Avocado peel extract loaded on chitosan nanoparticles alleviates urethane toxicity that causes lung cancer in a mouse model

Sahyon, Heba A.; El‐Shafai, Nagi M.; Elnajjar, Noha; Althobaiti, Fayez; Aldhahrani, Adil; Alharbi, Nadaa S; Shoier, Abdel Ghany F; El‐Mehasseb, Ibrahim M.

doi:10.1016/j.ijbiomac.2023.123633

Cited by 9 publications

(4 citation statements)

References 52 publications

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“…(2023) stated that avocado skin improves lung cancer in mice due to its antioxidant properties. [ 110 ] Zhang et al. (2022) stated that naringenin, which is a type of flavonoid in fruits, reduces inflammation and apoptosis in lung tissue caused by Ag NPs.…”

Section: Discussionmentioning

confidence: 99%

“…[109] The results showed that alumina nanoparticles cause lung cell inflammation, while Absinthium artemisia extract improves the severity of injuries due to the plant's antioxidant properties. Sahyon et al (2023) stated that avocado skin improves lung cancer in mice due to its antioxidant properties. [110] Zhang et al (2022) stated that naringenin, which is a type of flavonoid in fruits, reduces inflammation and apoptosis in lung tissue caused by Ag NPs.…”

Section: Lung Histological Damagementioning

confidence: 99%

“…Sahyon et al (2023) stated that avocado skin improves lung cancer in mice due to its antioxidant properties. [110] Zhang et al (2022) stated that naringenin, which is a type of flavonoid in fruits, reduces inflammation and apoptosis in lung tissue caused by Ag NPs. [111] Chniguir et al (2019) stated that (Syzygium aromaticum) extract ameliorates lipopolysaccharide-induced lung inflammation.…”

Section: Lung Histological Damagementioning

confidence: 99%

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Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Sayadi,

Fahoul,

Kharkan

et al. 2023

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The aim of this study is to investigate the protective effects of Elaeagnus angustifolia fruit extract (EAFE) on hematology, biochemical parameters, liver enzymes and damage of different tissues of male mice exposed to graphene oxide nanoparticles (GO NPs). In this research, 48 mice were divided into six groups. Hematology parameters including red blood cells (RBC), white blood cells (WBC), hematocrit (Ht), and hemoglobin (Hb), biochemical parameters such as cholesterol, triglyceride, glucose, protein, albumin, creatinine and bilirubin, liver enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) and histological damage of liver, kidney, lung and testis of mice were investigated. The results show that GO NPs in both concentrations (30 and 60 mg/kg/bw) decrease the number of RBC compared to the control group (p < 0.05). EAFE has no effect on RBC count while EAFE in combination with both concentrations of 30 and 60 mg/kg/bw GO NPs significantly (p < 0.05) improves the RBC count of mice. Also, the results show that EAFE improves the number of WBC, Ht, Hb, and biochemical parameters of mice exposed to different concentrations of GO NPs. A series of morphological changes were observed in the RBC of rats exposed to 60 mg/kg/bw GO NPs, including Dacrocyte, Poikilocyte and Schistocyte, which EAFE can improve the morphological changes caused in RBC. A series of histological damages such as degeneration and dilatation in the central vein in liver tissue, thickening and inflammatory cell infiltration in the renal capsule, peribronchiolar inflammatory cell infiltration and congestion in peribronchiolar blood vessels in lung tissue and decrease in the height of the germinal epithelium and a decrease in the population of spermatozoid cells in spermatogenic cells were observed in the testis of mice exposed to 60 mg/kg/bw GO NPs. The results show that EAFE can improve the damage caused by GO NPs in the liver, kidney and lung tissues, while it has no effect on the damage in the mice testis tissue. Therefore, GO NPs cause damage in the blood and different tissues of mice, and the use of EAFE can be effective in improving these damages.

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Section: Discussionmentioning

confidence: 99%

Section: Lung Histological Damagementioning

confidence: 99%

Section: Lung Histological Damagementioning

confidence: 99%

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Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Sayadi,

Fahoul,

Kharkan

et al. 2023

Nano Select

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“… 119 Additionally, chitosan-based materials have been used for different medical purposes like wound healing, 120 drug delivery, 121 and anticancer activity. 122 Nevertheless, it is difficult to conclude that polymers are always non-toxic. For example, cellulose nanocrystals from different sources did not show developmental or mortality effects on zebrafish, but some oxidative stress at a 0.01 mg L −1 dose was observed.…”

Section: Potential Impacts Of Polymer-based Nanocomposite Adsorbents ...mentioning

confidence: 99%

Polymer-based nanocomposite adsorbents for resource recovery from wastewater

Ahmed,

Mekonnen,

Mekonnen

2023

RSC Adv.

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Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy

El-Shafai,

Mostafa,

Ramadan

et al. 2024

Bioorganic Chemistry

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Avocado peel extract loaded on chitosan nanoparticles alleviates urethane toxicity that causes lung cancer in a mouse model

Cited by 9 publications

References 52 publications

Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Polymer-based nanocomposite adsorbents for resource recovery from wastewater

Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy

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