B Vitamins Intake and Plasma Homocysteine in Vegetarians

Tsiami, Amalia; Obersby, Derek

doi:10.1016/b978-0-12-803968-7.00041-1

Cited by 3 publications

(5 citation statements)

References 71 publications

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“…The liver and kidneys are responsible for its clearance because of BHMT and CBS, which convert Hcy into nontoxic metabolites (Hannibal & Blom, 2017). In a healthy human, the Hcy level in plasma is from 5 to 15 µmol/L and the optimum level of tHcy is suggested to be <10 μmol/L (Tsiami & Obersby, 2017). According to Hcy level in plasma, HHcy is classified according to different levels: severe (>100 µmol/L), intermediate (31–100 µmol/L), and moderate (16–30 µmol/L) (Kostić et al., 2019).…”

Section: Homocysteine (Hcy) Role In the Bodymentioning

confidence: 99%

“…In humans, the only pathway for the biosynthesis of Hcy is from methionine (Ntaios, 2015). Hcy was discovered in 1932 by Butz and du Vigneaud when they heated methionine in sulfuric acid and obtained a substance with features similar to cysteine and named it “homocysteine (Hcy)” because it was a homolog of cysteine (Tsiami & Obersby, 2017). Hcy obtained through the methionine cycle as an intermediate product is catabolized through the transsulfuration pathway into cysteine (Ostrakhovitch & Tab ibzadeh, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Hcy exists in protein‐bound Hcy and free Hcy forms, and some of these two are referred to as total Hcy (tHcy). Hcy cannot be obtained from the diet since it is produced in the body from methionine which acts as a precursor of Hcy (Tsiami & Obersby, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…If the diet is rich in methionine, then the conversion of dietary methionine into SAM occurs, and as a result, CBS activation increases, and transculturation is dominated over remethylation. On the other hand, if the diet is low in methionine then SAM concentration is not enough for activation of CBS and the result is remethylation of Hcy promoted over transsulfuration (Tsiami & Obersby, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Cysteine and homocysteine as biomarker of various diseases

Rehman

Shabbir

Inam‐Ur‐Raheem

et al. 2020

Food Science & Nutrition

184

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Cysteine and homocysteine (Hcy), both sulfur‐containing amino acids (AAs), produced from methionine another sulfur‐containing amino acid, which is converted to Hcy and further converted to cysteine. This article aims to highlight the link between cysteine and Hcy, and their mechanisms, important functions, play in the body and their role as a biomarker for various types of diseases. So that using cysteine and Hcy as a biomarker, we can prevent and diagnose many diseases. This review concluded that hyperhomocysteinemia (elevated levels of homocysteine) is considered as toxic for cells and is associated with different health problems. Hyperhomocysteinemia and low levels of cysteine associated with various diseases like cardiovascular diseases (CVD), ischemic stroke, neurological disorders, diabetes, cancer like lung and colorectal cancer, renal dysfunction‐linked conditions, and vitiligo.

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Section: Homocysteine (Hcy) Role In the Bodymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cysteine and homocysteine as biomarker of various diseases

Rehman

Shabbir

Inam‐Ur‐Raheem

et al. 2020

Food Science & Nutrition

184

View full text Add to dashboard Cite

show abstract

“…Hcy is an essential α-amino acid formed when methionine is converted into cysteine with a total molecular mass of 135.18 g/mol. In humans, the production of serum Hcy is only possible from methionine [ 2 ]. Serum Hcy plays a major role in the human body as it contributes to many bodily functions [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Serum Homocysteine and Outcome in Patients With Traumatic Brain Injury

Amini¹,

Hewadmal²,

Rasuli³

et al. 2022

Cureus

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Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics

Taha

Mahdy-Abdallah

Shahy

et al. 2022

Journal of Complementary and Integrative Medicine

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Objectives Type 2 diabetes mellitus (T2DM) represents a serious public health problem. Environmental toxins, other than infectious agents or exposures can stimulate immune responses which are associated with the occurrence of T2DM. Diabetic nephropathy (DN) is a serious complication of diabetes that leads to changes in the structure and function of the kidneys. The study aimed to detect diagnostic biomarkers for (DN), at an early stage, to prevent disease progression in these patients and improve their outcomes. Methods This study was performed on 102 T2DM patients and 80 normal controls. Blood glucose, HbA1c, serum homocysteine (Hcy) and urinary periostin were assessed. Patients were divided into: controlled (n=46) (HbA1c <6.5%) and uncontrolled diabetics (n=56) (HbA1c >6.5%). Results The study results revealed a significant rise in blood glucose and HbA1c as well as serum Hcy levels in diabetic groups compared to controls. Also, urinary periostin exhibited significant elevation in diabetic groups. Serum glucose, HbA1c and serum Hcy revealed a highly significant difference between diabetic subgroups and control groups, while urinary periostin demonstrated a non-significant difference. Only, urinary periostin showed a significant increase in uncontrolled diabetics. Conclusions The highest levels of serum Hcy and urinary periostin were recorded only in the uncontrolled diabetics. Urinary periostin was demonstrated as a more preferable biomarker being a non-invasive sample for predicting renal insult in diabetic subjects. This biomarker could be performed regularly for early detection of DN. Also, it could be added to the periodic medical examinations of workers occupationally exposed to workplace pollutants inducing diabetes.

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B Vitamins Intake and Plasma Homocysteine in Vegetarians

Cited by 3 publications

References 71 publications

Cysteine and homocysteine as biomarker of various diseases

Cysteine and homocysteine as biomarker of various diseases

Role of Serum Homocysteine and Outcome in Patients With Traumatic Brain Injury

Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics

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