Avoidance of steroids by the early use of infliximab and 6-mercaptopurine in an adolescent with active Crohn's colitis

Infliximab dependency in pediatric Crohnʼs disease: Long-term follow-up of an unselected cohort

“…With respect to efficacy, it has been suggested that the use of infliximab is more effective early in the disease process instead of waiting until conventional therapy has failed. The early stages of immune‐mediated disease may be more susceptible to immunomodulation and the natural history of CD may be altered 8, 9. In children prolonged duration of response after infliximab therapy is reported when the drug was initiated early in the disease course 10, 11.…”

The use of infliximab in South‐east Asian children with severe Crohn's disease

“…Early use of infliximab can reduce the requirement of corticosteroids and its eventual side‐effects 8 . In this case report, case 3 received infliximab early in the course of illness to allow early withdrawal of corticosteroids.…”

Sudden onset of Multiple nevi after administration of 6‐mercaptopurine in an adult with Crohn's disease: a case report

“…6‐mercaptopurine is one of a large series of purine analogs interfering with nucleic acid biosynthesis, and has activity against human leukemia. It is indicated for remission, induction and maintenance therapy of acute lymphatic leukemia, acute myelogenous leukemia and for treatment of active Crohn's disease 3,4 …”

“…We recently observed a 27‐year‐old female patient who developed numerous benign melanocytic nevi during a 20‐month period while taking 6‐mercaptopurine for Crohn's disease. The appearance of many nevi was worrisome to the patient from a cosmetic and medical perspective (given the higher risk of melanoma associated with large numbers of nevi) 3 …”