B cells in classical Hodgkin lymphoma are important actors rather than bystanders in the local immune reaction

Tudor, Christiane S.; Distel, Luitpold; Eckhardt, Jenny; Hartmann, Arndt; Niedobitek, Gerald; Buettner, Maike

doi:10.1016/j.humpath.2013.06.006

Cited by 26 publications

(37 citation statements)

References 33 publications

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“…IL-6 has been shown to be produced by HRS cells in some cases of cHL, and this may explain the presence of variable amounts of plasma cells [ 28 ]. B cells that express CD20, CD21, IgM, and bcl-6 can be found in cHL [ 29 ]. It is possible that these cells are remnants of the original lymph node B cell areas.…”

Section: Eosinophils Plasma Cells Mast Cells and B Cellsmentioning

confidence: 99%

Microenvironment, Crosstalk, and Immune Escape Mechanisms

et al. 2014

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Section: Eosinophils Plasma Cells Mast Cells and B Cellsmentioning

confidence: 99%

Microenvironment, Crosstalk, and Immune Escape Mechanisms

et al. 2014

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“…There is increasing evidence that different tumour microenvironmental compositions have prognostic relevance in cHL (Vardhana & Younes, ; Hollander et al , ). Although T cells have been explored, B cells are less well studied (Tudor et al , ; Aldinucci et al , ; Vardhana & Younes, ; Hollander et al , ). In studies on B cells in the tumour microenvironment of cHL (Greaves et al , ; Tudor et al , ), high numbers of CD20+ B cells and naïve immunoglobulin M (IgM)‐producing plasma cells are associated with better survival.…”

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confidence: 99%

“…Although T cells have been explored, B cells are less well studied (Tudor et al , ; Aldinucci et al , ; Vardhana & Younes, ; Hollander et al , ). In studies on B cells in the tumour microenvironment of cHL (Greaves et al , ; Tudor et al , ), high numbers of CD20+ B cells and naïve immunoglobulin M (IgM)‐producing plasma cells are associated with better survival. However, the CD20 marker is not expressed by terminally differentiated plasma cells (DiLillo et al , ; Nelson, ).…”

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confidence: 99%

“…Therefore, these B cells constitute a different phenotype to plasma cells that express CD138 (also termed Syndecan‐1, SDC1), which is a transmembrane protein acquired post‐GC (DiLillo et al , ; Nelson, ). Post‐GC plasma cells are important prognostic actors in diverse malignancies (Yip et al , ; Zhang et al , ; Bodoor et al , ; Mohammed et al , ; Berntsson et al , ; Lundgren et al , ), but there is a lack of clinicopathological studies examining late differentiated plasma cells in cHL (Tudor et al , ; Aldinucci et al , ; Vardhana & Younes, ; Hollander et al , ).…”

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High tumour plasma cell infiltration reflects an important microenvironmental component in classic Hodgkin lymphoma linked to presence of B‐symptoms

et al. 2018

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Summary Plasma cells are important prognostic actors in different malignancies. The tumour microenvironmental composition in classic Hodgkin lymphoma (cHL) is a major prognostic key element; however, clinicopathological studies regarding plasma cells in cHL are lacking. The aim of this study was to investigate CD138+ (also termed SDC1+) plasma cell and IgG4 producing (IgG4+) plasma cells infiltration in the microenvironment of cHL. Immunohistochemistry with anti‐CD138 and IgG4 antibodies was performed on diagnostic tumour biopsies from 124 patients with cHL, on tissue micro array (TMA). In 120 cases, CD138+ plasma cell‐infiltration was associated with the presence of B‐symptoms (P = 0·028) and advanced stage, IIB‐IVB (P = 0·009). In multivariate analysis, CD138+ plasma cells correlated with eosinophil infiltration (P = 0·013). The subgroup of IgG4+ plasma cells was analysed in 122 cases and only correlated to CD138+ plasma cells (P = 0·004). Patients with high proportion of tumour infiltrating CD138+ plasma cells (defined as ≥10%), had a more inferior event‐free survival (P = 0·007) and overall survival (P = 0·004) than patients with a low proportion of infiltrating CD138+ plasma cells (<10%), although significance was not maintained in multivariate analysis. In summary, a high proportion of tumour‐associated plasma cells in cHL reflect an important component in the microenvironment of cHL.

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“…44 With regard to lymphocyte subsets in the tumor microenvironment, increased numbers of non-follicular B cells are associated with favorable survival, indicating that they likely play an important role in the immunological control of cHL. 39,45,46 Somewhat counter-intuitively, increased numbers of FOXP3 + T regs have been associated with superior progression-free and overall survival. 39,47,48 while increased numbers of granzyme B + cytotoxic T cells have the opposite effect on survival.…”

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confidence: 99%