2010
DOI: 10.1016/j.humimm.2010.01.019
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B-cell–T-cell activation and interaction in common variable immunodeficiency

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Cited by 25 publications
(17 citation statements)
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References 31 publications
(33 reference statements)
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“…Our study also highlights the importance of considering T-cell activation [12,13] in PHID (clusters 3 and 4 with increased T-cell activation with the highest percentage of complications, comprising mainly CVID patients and the three patients with Good’s syndrome identified in our cohort as PHID types). Moreover, the occurrence of two complications considered in addition to those defined by H Chapel et al [6] (ie: splenomegaly and granulomatous disease) were found with the highest frequency in the clusters 3 and 4 with increased T-cell activation, suggesting that the HLA-DR + activation marker could help to discriminate them.…”
Section: Discussionsupporting
confidence: 55%
See 1 more Smart Citation
“…Our study also highlights the importance of considering T-cell activation [12,13] in PHID (clusters 3 and 4 with increased T-cell activation with the highest percentage of complications, comprising mainly CVID patients and the three patients with Good’s syndrome identified in our cohort as PHID types). Moreover, the occurrence of two complications considered in addition to those defined by H Chapel et al [6] (ie: splenomegaly and granulomatous disease) were found with the highest frequency in the clusters 3 and 4 with increased T-cell activation, suggesting that the HLA-DR + activation marker could help to discriminate them.…”
Section: Discussionsupporting
confidence: 55%
“…Giovanetti et al [11] performed an in-depth analysis of the T-cell compartment in CVID patients and demonstrated multiple T-cell abnormalities. T-cell activation is an important process underlined [12,13] that need to be explored, together with T-cell regulation [14,15]. Indeed, gammadelta T cells [16] and innate cell abnormalities reported in Natural Killer cells (NK) [17] or myeloid dendritic (mDC) and plasmacytoid dendritic cells (pDC) [18] may further contribute to the heterogeneous presentation of CVID.…”
Section: Introductionmentioning
confidence: 99%
“…1b). As expected [11][12][13]17 a-o-dex induced B-cell activation, leading to significant increases in B-cell CD86 and CD25 expression (see Supporting information, Fig. S1).…”
Section: Igd Stimulation Of B Cells Inhibits T Cell Activation and Prsupporting
confidence: 80%
“…However, an alteration in the frequency and function of T cells has also been demonstrated in patients with CVID [12][13][14]. The influence of these defects on the interaction between T and B cells could explain not only defective antibody production, but also the development of other complications, including recurrent bacterial and viral infections, gastrointestinal disease, lymphoma, autoimmunity, inflammation, and early-onset bronchiectasis in CVID patients [15][16][17]. In this review, we describe phenotypic and functional T-cell defects in patients with CVID and review the literature on the effects of intravenous immunoglobulin (IVIG) infusion on T-cell components in CVID.…”
Section: Common Variable Immunodeficiency (Cvid) Is the Most Common Cmentioning
confidence: 99%