as Transdermal Drug Delivery for Erectile Dysfunction Treatment: Preparation, Characterization, and &lt;i&gt;In vitro, Ex vivo &lt;/i&gt;and &lt;i&gt;In vivo&lt;/i&gt; Studies

Hosny, Khaled M.; Aldawsari, Hibah M

doi:10.4314/tjpr.v14i4.1

Cited by 13 publications

(7 citation statements)

References 19 publications

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“…Avanafil (AV) is the second-generation phosphodiesterase-5 enzyme inhibitor (PDE-5), used as an effective medication for erectile dysfunction [ 1 , 2 ]. Erectile dysfunction is the inability of men to attain or maintain enough erection in completing the sexual activity [ 3 ] and as a public health issue; this can impact psychological condition, quality of life and the marital relationship of patients [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells

Kurakula

N.²,

Patel³

et al. 2021

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(1) Introduction: in recent decades, interdisciplinary research on the utilization of natural products as “active moiety carriers” was focused on due to their superior safety profile, biodegradability, biocompatibility and the ability for sustained or controlled release activity. The nano-based neuroprotective strategy is explored as an imperative treatment for diabetic neuropathy (DN). Avanafil (AV), that selectively inhibits the degradation of cGMP-specific phosphodiesterase, thereby increasing the levels of cGMP, makes a decisive mediator for cytoprotection. (2) Methods: AVnanocomplex formulations were prepared by a modified anti-solvent precipitation method and the method was optimized by Box–Behnken design. An optimized formulation was characterized and evaluated for various in vitro parameters; (3) results:based on the desirability approach, the formulation containing 2.176 g of chitosan, 7.984 g of zein and 90% v/v ethanol concentration can fulfill the prerequisites of optimum formulation (OB-AV-NC).OB-AV-NC was characterized and evaluated for various parameters. The neuroprotective mechanism of AV was evaluated by pretreatment of PC12 cells with plain AV, avanafil nanocomplex (NC) without antioxidants (AV-NC) and with antioxidants (α-Lipoic acid LP; Ellagic Acid EA), AV-LP-EA-Nanocomplex has also shown considerable attenuation in intracellular reactive oxygen species (ROS) and lipid peroxidation with a significant increase in the PC 12 viability under HG conditions in comparison to pure AV; (4) conclusion: the nanocomplex of AV prepared to utilize natural polymers and antioxidants aided for high solubility of AV and exhibited desired neuroprotective activity.This can be one of the promisingstrategy to translate the AV nanocomplex with safety and efficacy in treating DN.

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Section: Introductionmentioning

confidence: 99%

Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells

Kurakula

N.²,

Patel³

et al. 2021

Gels

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“…19 Liposomes enhance the stability and activity of encapsulated materials by protecting them from the environment and liposomes can protect and improve the activity of bioactive compounds, which makes them ideal candidates for drug delivery and enhancing antitumor immunization y, [20][21][22][23][24][25] numerous research on the application of liposomes as protective membranes in food and pharmacological systems exist. [26][27][28][29] Several studies showed that liposomes can improve the bioavailability of lecithin and can be used as carriers in food systems. [30][31][32] We used the liposome technology because liposomes can protect embedding materials and thus improve the effectiveness and stability of C3G, which could be used as a carrier.…”

Section: Introductionmentioning

confidence: 99%

Comparison of anticancer activity and antioxidant activity between cyanidin-3-O-glucoside liposomes and cyanidin-3-O-glucoside in Caco-2 cells in vitro

et al. 2017

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“… 2 , 11 Recently, novel PDE5 inhibitors loaded NPs and various drug delivery systems have been developed. Hosny and Aldawsari 23 developed liposomes as multilamellar vesicles composed of cholesterol and more solid phospholipids containing avanafil to optimize the delivery of this drug across the skin ( Table 1 ). Incorporation of avanafil in liposomes improved the avanafil encapsulation efficiency, up to 95.61% EE achieved.…”

Section: Nanomedicine For Men Erectile Dysfunctionmentioning

confidence: 99%

“…The authors concluded that the avanafil liposomal transdermal delivery system is promising for ED therapy. 23 However, to date there are no clinical trials have confirmed the efficacy and safety of transdermal delivery of avanafil liposomes are available. Therefore, well-designed clinical studies are needed.…”

Section: Nanomedicine For Men Erectile Dysfunctionmentioning

confidence: 99%

Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review

2021

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Introduction The use of current available treatment for male erectile dysfunction (ED) has some limitations that are related to efficacy and adverse effects. Nanotechnology has been used as a new tool in medicine to improve these limitations and new medications potentially to alleviate and cure ED. Aim To review the currently literature on new nano medications for ED based on scientific and clinical studies, efficacy, safety, mechanisms of action, and to identify gaps for future research. Methods A comprehensive literature review was conducted via Google Scholar, Science Direct, and PubMed on English publications using different keywords such as “erectile dysfunction”, “emerging treatments”, “nanotechnology”, and “herbal medicine”. The retrieved papers were organized into groups according to the sections covered in this review paper. Main Outcomes Measures We reviewed novel ED treatments such as nanotechnological phosphodiesterase inhibitors, papaverine hydrochloride, sialorphin, adipose tissue-derived stem cells, sonic hedgehog, and herbal medicine. Results Numerous preclinical studies have addressed novel phosphodiesterase 5 inhibitors nanoparticle, and their recent delivery systems. Nitric oxide, sialorphin, sonic hedgehog, and herbal medicine loaded nanoparticles and nano adipose tissue-derived stem cells as a potential new treatment for ED. In addition, papaverine-containing nanoparticles have been reported. A limited number of randomized clinical studies have determined the mechanism of these treatments. Conclusion A literature review on the application of nanotechnology in ED therapy was successfully conducted. New nano medications are promising to treat ED. However, further studies are warranted to further assess their efficacy and safety. Masuku NP, Unuofin JO, Lebelo SL. Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review. Sex Med 2021;9:100420 .

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Avanafil Liposomes as Transdermal Drug Delivery for Erectile Dysfunction Treatment: Preparation, Characterization, and <i>In vitro, Ex vivo </i>and <i>In vivo</i> Studies

Cited by 13 publications

References 19 publications

Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells

Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells

Comparison of anticancer activity and antioxidant activity between cyanidin-3-O-glucoside liposomes and cyanidin-3-O-glucoside in Caco-2 cells in vitro

Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review

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