Azinphos-methyl causes in Planorbarius corneus toxic effects on reproduction, offspring survival and B-esterases depending on the exposure time

Agrelo, Macarena; Rivadeneira, Pamela Ruth; Cossi, Paula Fanny; Cacciatore, Luis Claudio; Kristoff, Gisela

doi:10.1016/j.cbpc.2018.12.002

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…Based on these considerations, in the present study, we analyzed the effects of the benzodiazepine delorazepam (DLZ) on locomotion in the freshwater gastropod Planorbarius corneus. This is a common model in ecotoxicological studies [27,28], as living in freshwater exposes it to many water pollutants. Three increasing concentrations were tested, considering the increase in BZD concentration in water in the last decade [29,30] and that the COVID-19 pandemic further contributed to reaching a peak [31,32].…”

Section: Introductionmentioning

confidence: 99%

Benzodiazepine Delorazepam Induces Locomotory Hyperactivity and Alterations in Pedal Mucus Texture in the Freshwater Gastropod Planorbarius corneus

Fogliano,

Carotenuto,

Agnisola

et al. 2023

IJMS

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Benzodiazepines, psychotropic drugs, are ubiquitous in the aquatic environment due to over-consumption and inefficient removal by sewage treatment plants. Bioaccumulation with consequent behavioral and physiological effects has been reported in many aquatic species. However, the responses are species-specific and still poorly understood. To improve the knowledge, we exposed the freshwater snail Planorbarius corneus to 1, 5, or 10 µg/L of delorazepam, the most widely consumed benzodiazepine in Italy. Conventional behavioral tests were used to assess the effects on locomotor and feeding behavior. Histological and biochemical analyses were also performed to detect possible changes in the structure and composition of the foot mucus and glands. The results show a paradoxical response with reduced feeding activity and locomotor hyperactivity. Pedal mucus was altered in texture but not in composition, becoming particularly rich in fibrous collagen-like material, and a significant change in the protein composition was highlighted in the foot. In conclusion, exposure to delorazepam induces disinhibited behavior in Planorbarius corneus, potentially increasing the risk of predation, and an increase in mucus protein production, which, together with reduced feeding activity, would severely compromise energy resources.

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Section: Introductionmentioning

confidence: 99%

Benzodiazepine Delorazepam Induces Locomotory Hyperactivity and Alterations in Pedal Mucus Texture in the Freshwater Gastropod Planorbarius corneus

Fogliano,

Carotenuto,

Agnisola

et al. 2023

IJMS

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“…Freshwater gastropods have been suggested as useful model organisms to evaluate the toxicity of chemicals compounds and environmental biomonitoring ( Tripathi and Singh, 2004 ; Rivadeneira et al, 2013 ; Tallarico et al, 2014 ; Otero and Kristoff, 2016 ; Agrelo et al, 2019 ; Herbert et al, 2021 ; Siqueira et al, 2021 ; Stein et al, 2021 ). Their slow mobility and difficulty to detoxify pollutants make them sensitive species for water contamination ( Gao et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…Their slow mobility and difficulty to detoxify pollutants make them sensitive species for water contamination ( Gao et al, 2017 ). Generally, embryos and juveniles are more sensitive to pollutants than adult gastropods ( Leung et al, 2007 ; Khangarot and Das, 2010 ; Attia et al, 2017 ; Agrelo et al, 2019 ), so toxicity data using the most vulnerable life stage would offer protection for all developmental stages in the environment ( Caixeta et al, 2022 ). However, not all gastropods are useful for reproduction assays due to their low rate of reproduction and slow development and growth, such as Chilina spp.…”

Section: Introductionmentioning

confidence: 99%

Aquatic Contamination in Lugano Lake (Lugano Lake Ecological Reserve, Buenos Aires, Argentina) Cause Negative Effects on the Reproduction and Juvenile Survival of the Native Gastropod Biomphalaria straminea

et al. 2022

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Lugano Lake is located in an Ecological Reserve of Buenos Aires City. Biomonitoring of its water quality is essential due to its importance as a place for recreation and protection of native species. Biomphalaria straminea is a native hermaphrodite aquatic gastropod that inhabits different freshwater bodies of Argentina and was recently selected as a potential bioindicator. We propose this study as a first approach to assessing specific organisms’ use in biomonitoring of urban wild reserves, and the usefulness of reproduction assays. B. straminea survival, behavior, reproduction success and offspring survival after the exposure to water samples from Lugano Lake (L1, L2, and L3) were evaluated. Temperature, pH, conductivity and dissolved oxygen were registered in situ. Samples were transported to the laboratory and chemical analysis and bioassays were performed using 20 snails per site. A control group with tap water was added. Egg masses were separated, exposed individually and observed daily using a stereoscopic microscope. After hatching, juveniles were placed in tap water and offspring survival was registered at the first, second, third and fourth months after the beginning of the assay. High levels of conductivity, turbidity and nutrients were obtained. Ammonium and nitrite were higher than the guideline level for the protection of aquatic life. During the bioassay 20% of the snails (L2 and L3) showed abnormally protruding of the head-food region. The number of eggs and embryonated eggs per mass did not differ between treatments. Egg masses exposed to water samples from the lake presented overlapping and abnormal eggs and arrested embryos. Besides, low % of hatching (L1: 33%, L2: 42%, and L3: 16%) and juvenile survival after the first (L1:14%; L2:78%) and second month (L1: 60%) were noted. In the control group, 85% of hatching and 100%–90% of survival were observed. Our results suggests the presence of pollutant in the lake. B. straminea seems to be a sensitive local species. Biomphalaria spp. reproduction assays can provide a valuable endpoint for toxicity and risk assessments and a usefulness tool for biomonitoring water quality.

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Differential Responses of Biochemical and Behavioral Parameters in the Native Gastropod Chilina gibbosa Exposed Subchronically to Environmental Concentrations of Two Insecticides Used in Argentina

Boburg

Herbert

Cossi

et al. 2019

Pollution of Water Bodies in Latin America

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Azinphos-methyl causes in Planorbarius corneus toxic effects on reproduction, offspring survival and B-esterases depending on the exposure time

Cited by 5 publications

References 55 publications

Benzodiazepine Delorazepam Induces Locomotory Hyperactivity and Alterations in Pedal Mucus Texture in the Freshwater Gastropod Planorbarius corneus

Benzodiazepine Delorazepam Induces Locomotory Hyperactivity and Alterations in Pedal Mucus Texture in the Freshwater Gastropod Planorbarius corneus

Aquatic Contamination in Lugano Lake (Lugano Lake Ecological Reserve, Buenos Aires, Argentina) Cause Negative Effects on the Reproduction and Juvenile Survival of the Native Gastropod Biomphalaria straminea

Differential Responses of Biochemical and Behavioral Parameters in the Native Gastropod Chilina gibbosa Exposed Subchronically to Environmental Concentrations of Two Insecticides Used in Argentina

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