Axillary lymph node metastases from thyroid carcinoma: Report of seven cases

Suehiro, Atsushi; Nagahara, Kunihiko; Moritani, Sueyoshi; Omori, Koichi

doi:10.1016/j.anl.2020.10.016

Cited by 3 publications

(5 citation statements)

References 15 publications

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“…[ 146 ]. This is also depicted in our review, where few patients went disease-free [ 36 , 39 , 45 , 52 , 53 , 54 , 56 , 58 , 59 , 64 , 65 , 68 , 71 , 72 , 87 , 96 , 99 , 103 , 104 , 106 , 108 , 117 , 118 ]. Distant metastases represent the most significant cause of death in PDTC, with the majority of patients succumbing to the disease.…”

Section: Discussionsupporting

confidence: 78%

“…Since cytological diagnosis of PDTC based on FNAC is challenging, our review has shown that some patients underwent a hemithyroidectomy or subtotal thyroidectomy with a completion thyroidectomy after histological diagnosis [ 38 , 44 , 52 , 54 , 59 , 65 , 69 , 85 , 103 , 104 , 107 , 108 , 115 , 117 ], but the majority of them were submitted to a total thyroidectomy as the initial operation [ 40 , 41 , 42 , 43 , 46 , 48 , 49 , 50 , 51 , 53 , 54 , 55 , 56 , 58 , 60 , 61 , 62 , 64 , 67 , 68 , 69 , 72 , 73 , 75 , 79 , 80 , 81 , 82 , 85 , 86 , 88 , 89 , 90 , 91 , 92 , 93 , 95 , 96 , 100 , 101 ,…”

Section: Discussionmentioning

confidence: 99%

“…However, it remains debatable whether the cut-off value for the poorly differentiated area should be reported in PDTC tumors. Based on our review, several cases had a multiconstituent histology of well-differentiated (mostly PTC and FTC) with poorly differentiated areas without elaborating on their extent [ 49 , 50 , 55 , 56 , 58 , 69 , 71 , 72 , 73 , 91 , 100 , 103 , 107 , 109 , 112 , 113 ]. Interestingly, the Japanese society of thyroid surgery emphasizes that the presence of a poorly differentiated component should be acknowledged as a distinct entity from DTC, independent of its histological extent within the tumor [ 128 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

Violetis,

Konstantakou,

Spyroglou

et al. 2024

JPM

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Background: Poorly differentiated thyroid carcinoma (PDTC) has an intermediate prognosis between indolent well-differentiated thyroid carcinoma (TC) and anaplastic carcinoma. Herein, we present a case report with a PDTC component, along with a systematic review of the literature. Case Report: We report a case of a 45-year-old man diagnosed with a PDTC component, along with hobnail and tall-cell variant features positive for BRAFV600E mutation, after a total thyroidectomy and neck dissection. Radioactive iodine (RAI)-131 therapy was applied, but an early recurrence led to complementary surgeries. The anti-Tg rise, the presence of new lymph nodes, and the negative whole-bodyradioiodine scan were suggestive of a radioiodine-resistant tumor. Lenvatinib, sorafenib, dabrafenib/trametinib, cabozantinib and radiotherapy were all administered, controlling the tumor for a period of time before the patient ultimately died post-COVID infection. Systematic Review: We searched PubMed, Scopus, and WebofScience to identify studies reporting clinicopathological characteristics, molecular marker expression, and management of non-anaplastic TC with any proportion of PDTC in adult patients. Of the 2007 records retrieved, 82were included in our review (PROSPERO-ID545847). Conclusions: Our case, together with the systematic review, imply that a combination of molecular-targetedtreatments may be safe and effective in patients with RAI-resistantBRAF-mutated advanced PDTC when surgery has failed to control tumor progression.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

Violetis,

Konstantakou,

Spyroglou

et al. 2024

JPM

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“…In addition, this patient's axillary lesion is easily mistaken for axillary lymph node metastasis from thyroid carcinoma, because axillary lymph node metastasis is not uncommon. 11 Clinicians should be aware of the possibility of false-positive uptake in the axillary region when evaluating 131 I-WBS. This awareness can help to identify positive findings on 131 I-WBS.…”

Section: Figurementioning

confidence: 99%

“…However, it is rare to observe radioiodine uptake in the epidermal cyst. In addition, this patient’s axillary lesion is easily mistaken for axillary lymph node metastasis from thyroid carcinoma, because axillary lymph node metastasis is not uncommon 11 . Clinicians should be aware of the possibility of false-positive uptake in the axillary region when evaluating 131 I-WBS.…”

mentioning

confidence: 98%

Epidermal Cyst Mimicking Thyroid Cancer Metastasis

et al. 2022

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A 26-year-old woman with pulmonary metastasis of thyroid cancer underwent a total thyroidectomy and cervical lymph node dissection followed by 2 courses of 131 I therapy. The posttherapeutic whole-body scan after the second dose of 131 I therapy showed diffuse tracer uptake in both lungs. Besides this, there is a local abnormal radiotracer uptake in the left axillary region. SPECT/CT images localized this abnormal radioactivity in a subcutaneous, oval-shaped, approximately 2.2-cm slightly hyperdense lesion, which was pathologically confirmed as an epidermal cyst.

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Case report: Lymph node metastases of breast cancer and thyroid cancer encountered in axilla

Zhang

Feng

et al. 2022

Front. Oncol.

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Occurrences of breast cancer and thyroid cancer metachronously or synchronously are common for women, but axillary lymph node metastasis from both cancers is rarely seen. We report a patient who had two metastatic lymph nodes from papillary thyroid carcinoma after axillary lymph node dissection with mastectomy. Papillary thyroid carcinoma diagnosis was ensured after thyroidectomy. A literature review revealed that even the co-occurrence of breast cancer and thyroid cancer is not rare, but the etiology behind this phenomenon is not elucidated well. Genetic disorders, thyroid dysfunction, and hormone receptors may be relevant. Considering the rareness of axillary lymph node metastasis of thyroid cancer, adjuvant therapy and surgery treatment for this kind of case should be considered elaborately.

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Axillary lymph node metastases from thyroid carcinoma: Report of seven cases

Cited by 3 publications

References 15 publications

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

Epidermal Cyst Mimicking Thyroid Cancer Metastasis

Case report: Lymph node metastases of breast cancer and thyroid cancer encountered in axilla

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