Aza-BODIPY based polymeric nanoparticles for cancer cell imaging

Chansaenpak, Kantapat; Tanjindaprateep, Similan; Chaicharoenaudomrung, Nipha; Weeranantanapan, Oratai; Noisa, Parinya; Kamkaew, Anyanee

doi:10.1039/c8ra08145j

Cited by 24 publications

(9 citation statements)

References 41 publications

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Section: Resultsmentioning

confidence: 99%

“…The ability of P 188 to DSA with other hydrophobic molecules has recently been reported in the literature, for example, the anti-breast cancer celastrol with P 188 created NPs for drug delivery and other NIR-AZA uorophores for sensors and imaging applications. [23][24][25] Prior to a chemical biology study of its interactions with live cells it was necessary to demonstrate that transfer of 1 from within its nanoparticle form of NP1-P 188 to another entity could occur in water with a resulting functional uorescence response. To achieve this, solutions of NP1-P 188 were challenged with a polysorbate 20 (PS 20 ) as a competing surfactant.…”

Section: Introductionmentioning

confidence: 99%

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Exploiting directed self-assembly and disassembly for off-to-on fluorescence responsive live cell imaging

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploiting directed self-assembly and disassembly for off-to-on fluorescence responsive live cell imaging

et al. 2022

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“…The ability of P188 to DSA with other hydrophobic molecules has recently been reported in the literature, for example, the anti-breast cancer celastrol with P188 created NPs for drug delivery and other NIR-AZA fluorophores for sensors and imaging applications. 23,24,25 Prior to a chemical biology study of its interactions with live cells it was necessary to demonstrate that transfer of 1 from within its nanoparticle form of NP1-P188 to another entity could occur in water with a resulting functional fluorescence response. To achieve this, solutions of NP1-P188 were challenged with a polysorbate 20 (PS20) as a competing surfactant.…”

Section: Resultsmentioning

confidence: 99%

Exploiting Directed Self-Assembly and Disassembly for off-to-on Fluorescence Responsive Live Cell Imaging

Curtin

O’Shea

Garre

et al. 2022

Preprint

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A bio-responsive nanoparticle was formed by the directed self-assembly (DSA) of a hydrophobic NIR-fluorophore with poloxamer P188. Fluorophore emission was switched off when part of the nanoparticle, however upon stimulus induced nanoparticle dis-assembly the emission switched on. The emission quenching was shown to be due to fluorophore hydration and aggregation within the nanoparticle and the turn on response attributable to nanoparticle disassembly with embedding of the fluorophore within lipophilic environments. This was exploited for temporal and spatial live cell imaging with a measurable fluorescence response seen upon intracellular delivery of the fluorophore. The first dynamic response, seen within minutes, was from lipid droplets with other lipophilic regions such as the endoplasmic reticulum, nuclear membranes and secretory vacuoles imageable after hours. The high degree of fluorophore photostability facilitated continuous imaging for extended periods and the off to on switching facilitated the real-time observation of lipid droplet biogenesis as they emerged from the endoplasmic reticulum. With an in-depth understanding of the principles involved, further assembly controlling functional responses could be anticipated.

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“…The material obtained in this way was used to investigate the process of the uncontrolled release of encapsulated drugs in living cells. Another example is the encapsulation of luminophores in polymeric nanoparticles and applications in the field of cancer cell imaging [ 90 ].…”

Section: Methods For Immobilization Of Luminophores In a Polymeric Ma...mentioning

confidence: 99%

On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review

2022

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Polymers are widely used in many areas, but often their individual properties are not sufficient for use in certain applications. One of the solutions is the creation of polymer-based composites and nanocomposites. In such materials, in order to improve their properties, nanoscale particles (at least in one dimension) are dispersed in the polymer matrix. These properties include increased mechanical strength and durability, the ability to create a developed inner surface, adjustable thermal and electrical conductivity, and many others. The materials created can have a wide range of applications, such as biomimetic materials and technologies, smart materials, renewable energy sources, packaging, etc. This article reviews the usage of composites as a matrix for the optical sensors and biosensors. It highlights several methods that have been used to enhance performance and properties by optimizing the filler. It shows the main methods of combining indicator dyes with the material of the sensor matrix. Furthermore, the role of co-fillers or a hybrid filler in a polymer composite system is discussed, revealing the great potential and prospect of such matrixes in the field of fine properties tuning for advanced applications.

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Aza-BODIPY based polymeric nanoparticles for cancer cell imaging

Abstract: Encapsulation of hydrophobic aza-BODIPY dye could enhance its hydrophilicity yielding biocompatible nanoparticles which can be efficiently used in cancer cell imaging applications.

Cited by 24 publications

References 41 publications

Exploiting directed self-assembly and disassembly for off-to-on fluorescence responsive live cell imaging

Exploiting directed self-assembly and disassembly for off-to-on fluorescence responsive live cell imaging

Exploiting Directed Self-Assembly and Disassembly for off-to-on Fluorescence Responsive Live Cell Imaging

On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review

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