Avances en la búsqueda de la vacuna contra Helicobacter pylori

Urrego, J.; Otero, William; Trespalacios, Alba Alicia

doi:10.18273/revmed.v30n3-2017012

Cited by 1 publication

(1 citation statement)

References 89 publications

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“…Although vaccination must be highlighted as a preventive alternative, thus far, there is no vaccine available at the worldwide level to prevent infections by this bacterium. Considering the diversity of the immune response of individuals and the characteristics of H. pylori infection (large genetic heterogeneity of strains), there is still a long way to obtain an effective vaccine [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved

Parra-Sepúlveda

Sánchez-Alonzo

Olivares-Muñoz

et al. 2022

Foods

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Helicobacter pylori is a bacterium associated with various gastrointestinal diseases of high worldwide prevalence. Since probiotics are an emerging alternative to managing infection by this pathogenic bacterium, the present work evaluated, in a randomized double-blind study controlled by a placebo, if consuming Limosilactobacillus fermentum UCO-979C prevents H. pylori infection in humans. Participants consumed either L. fermentum UCO-979C-supplemented gelatin (67 participants) or placebo-supplemented gelatin (64 participants) once a day, five days per week for 12 weeks. H. pylori infection in the participants was controlled before and after the intervention detecting H. pylori antigens in stools. Regarding H. pylori-infected participants before the study, 100% remained infected at the end of the study in the placebo group, while 96.7% of those receiving the probiotic remained infected after the intervention. Most importantly, of the non-infected participants, 34.2% became infected and 65.8% remained non-infected in the placebo group, while 2.7% became infected and 97.3% remained as non-infected individuals in the intervened group. Therefore, consuming the L. fermentum UCO-979C strain significantly reduced H. pylori infection, demonstrating a 92.6% efficacy in avoiding infection by this pathogen in non-infected individuals; thus, this probiotic is an excellent candidate to prevent H. pylori infections in non-infected individuals.

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Section: Discussionmentioning

confidence: 99%