Axillary lymph node metastases in adenoid cystic carcinoma of the breast. A rare finding

SPILIOPOULOS, D

doi:10.11138/gchir/2015.36.5.209

Cited by 8 publications

(9 citation statements)

References 31 publications

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“…For grade 1, wide local excision is recommended; for grade 2, simple mastectomy is recommended and for grade 3, mastectomy with axillary lymph node dissection is recommended [ 3 ]. Although some have indicated that lymph node involvement is uncommon and, therefore, resection is unnecessary, others have suggested that it may benefit high-grade tumors [ 2 , 7 , 8 ]. A modified radical mastectomy was performed in our patient’s case, and the patient refused adjuvant chemotherapy and radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

Gillie

Kmeid

Asarian

et al. 2020

Journal of Surgical Case Reports

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Adenoid cystic carcinoma (ACC) of the breast is a rare malignancy, accounting for 0.1–1% of breast cancers. Histologically breast ACC is similar to ACC’s found in salivary tissue and is a triple-negative breast cancer with an uncharacteristically favorable prognosis and low incidence of metastasis. Most cases present as a painful, palpable mass; however, asymptomatic cases found on screening mammograms have also been noted. Core needle biopsy or excisional biopsy is necessary for definitive diagnosis of breast ACC. Immunohistochemistry of these cancers can differentiate breast ACC from masses with similar histology, such as invasive cribriform carcinoma and collagenous spherulosis. There is no well-established treatment guideline for ACC; however, it has been noted that reoccurrence and metastasis are noted more in cases of local resection than mastectomy.

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Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

Gillie

Kmeid

Asarian

et al. 2020

Journal of Surgical Case Reports

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“…Axillary lymph node metastases have been reported in association with ACC but are exceptionally rare . Distant metastases also are uncommon, although cases with spread to the lung, vertebrae, and liver have been reported .…”

Section: Introductionmentioning

confidence: 99%

Is axillary surgery beneficial for patients with adenoid cystic carcinoma of the breast?

Welsh

Keeney

Hoskin

et al. 2017

Journal of Surgical Oncology

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“…Our clinical review results are reported in (Table 1). Mean LRFS reported by case reports was 24 months (range 20-48) [3,4,8,[10][11][12]. Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%) [2,5,[13][14][15][16].…”

Section: Resultsmentioning

confidence: 99%

“…Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%) [2,5,[13][14][15][16]. Mean OS reported in case reports was 30 months (range 12-84) [3,4,8,[10][11][12]. Mean 5-years OS reported in retrospective series was 89.7% [2,16,17].…”

Section: Resultsmentioning

confidence: 99%

The role of radiotherapy (RT) in the treatment of Adenoid Cystic Carcinoma of the Breast: case report of RT retreatment and literature review

Smaniotto¹,

Terribile²,

Marazzi³

et al. 2019

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This study reviews the recent literature on the role of definitive radiotherapy (RT) in the management of adenoid cystic carcinoma of the breast (ACCB) and presents comprehensive data on clinical outcomes. A case report of radiotherapy retreatment in ACCB is reported for first time in literature. Methods: The authors performed a literature review using PubMed (1981-2019) to identify all studies that match with keywords. Inclusion criteria were articles reporting patients underwent radiotherapy after ACCB diagnosis with follow up reporting. Data analyzed were number of pts, age, study design, multimodality treatment management with radiotherapy schedule, stage of disease, pathological risk factors, local relapse free survival (LFRS), metastases free survival (MFS) and overall survival (OS). Results: Of the 60 identified studies, 15 met the inclusion criteria. All studies had a retrospective design. Overall, 967 patients (median, 64; range, 1-478) were included. A high heterogeneity was found across studies in terms of pathological features available, local approach in multimodality management, adjuvant RT administration, and reported outcomes. Mean LRFS reported by case reports was 24 months (range 20-48). Mean DFS reported by case series and retrospective series was 87.9% (range 69-100%). Mean OS reported in case reports was 30 months (range 12-84). Mean 5-years OS reported in retrospective series was 89.7%. Mean 10-years OS reported in retrospective series was 78.7%. In some retrospective series radiotherapy was found significantly related to local control (p=0.03) and with an absolute survival benefit of 9% at 5 year and of 21% at 10 years (p=0.005). Conclusion and implications for practice: To our knowledge this is the first report on radiotherapy retreatment in ACCB local relapse. This study also reviews the recent literature on the role of adjuvant RT in the management of ACCB and presents comprehensive data on long-term clinical outcome. Some significant results about RT are improvement in local control and survival benefit also since at 10 years in some series. Further studies are needed to confirm these results.

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Axillary lymph node metastases in adenoid cystic carcinoma of the breast. A rare finding

Cited by 8 publications

References 31 publications

Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

Is axillary surgery beneficial for patients with adenoid cystic carcinoma of the breast?

The role of radiotherapy (RT) in the treatment of Adenoid Cystic Carcinoma of the Breast: case report of RT retreatment and literature review

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