Avoiding early postoperative complications in liver surgery. A multivariate analysis of 254 patients consecutively observed

Alfieri, Sergio; Carriero, Canio; Caprino, Paola; Giorgio, Andrea Di; Sgadari, Antonio; Crucitti, F; Doglietto, GB

doi:10.1016/s1590-8658(01)80089-x

Cited by 39 publications

(28 citation statements)

References 19 publications

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“…15 The kidney and liver parenchymal tissue can also be difficult to suture with risk of high blood loss. 16 Our group has recently developed a biocompatible and sutureless adhesive for peripheral nerve repair; 17 this adhesive is based on chitosan and is bonded photochemically to tissue by a green laser without causing thermal damage. 18,19 In this study, we succeeded in modifying the adhesive surface with nanopillars to further enhance the strength of tissue bonding.…”

Section: Introductionmentioning

confidence: 99%

Gecko-inspired chitosan adhesive for tissue repair

et al. 2016

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The advent of nanotechnology has opened the possibility of fabricating nanoscopic pillars on the surface of polymeric films mimicking the Gecko's foot, in an attempt to increase their adhesive capabilities enhanced by van der Waals forces. However, these forces are considerably weakened in a wet physiological environment. To circumvent this loss in force, current biocompatible adhesives with nanopillars require complex multiple-step fabrication, including an extra layer of adhesive coating to stabilize tissue bonding under physiological conditions. In this report, we describe a simple one-step fabrication process of a single-layer chitosan film that has pillars with base diameter in the range of 100-600 nm and a height of~70 nm. The nanostructured adhesive is laser-bonded to tissue and does not require pillar coating to enhance bonding in water. In comparison with a 'flat' adhesive (without pillars), the nanostructured adhesive bonded significantly stronger to tissue under either stress or pressure. Atomic force spectroscopy also confirmed the superior bonding capability of the nanostructured adhesive. This study demonstrates a one-step fabrication technique to produce a monolayer gecko-inspired adhesive that is biocompatible and bonds effectively to tissue.

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Section: Introductionmentioning

confidence: 99%

Gecko-inspired chitosan adhesive for tissue repair

et al. 2016

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“…Both morbidity and mortality after liver resection is significantly related to the intraoperative blood loss [1][2][3][4][5][6]. The predisposition to diffuse bleeding is caused by extreme vascularity, particularly because of the hepatic sinusoidal structure, which is not capable of smooth-mus cle contraction to induce vasoconstriction [7].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a new carrier-bound fibrin sealant versus argon beamer as haemostatic agent during liver resection: a randomised prospective trial

Frilling

Stavrou

Mischinger

et al. 2005

Langenbecks Arch Surg

167

121

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“…In hepatectomy, intraoperative bleeding is known to be an important prognostic indicator of both postoperative morbidity and mortality [1][2][3]. Therefore, it is important to reduce intraoperative bleeding as much as possible.…”

Section: Introductionmentioning

confidence: 99%