B Cells and Transplantation: An Educational Resource

Small, Trudy N.; Robinson, William H.; Miklos, David B.

doi:10.1016/j.bbmt.2008.10.016

Cited by 22 publications

(16 citation statements)

References 111 publications

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“…In addition, somatic hypermutation seems to be diminished even in the presence of normal donor CD4 + T cell numbers, implying an environmental defect (26, 34). Normal levels of serum IgM are usually measurable 3–6 months after HSCT (35, 36), followed by normalization of serum IgG1/IgG3, IgG2/IgG4, and IgA similar to that observed during normal development in the first years of life (37). However, in some patients, long-term antibody class deficiencies have been reported (38).…”

Section: Adaptive Immunitymentioning

confidence: 86%

“…However, in some patients, long-term antibody class deficiencies have been reported (38). The immunoglobuline heavy chain (IgH) repertoire is often characterized by delayed class switching and oligoclonal dominance with specific rearrangements dominating at different time points in these patients (36, 39). Measurement of B lymphocyte repertoire diversity by analysis of IgH complementarity determining region 3 (CDR3) revealed limited variation of IgH CDR3 repertoire in CD19 + CD27 + memory B lymphocytes compared to CD19 + CD21 high CD27 − naive B cells at 3 and 6 months after allogeneic HSCT.…”

Section: Adaptive Immunitymentioning

confidence: 99%

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Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2016

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The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical grafts were associated with prolonged immunodeficiency due to delayed immune reconstitution, raising the need for better understanding and enhancing the process of immune reconstitution and finding strategies to further optimize these transplant procedures. Immune reconstitution post-HSCT occurs in several phases, innate immunity being the first to regain function. The slow T cell reconstitution is regarded as primarily responsible for deleterious infections with latent viruses or fungi, occurrence of graft-versus-host disease, and relapse. Here we aim to summarize the major steps of the adaptive immune reconstitution and will discuss the importance of immune balance in patients after HSCT.

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Section: Adaptive Immunitymentioning

confidence: 86%

Section: Adaptive Immunitymentioning

confidence: 99%

Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2016

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“…Although we compared the specificity of the HLA antibodies that emerged in patients with those found in their donors, it may be argued that this is not a formal proof of donor derivation. Theoretically, donor-derived antibodies may be distinguished from recipient-derived antibodies by allotype 30 after isolation of HLA antibodies. However, this is a technically difficult task because of the low titers of specific antibodies.…”

Section: Discussionmentioning

confidence: 99%

Donor-derived HLA antibody production in patients undergoing SCT from HLA antibody-positive donors

Taniguchi

Yoshihara

Maruya³

et al. 2012

Bone Marrow Transplant

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“…B-cell subsets include CD27 Ϫ IgD ϩ naïve B cells, CD27 ϩ IgD ϩ "able to class switch" memory cells, and CD27 ϩ IgD Ϫ "isotype switched" memory cells. 24 NK populations include NK and TCR-V-alpha-24 ϩ NKT cells, and dendritic cells include myeloid DCs (CD123 low/ϩ CD11c ϩ ) and plasmacytoid DCs (CD123 bright CD11c neg ). Flow cytometry can also identify antigen-specific responses using either intracellular cytokine detection or tetramers.…”

Section: Monitoring Of Post-transplant Immune Reconstitutionmentioning

confidence: 99%