B‐cell repertoire and clonal analysis in unaffected first degree relatives in familial chronic lymphocytic leukaemia kindred

Abbasi, Fatima; Longo, Nancy S.; Lipsky, Peter E.; Raveché, Elizabeth; Schleinitz, Thérèse Aurran; Stetler‐Stevenson, Maryalice; Caporaso, Neil E.; Marti, Gerald E.

doi:10.1111/j.1365-2141.2007.06857.x

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…Despite the variability in prevalence estimates, it is obvious that MBL is more common among the elderly and first-degree relatives of CLL patients. The prevalence of MBL in our cohort seems to confirm the previously reported data [ 1 , 2 , 3 , 7 , 10 , 21 ]. As intermarriage is frequently encountered in certain regions of Anatolia, we did analyse the possible impact of intermarriage on MBL prevalence in CLL families.…”

Section: Discussionsupporting

confidence: 93%

“…In previous reports, the presence of familial clustering in CLL has been widely confirmed. Approximately 12% of patients with CLL report a family history of a lymphoproliferative disease, while 6-9% have a relative who has also CLL [ 2 , 3 , 4 , 10 ]. Based on epidemiological studies, first-degree relatives of CLL patients have 3-8 times greater risk for the development of CLL [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…MBL is more common in CLL families. The prevalence of MBL among first-degree relatives of CLL patients ranges between 12% and 18% [ 1 , 10 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Monoclonal B Lymphocytosis in First- Degree Relatives of Chronic Lymphocytic Leukemia Patients in Turkey

Demirci

Yeğin²,

Kurşunoğlu³

et al. 2015

Tjh

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Objective:Monoclonal B lymphocytosis (MBL) is considered to be a precursor state for chronic lymphocytic leukemia (CLL). This study was planned to evaluate the MBL prevalence in first-degree relatives of CLL patients in Turkey, which is considered to be an ethnic and geographic bridge between the Eastern and Western worlds. Materials and Methods:A total of 136 volunteers [median age: 40 (17-77) years; male/female: 60/76] from 61 families were included. Flow cytometry analysis by 4-colour staining was used for MBL diagnosis. Results:MBL was demonstrated in 17 cases (12.5%). A total of 14 cases (10.3%) were classified as CLL-like MBL, while 3 (2.2%) exhibited a non-CLL-like phenotype. The prevalence of MBL was 12.72% in subjects aged less than 40 years, 12.28% in subjects between 40 and 60 years, and 40% in subjects over 60 years, without statistical significance (p>0.05). A total of 115 cases were evaluated for intermarriage, which was observed in 19 cases (16.5%). The prevalence of MBL did not differ based on intermarriage status (p>0.05).Conclusion:The current report is the first MBL prevalence study in a Eurasian population that demonstrates a similar distribution pattern of MBL in Anatolian CLL kindreds. Further efforts should be made to refine our understanding of the natural history and clinical outcomes of MBL.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Prevalence of Monoclonal B Lymphocytosis in First- Degree Relatives of Chronic Lymphocytic Leukemia Patients in Turkey

Demirci

Yeğin²,

Kurşunoğlu³

et al. 2015

Tjh

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“…A total of 200,000 events per tube were acquired. Sequential gating strategy was used as previously described [15,25].…”

Section: Methodsmentioning

confidence: 99%

“…However, with more sensitive methods, CLLlike cells were identified in more than 10% of adults aged 40 years or more [18]. Monoclonal B-cell lymphocytosis is considered as a marker of inherited predisposition to CLL, as it was demonstrated in 13-18% of first-degree relatives of CLL patients in high risk families [2][3][4][7][8][9][10][11]13,14,16,[19][20][21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Monoclonal B-cell lymphocytosis in blood donors in Turkey

et al. 2017

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Monoclonal B Cell Lymphocytosis—What Does It Really Mean?

Rawstron

2013

Curr Hematol Malig Rep

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Monoclonal B cell Lymphocytosis (MBL) or similar terms have been used for decades to describe the presence of light-chain restricted B lymphocytes with uncertain clinical significance, usually having a phenotype consistent with chronic lymphocytic leukemia (CLL). As diagnostic technology improved, ever smaller monoclonal B cell populations were identifiable in the population, and approximately half of people over 90 years old have a minimal (<1 cell/μL) circulating CLL-like B cell population. These minimal CLL-like B cell populations share some molecular characteristics with CLL, but have no clinical significance. In contrast, CLL-like MBL cases detected through hospital investigations are biologically indistinguishable from early stage CLL, but the neoplastic B cell levels are usually stable over time and the risk of progressive disease requiring treatment is much lower than for early stage CLL. However, there is usually partial or complete depletion of normal B cells, with an increased relative risk of severe infection, comparable to early stage CLL, which may impair overall survival.

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B‐cell repertoire and clonal analysis in unaffected first degree relatives in familial chronic lymphocytic leukaemia kindred

Cited by 5 publications

References 12 publications

Prevalence of Monoclonal B Lymphocytosis in First- Degree Relatives of Chronic Lymphocytic Leukemia Patients in Turkey

Prevalence of Monoclonal B Lymphocytosis in First- Degree Relatives of Chronic Lymphocytic Leukemia Patients in Turkey

Monoclonal B-cell lymphocytosis in blood donors in Turkey

Monoclonal B Cell Lymphocytosis—What Does It Really Mean?

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