B and T Cell Markers of Bone Marrow and Peripheral Blood Lymphoid Cells in Patients with Paraproteinaemia

Abstract

Studies have been carried out on B and T cells in bone marrow and peripheral blood from patients with paraproteinaemia. The peripheral blood of patients with multiple myeloma showed a significant increase of B cells, mainly lymphoid cells bearing immunoglobulins corresponding to the paraproteins, while in patients with benign monoclonal gammopathy only a slight increase of B cells and a moderate decrease of T cells have been found. As to the bone marrow, the B cell population was significantly raised in patients with multiple myeloma, but it remained unchanged in patients with benign monoclonal gammopathy. Our findings may offer a new possibility to distinguish between these two diseases and provide further data to their pathogenesis.

Decrease of Fcγ and C3b receptor‐bearing granulocytes and of T lymphocytes in myelomatosis

“…The patients were mostly older than the controls, but we have not found age to be a significant factor in receptor studies. Previous investigations of granulocyte function in patients with myelomatosis have demonstrated impairment due to serum or plasma factors (3,5 ) . Hopen et al (4) found myelomatosis serum to decrease granulocyte adhesion and migration; this effect could not, however, be correlated to the decreased phagocytosis by myelomatosis granulocytes, as measured by chemiluminescence.…”