B-Complex Vitamins in Liver Disease of the Alcoholic

Leevy, Carroll M.; Baker, Herman; tenHove, Willem; Frank, Oscar; Cherrick, Gilbert R.

doi:10.1093/ajcn/16.4.339

Cited by 201 publications

(37 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An early study of a city hospital population identified 18 chronic alcoholics, some with liver disorders, and noted vitamin deficiencies and general health problems in this group of indigent patients [13]. Other studies of indigent patients have revealed a folate deficiency rate of 80% with a related anemia in 44% [7] and a 40% rate of hypovitaminemia regarding the Β vitamins [14]. Relevant studies are summarized in Table 2.…”

Section: Discussionmentioning

confidence: 99%

Nutritional status of alcoholics of different socioeconomic class.

Goldsmith¹,

Iber²,

Miller³

1983

Journal of the American College of Nutrition

View full text Add to dashboard Cite

Most studies concerning the nutritional status of alcoholics have focused on the indigent alcoholic but programs now increasingly consider the working patient. The role of socioeconomic status in determining nutritional status of the alcoholic is further clarified in this study. One hundred patients from an alcoholic population were studied, 50 with low socioeconomic status and 50 with middle or higher socioeconomic status. The nutritional status of these two different socioeconomic groups was examined and compared. The middle-income alcoholic had significantly higher values in weight to height index (P less than .02), the triceps skinfold (P less than .01), the midarm muscle circumference (P less than .05), hematocrit (P less than .01), and epilation force (P less than .001) than the lower-income alcoholic group. Hair-pulling tension was compared in both groups as an index of protein malnutrition. There was a highly significant difference in the two groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Nutritional status of alcoholics of different socioeconomic class.

Goldsmith¹,

Iber²,

Miller³

1983

Journal of the American College of Nutrition

View full text Add to dashboard Cite

show abstract

“…Vitamin B6 deficiency occurs in about two-thirds of chronic alcoholics with liver disease with overall significantly lower levels than in normal subjects [21,47] . One of the principal clinical manifestations of vitamin B6 deficiency in alcoholism is sideroblastic anemia as was found by bone marrow examination in 23 % of a sequential series of hospitalized anemic chronic alcoholic patients [48] .…”

Section: Effects Of Alcoholism On Vitamin B6 and B12 Statusmentioning

confidence: 99%

B-Vitamin dependent methionine metabolism and alcoholic liver disease

Halsted

2013

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

Convincing evidence links aberrant B-vitamin dependent hepatic methionine metabolism to the pathogenesis of alcoholic liver disease (ALD). This review focuses on the essential roles of folate and vitamins B6 and B12 in hepatic methionine metabolism, the causes of their deficiencies among chronic alcoholic persons, and how their deficiencies together with chronic alcohol exposure impact on aberrant methionine metabolism in the pathogenesis of ALD. Folate is the dietary transmethylation donor for the production of S-adenosylmethionine (SAM), which is the substrate for all methyltransferases that regulate gene expressions in pathways of liver injury, as well as a regulator of the transsulfuration pathway that is essential for production of glutathione (GSH), the principal antioxidant for defense against oxidative liver injury. Vitamin B12 regulates transmethylation reactions for SAM production and vitamin B6 regulates transsulfuration reactions for GSH production. Folate deficiency accelerates the experimental development of ALD in ethanol-fed animals while reducing liver SAM levels with resultant abnormal gene expression and decreased production of antioxidant GSH. Through its effects on folate metabolism, reduced SAM also impairs nucleotide balance with resultant increased DNA strand breaks, oxidation, hepatocellular apoptosis, and risk of carcinogenesis. The review encompasses referenced studies on mechanisms for perturbations of methionine metabolism in ALD, evidence for altered gene expressions and their epigenetic regulation in the pathogenesis of ALD, and clinical studies on potential prevention and treatment of ALD by correction of methionine metabolism with SAM.

show abstract

“…LEEVY et al (2) reported that serum and tissue vitamin levels were frequently reduced in alcoholic patients with fatty livers . Decreased liver levels of pantothenic acid in conjunction with increased serum …”

Section: Discussionmentioning

confidence: 99%