Avermectin induced inflammation damage in king pigeon brain

Chen, Lijie; Sun, Baohong; Qu, Jian Ping; Xu, Shiwen; Li, Shu

doi:10.1016/j.chemosphere.2013.09.058

Cited by 31 publications

(7 citation statements)

References 47 publications

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“…Abamectin is a mixture of B 1a and B 1b avermectins (Meister 1992). MN micronucleus, MMC mitomycin C (4.5 μg/ml, positive control in absence of S9 mix), BP benzo(a)pyrene (2 μg/ml, positive control in presence of S9 mix) * p<0.05, * * p<0.01; significant difference compared with control a Data are presented as mean ± SE of micronuclei/500 binucleated cytokinesis-blocked cells hepatocytes and brain neurons of King pigeon (Chen et al 2013;Zhu et al 2013). Ivermectin, a member of the avermectin family, and its commercial formulation Ivomec® originated cytotoxic effects in CHO K1 cells (Molinari et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Al‐Sarar

Abobakr

Bayoumi

et al. 2015

Environ Sci Pollut Res

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The cytotoxicity and genotoxicity of abamectin, chlorfenapyr, and imidacloprid have been evaluated on the Chinese hamster ovary (CHOK1) cells. Neutral red incorporation (NRI), total cellular protein content (TCP), and methyl tetrazolium (MTT) assays were followed to estimate the mid-point cytotoxicity values, NRI50, TCP50, and MTT50, respectively. The effects of the sublethal concentration (NRI25) on glutathione S-transferase (GST), glutathione reductase (GRD), glutathione peroxidase (GPX), and total glutathione content have been evaluated in the presence and absence of reduced glutathione (GSH), vitamin C, and vitamin E. The genotoxicity was evaluated using chromosomal aberrations (CA), micronucleus (MN) formation, and DNA fragmentation techniques in the presence and absence of the metabolic activation system, S9 mix. Abamectin was the most cytotoxic pesticide followed by chlorfenapyr, while imidacloprid was the least cytotoxic one. The glutathione redox cycle components were altered by the tested pesticides in the absence and presence of the tested antioxidants. The results of genotoxicity indicate that abamectin, chlorfenapyr, and imidacloprid have potential genotoxic effects on CHOK1 cells under the experimental conditions.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Al‐Sarar

Abobakr

Bayoumi

et al. 2015

Environ Sci Pollut Res

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“…The toxicity results of preliminary experiments completed in our laboratory revealed that oxidative stress, histopathological damages, inflammatory and apoptosis occured in pigeon after AVM exposure [15][16][17][18][19]. However, little is known regarding the effects of AVM on Hsps expression and histopathological changes in the pigeon spleen.…”

Section: Introductionmentioning

confidence: 89%

Effects of avermectin on heat shock proteins expression and histopathology in spleen tissues of pigeon

Liu

Wang

et al. 2014

Chemico-Biological Interactions

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“…Primers used in the present study to detect inflammatory cytokine expression in chickens treated with As 2 O 3 are shown in Additional file 1 [26]. GAPDH was considered a housekeeping gene and was used in this study as an internal reference.…”

Section: Methodsmentioning

confidence: 99%

“…IκBα and IκBβ are the main proteins involved in NF-κB activation and sustained activation, respectively. NF-κB is activated under inflammation stimulation and then moves to the nucleus, recognizes the promoter region and regulates the transcription of the pro-inflammatory genes inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) [24–26]. iNOS is a member of the NOS family and is widely distributed in a diverse number of nerve cells, whereas COX-2 is mainly found in specific neurons [27, 28].…”

Section: Introductionmentioning

confidence: 99%

Arsenic affects inflammatory cytokine expression in Gallus gallus brain tissues

Sun

Guo

et al. 2017

BMC Vet Res

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BackgroundThe heavy metal arsenic is widely distributed in nature and posses a serious threat to organism’s health. However, little is known about the arsenic-induced inflammatory response in the brain tissues of birds and the relationship and mechanism of the inflammatory response. The purpose of this study was to explore the effects of dietary arsenic on the expression of inflammatory cytokines in the brains of Gallus gallus.ResultsSeventy-two 1-day-old male Hy-line chickens were divided into a control group, a low arsenic trioxide (As2O3)-treated (7.5 mg/kg) group, a middle As2O3-treated (15 mg/kg) group, and a high As2O3-treated (30 mg/kg) group. Arsenic exposure caused obvious ultrastructural changes. The mRNA levels of the transcription factor nuclear factor-κB (NF-κB) and of pro-inflammatory cytokines, including inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E synthase (PTGEs), in chicken brain tissues (cerebrum, cerebellum, thalamus, brainstem and myelencephalon) on days 30, 60 and 90, respectively, were measured by real-time PCR. The protein expression of iNOS was detected by western blot. The results showed that after being treated with As2O3, the levels of inflammatory-related factor NF-κB and pro-inflammatory cytokines in chicken brain tissues increased (P < 0.05).ConclusionsArsenic exposure in the chickens triggered host defence and induced an inflammatory response by regulating the expression of inflammatory-related genes in the cerebrum, cerebellum, thalamus, brainstem and myelencephalon. These data form a foundation for further research on arsenic-induced neurotoxicity in Gallus gallus.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-017-1066-8) contains supplementary material, which is available to authorized users.

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Avermectin induced inflammation damage in king pigeon brain

Cited by 31 publications

References 47 publications

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Effects of avermectin on heat shock proteins expression and histopathology in spleen tissues of pigeon

Arsenic affects inflammatory cytokine expression in Gallus gallus brain tissues

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