“…In goldfish, the expression of mRNA for the NF ON-1 increased during optic nerve regeneration (Tesser et al, 1986;Glasgow et al, 1994). On the other hand, NF mRNA, protein synthesis, and transport are reduced in mammalian peripheral (Hoffman et al, 1985;Goldstein et al, 1988;Oblinger and Lasek, 1988) and central neurons (Mikucki and Oblinger, 1991;Tetzlaff et al, 1991;Hoffman et al, 1993;McKerracher et al, 1993a) after axotomy. The changes are reversed in peripheral neurons only after regenerating axons reach their targets (Hoffman et al, 1985;Hoffman and Cleveland, 1988;Muma et al, 1990;Wong and Oblinger, 1990b), and they persist if regeneration is prevented (Tetzlaff et al, 1988;Jiang et al, 1994).…”