2015
DOI: 10.1523/jneurosci.3397-14.2015
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Axonal Amphoterin mRNA Is Regulated by Translational Control and Enhances Axon Outgrowth

Abstract: High mobility group (HMG) proteins concentrate in the nucleus, interacting with chromatin. Amphoterin is an HMG protein (HMGB1) that has been shown to have extranuclear functions and can be secreted from some cell types. Exogenous amphoterin can increase neurite growth, suggesting that the secreted protein may have growth promoting activities in neurons. Consistent with this, we show that depletion of amphoterin mRNA from cultured adult rat DRG neurons attenuates neurite outgrowth, pointing to autocrine or par… Show more

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Cited by 32 publications
(50 citation statements)
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“…Defining the axonal localization motif of Nrn1 mRNA -We had previously shown that intra-axonal translation of Hmgb1 and Nrn1 supports axon growth (25,36). Axonal localization of Hmgb1 mRNA is driven through a 60 nt motif in its 3'UTR, and the Hmgb1 mRNA is constitutively transported into sensory axons (36).…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Defining the axonal localization motif of Nrn1 mRNA -We had previously shown that intra-axonal translation of Hmgb1 and Nrn1 supports axon growth (25,36). Axonal localization of Hmgb1 mRNA is driven through a 60 nt motif in its 3'UTR, and the Hmgb1 mRNA is constitutively transported into sensory axons (36).…”
Section: Resultsmentioning
confidence: 99%
“…Axonal localization of Hmgb1 mRNA is driven through a 60 nt motif in its 3'UTR, and the Hmgb1 mRNA is constitutively transported into sensory axons (36). Nrn1 mRNA's transport into axons is increased during regeneration and its 5'UTR drives its localization (25).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…This family of proteins was shown to also play a role in axon growth, via the localization of their mRNA in axons and their local translation. For example, amphoterin (HMGB1) protein expression in axons increases following nerve injury, whereas the levels of amphoterin mRNA in the axons remain unaffected, suggesting that amphoterin is locally translated in axons in response to injury (95). Consistently, overexpression of axonally targeted amphoterin mRNA, but not cell body restricted mRNA increases axon outgrowth in cultured sensory neurons (95).…”
Section: Figmentioning
confidence: 99%
“…For example, amphoterin (HMGB1) protein expression in axons increases following nerve injury, whereas the levels of amphoterin mRNA in the axons remain unaffected, suggesting that amphoterin is locally translated in axons in response to injury (95). Consistently, overexpression of axonally targeted amphoterin mRNA, but not cell body restricted mRNA increases axon outgrowth in cultured sensory neurons (95). Another study suggests that the localization and local translation of transcripts coding for high mobility group nucleosome binding domain 5 (HMGN5) links neurite outgrowth to chromatin regulation in the nucleus (108).…”
Section: Figmentioning
confidence: 99%