Abstract:Amyloid-beta (Abeta) oligomers consist of fibrillar and non-fibrillar soluble assemblies of the Abeta peptide. Tg2576 human amyloid precursor protein (APP)-expressing transgenic mice modeling Alzheimer disease produce Abeta*56, a non-fibrillar Abeta assembly that has been shown by several groups to relate more closely to memory deficits than plaques. Previous studies did not decipher specific forms of Abeta present in Abeta*56. Here, we confirm and extend the biochemical characterization of Abeta*56. We used a… Show more
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