Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy

Zhou, Ying; Maiti, Mrinmoy; Sharma, Amit; Won, Miae; Yu, Le; Miao, Lan; Shin, Jin Woo; Podder, Arup; Bobba, Kondapa Naidu; Han, Jiyou; Bhuniya, Sankarprasad; Kim, Jong Seung

doi:10.1016/j.jconrel.2018.08.036

Cited by 67 publications

(52 citation statements)

References 43 publications

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“…Here, the new designed probe has a signicant difference in chemical structure, as shown in Scheme 1, to most of the reported probes, where the functional group was connected to the electron-donating end of the uorophore molecule. 9,16,19,23 Here, the azo group of the probe AZO-Cy connected to the electron-withdrawing end which is a rst report.…”

Section: Spectrum Of Probe Azo-cy Towards Cytochrome P450 Reductasementioning

confidence: 95%

“…Several studies have proved that azo aromatic compounds are good substrates for cytochrome P450 reductase. 18,[20][21][22][23] Some uorescent probes showed good performance under different oxygen partial pressures which meant the azo group was very effective to detect hypoxia. Based on our previous work, 19 herein, we report a farred emitting probe AZO-Cy containing an azo moiety which can be metabolized by cytochrome P450 reductase in hypoxic conditions, the probe displayed a strong uorescence OFF-ON response at 610 nm in PBS buffer and in hypoxia imaging in tumor cells.…”

Section: Introductionmentioning

confidence: 99%

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Novel designed azo substituted semi-cyanine fluorescent probe for cytochrome P450 reductase detection and hypoxia imaging in cancer cells

et al. 2019

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Section: Spectrum Of Probe Azo-cy Towards Cytochrome P450 Reductasementioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Novel designed azo substituted semi-cyanine fluorescent probe for cytochrome P450 reductase detection and hypoxia imaging in cancer cells

et al. 2019

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“…Azo bond, nitroaromatic heterocyclics (nitrobenzyl, nitrofuran, etc. ), trimethyl-locked quinone systems and indolequinone can all be dubbed as hypoxia-sensitive linkers [ [55] , [56] , [57] ]. The Kim group [ 58 ] developed a hypoxia-response N , N -bis(2-chloroethyl)-1,4-benzene-diamine prodrug 9 ( Fig.…”

Section: Cleavable Conjugatesmentioning

confidence: 99%

Recent advances in construction of small molecule-based fluorophore-drug conjugates

Lang

Yuan

Zhu

et al. 2020

Journal of Pharmaceutical Analysis

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As a powerful tool to advance drug discovery, molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels. When compared with other detection methods, fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’ transport, with multi-color capacity, high specificity and good sensitivity. The conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution, both in vitro and in vivo. In this short review, we discuss recent developments of small molecule-based fluorophore-drug conjugates, including non-cleavable and cleavable ones, that are capable of visualizing drug delivery.

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“…A micelle delivery system based on azoreductase responsiveness is reported to break in the presence of the azoreductase enzyme to deliver the loaded drug to the colon area [46]. Recently, by the use of an azo derivative an antineoplastic drug was reported to have dual function of therapeutic and diagnostic (theranostic agent) with a possibility to enhance the cancer therapy [47].…”

Section: Azoreductase-responsive Medication Conveyancementioning

confidence: 99%

Polymers, responsiveness and cancer therapy

Pethe

Yadav

2019

Artificial Cells, Nanomedicine, and Biotechnology

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A single outcome in a biological procedure at the time of cancer therapy is due to multiple changes happening simultaneously. Hence to mimic such complex biological processes, an understanding of stimuli responsiveness is needed to sense specific changes and respond in a predictable manner. Such responses due to polymers may take place either simultaneously at the site or in a sequential manner from preparation to transporting pathways to cellular compartments. The present review comprehends the stimuli-responsive polymers and multi-responsiveness with respect to cancer therapy. It focuses on the exploitation of different stimuli like temperature, pH and enzymes responsiveness in a multi-stimuli setting. Nanogels and micelles being two of the most commonly used responsive polymeric carriers have also been discussed. The role of multiple stimuli delivery system is significant due to multiple changes happening in the near surroundings of cancer cells. These responsive materials are able to mimic some biological processes and recognize at the molecular level itself to manipulate development of custom-designed molecules for targeting cancer cells.

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Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy

Cited by 67 publications

References 43 publications

Novel designed azo substituted semi-cyanine fluorescent probe for cytochrome P450 reductase detection and hypoxia imaging in cancer cells

Novel designed azo substituted semi-cyanine fluorescent probe for cytochrome P450 reductase detection and hypoxia imaging in cancer cells

Recent advances in construction of small molecule-based fluorophore-drug conjugates

Polymers, responsiveness and cancer therapy

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