B Lymphocytes in Untreated Patients with Malignant Lymphoma and Hodgkin's Disease

Gajl‐Peczalska, Kazimiera J.; Bloomfield, Clara D.; Good, Robert A.

doi:10.1172/jci107505

Cited by 64 publications

(13 citation statements)

References 36 publications

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“…1976 The finding that peripheral blood lymphocytes from patients with untreated Hodgkin's disease react normally when used as a source of responder cells in the MLR test (Fig. 4) is consistent with other reports in the literature (44,45). After total lymphoid irradiation, there was a marked reduction of the ability of the peripheral blood lymphocytes to respond in the MLR reaction (Fig.…”

Section: Reversal Of Cell Surface Abnormalities Of T Lymphocytes Insupporting

confidence: 87%

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Fuks¹,

Strober²,

Bobrove³

et al. 1976

J. Clin. Invest.

269

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Section: Reversal Of Cell Surface Abnormalities Of T Lymphocytes Insupporting

confidence: 87%

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Fuks¹,

Strober²,

Bobrove³

et al. 1976

J. Clin. Invest.

269

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“…Our normal values obtained by the examination of B and T cell mar kers from PB are about the same as or somewhat lower than those gener ally mentioned in the literature [3,4,9,15,16,20,22,27], Relatively fewer data are available about B and T cell markers from BM [1,5,14,17,19,20,23,25]. It has been firmly established that mature T lympho cytes do exist within the BM, too.…”

Section: Discussionsupporting

confidence: 61%

B and T Cell Markers of Bone Marrow and Peripheral Blood Lymphoid Cells in Patients with Paraproteinaemia

et al. 1977

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Studies have been carried out on B and T cells in bone marrow and peripheral blood from patients with paraproteinaemia. The peripheral blood of patients with multiple myeloma showed a significant increase of B cells, mainly lymphoid cells bearing immunoglobulins corresponding to the paraproteins, while in patients with benign monoclonal gammopathy only a slight increase of B cells and a moderate decrease of T cells have been found. As to the bone marrow, the B cell population was significantly raised in patients with multiple myeloma, but it remained unchanged in patients with benign monoclonal gammopathy. Our findings may offer a new possibility to distinguish between these two diseases and provide further data to their pathogenesis.

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“…It has long been known that a few aty pical lymphocytes may be present in the peripheral blood (PB) of patients with non-leukemic non-Hodgkin lymphomas (NHL) [1], especially in cases with bone marrow involvement and certain histo pathologic types [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte Populations and T Cell Subpopulations in Blood of Patients with Non-Hodgkin Lymphomas

et al. 1984

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Lymphocytic populations and T cell subsets were studied in the blood of patients with nonleukemic non-Hodgkin lymphoma. A statistically significant decrease of both the T lymphocytes and the OKT4-, OKT8-binding cells was detected in low-grade malignant lymphomas (LGML). A significant decrease of the T cell population and of the OKT4-binding cells was also found in high-grade malignant lymphomas (HGML); in these, the OKT8-binding cells were not lowered. The amount of the circulating B lymphocytes was not found to be altered both in HGML and in LGML.

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B Lymphocytes in Untreated Patients with Malignant Lymphoma and Hodgkin's Disease

Cited by 64 publications

References 36 publications

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

B and T Cell Markers of Bone Marrow and Peripheral Blood Lymphoid Cells in Patients with Paraproteinaemia

Lymphocyte Populations and T Cell Subpopulations in Blood of Patients with Non-Hodgkin Lymphomas

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