Avian Stress-Related Transcriptome and Selenotranscriptome: Role during Exposure to Heavy Metals and Heat Stress

Seremelis, Isidoros; Danezis, Georgios P.; Pappas, Athanasıos C.; Zoidis, Evangelos; Fegeros, K.

doi:10.3390/antiox8070216

Cited by 14 publications

(11 citation statements)

References 155 publications

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“…Several studies have confirmed the relationship between the inflammatory response of the immune organs and the expression of inflammatory cytokines [ 5 ]. The most effective role played by TNF-α, as the most important cytokine, is related to its potent cytoprotective and antioxidant activity in response to injuries [ 5 , 46 ], and activating lymphocytes and neutrophils to produce the other cytokines [ 47 ]. The TNF-α was down-regulated in the AST80 treatment but not in the AST40 or AST20 treatments.…”

Section: Discussionmentioning

confidence: 99%

Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature

Hosseindoust

Oh²,

et al. 2020

Antioxidants

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This study investigated the effect of dietary astaxanthin (AST) on the meat quality, antioxidant status, and immune response of chickens exposed to heat stress. Four hundred and eighty male broilers were assigned to four treatments including AST0, AST20, AST40, and AST80 with 0, 20, 40, and 80 ppm astaxanthin supplementation levels, respectively. There was a linear decrease of malondialdehyde (MDA) in leg muscle. Catalase and superoxide dismutase levels in the plasma were linearly increased. There was a linear increase in the level of total antioxidant capacity in the leg muscle. The 3-ethylbenzothiazoline-6-sulfonate reducing activity of leg muscle was significantly increased in the AST80 treatment. The AST40 treatment showed an increase in 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity of leg muscles. Breast meat redness and yellowness were linearly increased. The astaxanthin-supplemented treatments exhibited lower drip loss and MDA concentration of leg muscle compared with the AST0 treatment at days 3 and 9 of storage. Supplementation of 40 or 80 mg/kg astaxanthin significantly decreased heat shock protein (HSP)27, HSP70, tumor necrosis factor alpha, and interleukin-6 expression in the livers. The feather corticosterone was significantly lower in the astaxanthin-supplemented treatments than in the AST0 treatment. In conclusion, astaxanthin decreased the hyperthermic stress level and improved meat quality, and antioxidant status of chickens exposed to heat stress.

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Section: Discussionmentioning

confidence: 99%

Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature

Hosseindoust

Oh²,

et al. 2020

Antioxidants

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“…The main environmental stressors are inadequate temperature, poor ventilation (high levels of ammonia and CO 2 ), increased dust levels, and insufficient lighting. Nutritional factors include the presence of mycotoxins in feed; oxidized fats; toxic metals such as lead (Pb), cadmium (Cd), and mercury (Hg); whether there is an unbalanced diet (deficiencies in nutrients and trace elements such as Se, Zn, Mn, Cu, and vitamin overdosing); poor water quality; and the extensive use of coccidiostats and other drugs through feed or water (i.e., the risk of reducing antioxidant absorption) [ 60 , 61 ]. Internal stressors include vaccinations, as well as bacterial and viral infections.…”

Section: Supplementation Of Natural Antioxidants In the Diet Of Broil...mentioning

confidence: 99%

Nutrigenomics of Natural Antioxidants in Broilers

Kouvedaki,

Pappas,

Surai

et al. 2024

Antioxidants

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The broiler industry supplies high-quality animal protein to the world. The ban of antibiotics as growth promoters has opened the way for plenty of phytochemicals and antioxidants to be explored. This study summarizes the use of natural antioxidants in a broiler diet as a way through which to deal with stressors, as well as their effects on the expression of various genes. The transcriptional factors and genes involved in the regulation of redox homeostasis are described and emphasis is placed on nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B. Sources such as fruits, vegetables, spices, mushrooms, and algae contain numerous natural antioxidant compounds. The antioxidant activity of these compounds has also been confirmed at the genome level. This study focuses on the regulation of oxidative stress-related genes, as well as on genes that regulate the inflammatory response, apoptosis, response to heat stress, lipid metabolism, and the intestinal barrier status. The natural compounds presented include, but are not limited to, the following: rutin, lycopene, magnolol, genistein, hesperidin, naringin, quercetin, curcumin, bisdemethoxycurcumin, resveratrol, astaxanthin, squalene, pterostilbene, protocatechuic acid, taraxasterol, myricetin, and proanthocyanidins. Several studies have revealed a dose-dependent action. Future studies should focus on the role of phytogenic compounds as antibiotic alternatives in relation to gut microbiota and their role in eubiosis.

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“… Changes in performance (production efficiency): Heat stress greatly impact the feeding pattern of broiler chickens and this subsequently results into 33% decrease in body weight gain (Lara and Rostagno 2013) which further impairs the production efficiency of the chickens (Toyomizu et al 2019;Sumanu et al 2021b).  Immunocompetence: The immune responses of broiler chickens are impaired during heat stress due to the presence of excessive reactive oxygen species (ROS) that cause cellular damage (Seremelis et al 2019). The body's defence mechanisms are weakened over a period of time due to the increased level of pro-inflammatory cytokines in circulation.…”

Section: Effects Of Heat Stress On the Performance Of Broiler Chickensmentioning

confidence: 99%

Adverse effects of heat stress during summer on broiler chickens production and antioxidant mitigating effects

et al. 2022

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Broiler chicken meat is a good source of protein consumed universally, and is one of the most commonly farmed species in world. In addition to providing food, poultry non-edible byproducts also have value. A major advantage of broiler chicken production is their short production cycle, which results in a greater rate of production in comparison to other species. However, as with any production system, there are constraints in broiler production with one of the most pressing being energy requirements to keep the birds warm as chicks and cool later in the growth cycle, as a result of the cost needing mechanical heating and cooling. While this is feasible in more advanced economies, this is not readily affordable in developing economies. As a result, farmers rely on natural ventilation to cool the rearing houses, which generally becoming excessively warm with the resultant heat stress on the birds. Since little can be done without resorting to mechanical ventilation and cooling, exploring the use of other means to reduce heat stress is needed. For this review, we cover the various factors that induce heat stress, the physiological and behavioral responses of broiler chickens to heat stress. We also look at mitigating the adverse effect of heat stress through the use of antioxidants which possess either an anti-stress and/or antioxidant effects.

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Avian Stress-Related Transcriptome and Selenotranscriptome: Role during Exposure to Heavy Metals and Heat Stress

Cited by 14 publications

References 155 publications

Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature

Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature

Nutrigenomics of Natural Antioxidants in Broilers

Adverse effects of heat stress during summer on broiler chickens production and antioxidant mitigating effects

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