Azithromycin as prophylaxis for the prevention of postoperative infection in impacted mandibular third-molar surgery

Ishihama, Kohji; Kimura, Tetsuo; Yasui, Yukihiko; Komaki, Masashi; Ota, Yuji

doi:10.1007/s10156-005-0419-6

Cited by 23 publications

(18 citation statements)

References 18 publications

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“…This requires that the antibiotic be given approximately 1 h before the procedure [1,2]. The result obtained in our study is comparable to a similar study carried out by Ishihama et al [10] where Azithromycin was used as a prophylactic antibiotic and the incidence of SSI was 2.2 %.…”

Section: Discussionsupporting

confidence: 81%

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Efficacy of Single Dose Azithromycin as Prophylactic Antibiotic in Surgical Removal of Mandibular Third Molars: A Clinical Study

Sane

Gadre

Chandan

et al. 2013

J. Maxillofac. Oral Surg.

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Section: Discussionsupporting

confidence: 81%

“…Giving post-operative antibiotic without pre-operative administration, in minor oral surgery such as surgical SRMTM is questionable. This practice does not achieve the first goal of antibiotic prophylaxis which is to achieve adequate tissue levels and MIC [10].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Single Dose Azithromycin as Prophylactic Antibiotic in Surgical Removal of Mandibular Third Molars: A Clinical Study

Sane

Gadre

Chandan

et al. 2013

J. Maxillofac. Oral Surg.

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“…Blakey et al 15 reported that 25% of patients with impacted mandibular third molar had asymptomatic periodontitis. The subsequent postoperative infections can cause undesirable outcomes, such as deep space infections, although the incidence is low, at 0.8% 16 . Although there is evidence that postoperative antibiotics can lower the incidence of postoperative complications 12 , 17 , there is equally convincing evidence to the contrary 10 , 17 , 18 , 19 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of amoxicillin-clavulanic acid with metronidazole to azithromycin with metronidazole after surgical removal of impacted lower third molar to prevent infection

Sayd

Vyloppilli

kumar³

et al. 2018

J Korean Assoc Oral Maxillofac Surg

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ObjectivesThe goal of the study was to investigate the clinical effects of amoxicillin-clavulanic acid (500+125 mg) with metronidazole 400 mg administered three times daily (Group I) versus azithromycin 500 mg administered once daily and with metronidazole 400 mg three times daily (Group II) for the prevention of postoperative infection following mandibular third molar surgical removal.Materials and MethodsThe study design was a single-center prospective study. Patients who reported to the Department of Oral and Maxillofacial Surgery between February 2015 and January 2017 for removal of mandibular third molar were screened, and 108 patients were chosen. One surgeon carried out all procedures. Patients were prescribed antibiotics until the two groups contained a similar number of cases.ResultsOur data showed that Group II had fewer incidences of surgical site infection, but with no statistical significance.ConclusionAlthough both treatments are used routinely after removal of the mandibular third molar, neither is significantly better than the other.

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“…15,16 Study on the infection rates with Azithromycin has shown to be as low as 0%. 17 These all point out that prophylactic antimicrobial agents indeed decrease the infection rate.…”

Section: Discussionmentioning

confidence: 97%

“…Very few studies are present which have compared Amoxicillin with other antimicrobials in dentistry. [15][16][17] The present study is aimed to compare the efficacy of Azithromycin to Amoxicillin in healthy subjects undergoing surgical extraction of impacted mandibular third molars.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on Efficacy of Amoxicillin and Azithromycin in Prevention of Postoperative Sequelae Following Third Molar Surgery

Gurung¹,

Bimb²,

Shrestha³

2019

Nep. Med. Coll. J.

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Amoxicillin is the commonly prescribed antimicrobial for prevention of post-operative complications following surgical extraction of mandibular third molar. However recently, the use of macrolideantibiotics had been encouraged in dentistry. The aim of this study was to compare the efficacy of Amoxicillin and Azithromycin in preventing post-operative sequelae following third molar surgery. An open- labeled randomized controlled study was carried out in Department of Oraland Maxillofacial surgery, college of Dental Sciences and Hospital, Nepal Medical College (CODSHNMC), Attarkhel, Kathmandu, Nepal from May 2018 to June 2019. One hundred and twenty patients undergoing surgical extraction of impacted mandibular third molar were randomized by lottery method into two groups: Group A received Amoxicillin and Group B received Azithromycin. Both the groups were assessed postoperatively on 1st, 3rd and 7th days for post-operative complications- pain, swelling, trismus and pus discharge. The present study revealed no significant differences between the efficacy of Amoxicillin and Azithromycin in preventing postoperative sequelae following surgical extraction of impacted third molar. Amoxicillin and Azithromycin were therefore found to be equally effective. Thus, Azithromycin can be used as an alternative drug to Amoxicillin in case of resistance and intolerance to Amoxicillin.

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Azithromycin as prophylaxis for the prevention of postoperative infection in impacted mandibular third-molar surgery

Cited by 23 publications

References 18 publications

Efficacy of Single Dose Azithromycin as Prophylactic Antibiotic in Surgical Removal of Mandibular Third Molars: A Clinical Study

Efficacy of Single Dose Azithromycin as Prophylactic Antibiotic in Surgical Removal of Mandibular Third Molars: A Clinical Study

Comparison of the efficacy of amoxicillin-clavulanic acid with metronidazole to azithromycin with metronidazole after surgical removal of impacted lower third molar to prevent infection

A Comparative Study on Efficacy of Amoxicillin and Azithromycin in Prevention of Postoperative Sequelae Following Third Molar Surgery

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