B-type Natriuretic Peptide: Diagnostic and Therapeutic Applications in Infants and Children

Tobias, Joseph D.

doi:10.1177/0885066610387993

Cited by 10 publications

(11 citation statements)

References 80 publications

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“…Both ANP and BNP are abundantly expressed in the heart and are secreted mainly from the atria and ventricles, respectively. However, CNP is mainly expressed in the central nervous system, bone and vasculature (Nishikime et al, 2010;Tobias, 2011). Classically, the clearance of all NPs is carried out by NPR-C and by the neutral endopeptidase (NEP); both of these proteins are widely expressed in the kidneys, lungs and vascular walls (Chen and Burnett, 2006).…”

Section: Introductionmentioning

confidence: 99%

Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus)

Alves

Ximenes

Jorge

et al. 2013

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Mammalian natriuretic peptides (NPs) have been extensively investigated for use as therapeutic agents in the treatment of cardiovascular diseases. Here, we describe the isolation, sequencing and tridimensional homology modeling of the first C-type natriuretic peptide isolated from scorpion venom. In addition, its effects on the renal function of rats and on the mRNA expression of natriuretic peptide receptors in the kidneys are delineated. Fractionation of Tityus serrulatus venom using chromatographic techniques yielded a peptide with a molecular mass of 2190.64 Da, which exhibited the pattern of disulfide bridges that is characteristic of a C-type NP (TsNP, T. serrulatus Natriuretic Peptide). In the isolated perfused rat kidney assay, treatment with two concentrations of TsNP (0.03 and 0.1 μg/mL) increased the perfusion pressure, glomerular filtration rate and urinary flow. After 60 min of treatment at both concentrations, the percentages of sodium, potassium and chloride transport were decreased, and the urinary cGMP concentration was elevated. Natriuretic peptide receptor-A (NPR-A) mRNA expression was down regulated in the kidneys treated with both concentrations of TsNP, whereas NPR-B, NPR-C and CG-C mRNAs were up regulated at the 0.1 μg/mL concentration. In conclusion, this work describes the isolation and modeling of the first natriuretic peptide isolated from scorpion venom. In addition, examinations of the renal actions of TsNP indicate that its effects may be related to the activation of NPR-B, NPR-C and GC-C.

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Section: Introductionmentioning

confidence: 99%

Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus)

Alves

Ximenes

Jorge

et al. 2013

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“…Increased wall stress induces its release from the ventricular myocardium[14]. BNP levels predict re-hospitalization and death in pediatric patients who have decompensated heart failure[15].…”

Section: Introductionmentioning

confidence: 99%

Tissue Doppler Septal Tei Index Indicates Severity of Illness in Pediatric Patients With Congestive Heart Failure

et al. 2013

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Background: The Doppler Tei index is an independent predictor of outcomes in adult heart failure. Tissue Doppler imaging (TDI) may be a superior method to measure the Tei index in children, as it is less affected by heart rate variability. We hypothesized that the TDI Tei index reflects severity of illness in pediatric heart failure. Methods: Twenty-five pediatric heart failure patients were prospectively enrolled. Listing for heart transplantation or death were the outcomes used to define severity of illness. Baseline demographics, brain natriuretic peptide (BNP), standard echocardiographic and TDI-derived parameters were analyzed to determine outcome indicators. Results: Ten of the 25 patients (40%) were listed for transplantation. There were no deaths. Multivariate analysis combining age, heart rate, standard echocardiographic parameters, and BNP, resulted in shortening fraction (p=0.002) as the best indicator of listing for transplantation (R2 = 0.32). A second multivariate analysis combining age, heart rate, TDI parameters and BNP, resulted in age (p = 0.03) and septal Tei index (p = 0.03) as the best predictive model (R2 = 0.36). The area under the receiver operating characteristic (ROC) curve for septal Tei index was 0.84 (0.64-0.96, 95% confidence interval) and it was comparable to the ROC curve for shortening fraction, p=0.76. Optimal values of sensitivity (100%) and specificity (60%) were obtained with septal Tei index values > 0.51. Conclusion: The TDI septal Tei index is an indicator of disease severity in pediatric heart failure patients and offers potential advantages in comparison with standard echocardiographic measures of left ventricular ejection.

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“…BNP is a peptide extensively used as a marker for left heart function ( 34 ). Adults with GH deficiency have shown high BNP levels that do not decrease after short-term treatment ( 8 ), although knowledge about BNP use in GHD children is limited.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Evaluation of Left Ventricular Mass and Function in Children With Growth Hormone Deficiency After Replacement Treatment

et al. 2018

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Background: Our study was designed to assess the effects of GHD on nutritional and metabolic parameters, brain natriuretic peptide (BNP) levels, and left ventricular mass (LVM) in prepubertal children and after short-term GH replacement therapy.Materials and Methods: This prospective study enrolled 81 children. We compared 40 GHD children (16 males and 24 females) to 41 healthy children (control group) (18 males and 23 females). All subjects were at Tanner Stage I (aged 7–11 years). At the baseline, a blood sample was drawn and echocardiographic images were obtained. These tests were repeated on the GHD subjects after 6 months of GH replacement therapy. Body surface, weight, size, blood pressure, heart rate, glucose, insulin, HOMA-IR, HOMA-β, QUICKI, cholesterol, HDLc, LDLc, triglycerides, IGF1, and IGFBP3 were measured. Indexed LVM, diastolic and systolic diameter (dD-sD), diastolic and systolic LV function, isovolumic relaxation time, right ventricle function, and BNP levels were obtained through echocardiography. These parameters were correlated to growth factors. Data were analyzed using Student's t-test or U-Mann–Whitney-test and Pearson's correlation, considering p < 0.05 to be significant.Results: Indexed LVM was smaller in GHD patients than in controls, whereas diastolic and systolic functions, BNP, metabolic, and nutritional profiles were similar. After treatment, nutritional and metabolic profiles significantly improved, though diastolic and systolic functions did not seem to have changed. There was a significant increase in LVM. Indexed LVM was similar to that of controls. Significant correlations were obtained between LVM-IGF1 and sD-IGFBP3.Conclusions: GHD in childhood is associated with a lower indexed LVM. In the short-term, GH increases the indexed LVM, while maintaining normal systolic and diastolic functions, BNP, and an improved lipid profile.

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B-type Natriuretic Peptide: Diagnostic and Therapeutic Applications in Infants and Children

Cited by 10 publications

References 80 publications

Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus)

Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus)

Tissue Doppler Septal Tei Index Indicates Severity of Illness in Pediatric Patients With Congestive Heart Failure

Short-Term Evaluation of Left Ventricular Mass and Function in Children With Growth Hormone Deficiency After Replacement Treatment

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