Axial Length Increases and Related Changes in Highly Myopic Normal Eyes With Myopic Complications in Fellow Eyes

Takahashi, Akiko; Ito, Yasuki; Iguchi, Yoshinori; Yasuma, Tetsuhiro; Ishikawa, Kohei; Terasaki, Hiroko

doi:10.1097/iae.0b013e318214d094

Cited by 44 publications

(40 citation statements)

References 31 publications

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“…Our earlier report showed that the progression of axial elongation was most significantly associated with superior RPE curvature. 38 Ikuno et al 34 reported that the nasal posterior staphyloma height was significantly greater in eyes with a mCNV than in eyes without a mCNV.…”

Section: Discussionmentioning

confidence: 99%

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Scleral thickness in highly myopic eyes measured by enhanced depth imaging optical coherence tomography

Hayashi

Ito

Takahashi

et al. 2013

Eye

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Purpose The purpose of this study was to determine the subfoveal scleral thickness in highly myopic eyes by enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) and to identify the ocular parameters significantly associated with the scleral thickness. Methods The subfoveal scleral thickness of myopic eyes (Z À 8 diopters (D) or axial length Z26.5 mm) was examined by EDI-OCT. The correlations between the thickness and the best-corrected visual acuity (BCVA), refractive error, axial length (AL), the subfoveal retinal thickness, choroidal thickness, and posterior staphyloma height 2 mm from the fovea were investigated. Results A total of 75 eyes of 54 patients (21 men, 33 women; mean age, 62.3 ± 11.3 years; mean AL, 30.2 ± 1.68 mm) were studied. Eighteen eyes had no pathological retinochoroidal lesions, and 57 eyes had retinochoroidal lesion, that is, myopic schisis, choroidal neovascularization, and other retinochoroidal pathologies. The mean subfoveal scleral thickness was 284.0±70.4 lm, and the thickness was significantly correlated negatively with the absolute value of the nasal and overall average posterior staphyloma height (Po0.05 and Po0.01, respectively). The subfoveal scleral thickness was also significantly correlated negatively with the relative value of the superior, nasal, and overall average posterior staphyloma height (Po0.05, Po0.01, and Po0.001, respectively). Stepwise analyses showed that the factor most significantly associated with the scleral thickness was the average relative posterior staphyloma height (F ¼ 16.0, Po0.001). The scleral thickness was not significantly different between eyes with and without myopic retinochoroidal pathologies (P40.05). Conclusion Posterior staphyloma formation was a key factor associated with a posterior scleral thinning in highly myopic eyes.

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Section: Discussionmentioning

confidence: 99%

“…[28][29][30][31][32][33][34][35][36][37] In our earlier study on the choroid of highly myopic eyes, we detected a thinner sclera by spectraldomain OCT because both the retina and choroid were very thin. 38 This meant that we should be able to investigate the morphology of the sclera in highly myopic eyes.…”

Section: Introductionmentioning

confidence: 99%

Scleral thickness in highly myopic eyes measured by enhanced depth imaging optical coherence tomography

Hayashi

Ito

Takahashi

et al. 2013

Eye

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“…Histological studies show that, in the area of the crescent, there is either partial or complete absence of the choroid, Bruch's membrane, and the RPE [3]. In our earlier study, we showed that an increase in the height of the posterior staphyloma in highly myopic healthy adult eyes with myopic complications in the fellow eyes was the most likely cause of the increase in the axial length [4]. The results also suggest that there might be an increase in the size of the peripapillary crescent as the axial length increased.…”

Section: Introductionmentioning

confidence: 98%

Peripapillary crescent and related factors in highly myopic healthy eyes

et al. 2012

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“…Such complications are typically caused by excessive elongation of the eyeball, which may also cause decreased choroidal thickness (CT) compared with emmetropic eyes (EE) (4,5) . Until recently, the utility of in vivo choroidal imaging was considered relatively poor.…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickness variation in highly myopic eyes during the water drinking test

Germano¹,

Hatanaka²,

Susanna³

2016

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate variations in choroidal thickness (CT) during the water drinking test (WDT) in emmetropic eyes (EE) and highly myopic eyes (ME) using spectral-domain optical coherence tomography (SD-OCT). Methods: Clinical trial performed at a tertiary care hospital comprising 30 randomly selected eyes. The WDT and SD-OCT macular scans were performed 10 and 45 min after water ingestion in 15 myopic and 15 EE of 15 healthy patients in each group. Primary study outcomes were average macular CT measured by SD-OCT and intraocular pressure (IOP) during the WDT. Results: The mean spherical equivalent refraction was 0.15 ± 0.24 D in emmetropic and -7.1 ± 1.75 D in ME (p<0.001). No statistical differences between EE and ME were observed during the WDT response. EE had higher CT compared with ME at the fovea (361.4 ± 55.4 vs 257.9 ± 95.3; p<0.001), 3 mm nasal to the fovea (158.0 ± 71.8 vs 122.5 ± 54.5; p=0.047), and 3 mm temporally to the fovea (310.6 ± 52.4 vs 247.6 ± 90.1; p=0.05). Regarding CT variation, significant differences in foveal CT at 10 min after water ingestion were observed in both EE and ME, with no statistically significant difference observed between groups. A moderate correlation between IOP peak during the WDT and CT was demonstrated in ME (r=0.52; p=0.04). Conclusions:No statistically significant differences in CT variation during the WDT were observed between EE and ME, indicating similar behavior of the choroidal bed during the WDT in both groups. Further, CT was thinner in highly ME, with CT variation unable to explain elevations in IOP observed during the WDT.

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Axial Length Increases and Related Changes in Highly Myopic Normal Eyes With Myopic Complications in Fellow Eyes

Abstract: Our results indicate that the AL can increase significantly in highly myopic normal adult eyes during a 1-year interval, and the increase in the posterior staphyloma height is the most likely cause for the increased AL.

Cited by 44 publications

References 31 publications

Scleral thickness in highly myopic eyes measured by enhanced depth imaging optical coherence tomography

Scleral thickness in highly myopic eyes measured by enhanced depth imaging optical coherence tomography

Peripapillary crescent and related factors in highly myopic healthy eyes

Choroidal thickness variation in highly myopic eyes during the water drinking test

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