Avoiding pits on the energy landscape – alternative strategies for stabilizing nateglinide co-amorphous systems

Silva, Joana F. C.; Jasiurkowska-Delaporte, Małgorzata; Pereira Silva, Pedro S.; Silva, Manuela Ramos; Eusébio, M. Ermelinda S.; Rosado, Mário T. S.

doi:10.1039/d4ce00195h

CrystEngComm

2024

DOI: 10.1039/d4ce00195h

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Avoiding pits on the energy landscape – alternative strategies for stabilizing nateglinide co-amorphous systems

Joana F. C. Silva,

Małgorzata Jasiurkowska-Delaporte,

Pedro S. Pereira Silva

et al.

Abstract: Nateglinide is a prolific polymorph former. Cryo-milling and quench cooling were explored as alternatives to stabilize its co-amorphous systems with ranolazine and tryptophan, and their molecular dynamics of relaxation investigated.

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Avoiding pits on the energy landscape – alternative strategies for stabilizing nateglinide co-amorphous systems

Abstract: Nateglinide is a prolific polymorph former. Cryo-milling and quench cooling were explored as alternatives to stabilize its co-amorphous systems with ranolazine and tryptophan, and their molecular dynamics of relaxation investigated.

Cited by 0 publications

References 54 publications

No citations

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