B18: A core XAS spectroscopy beamline for Diamond

Dent, A. J.; Cibin, Giannantonio; Ramos, Silvia; Smith, Andrew D.; Scott, Stewart M.; Varandas, L.; Pearson, M.; Krumpa, N.A.; Jones, C. P.; Robbins, Phil

doi:10.1088/1742-6596/190/1/012039

Cited by 155 publications

(127 citation statements)

References 6 publications

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“…45 The measurements were carried out using the Cr-coated branch of collimating and focusing mirrors and a Si(111) double-crystal monochromator. The size of the beam at the sample position was approximately 1 mm (h) Â 0.5 mm (v).…”

Section: Exafsmentioning

confidence: 99%

A molecular view of cisplatin's mode of action: interplay with DNA bases and acquired resistance

Marques

Gianolio

Cibin

et al. 2015

Phys. Chem. Chem. Phys.

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The interaction of the widely used anticancer drug cisplatin with DNA bases was studied by EXAFS and vibrational spectroscopy (FTIR, Raman and INS), coupled with DFT/plane-wave calculations. Detailed information was obtained on the local atomic structure around the Pt(II) centre, both in the cisplatinpurine (adenine and guanine) and cisplatin-glutathione adducts. Simultaneous neutron and Raman scattering experiments allowed us to obtain a reliable and definite picture of this cisplatin interplay with its main pharmacological target (DNA), at the molecular level. The vibrational experimental spectra were fully assigned in the light of the calculated pattern for the most favoured geometry of each drug-purine adduct, and cisplatin's preference for guanine (G) relative to adenine (A) within the DNA double helix was experimentally verified: a complete N by S substitution in the metal coordination sphere was only observed for [cDDP-A 2 ], reflecting a somewhat weaker Pt-A binding relative to Pt-G. The role of glutathione on the drug's pharmacokinetics, as well as on the stability of platinated DNA adducts, was evaluated as this is the basis for glutathione-mediated intracellular drug scavenging and in vivo resistance to Pt-based anticancer drugs. Spectroscopic evidence of the metal's preference for glutathione's sulfur over purine's nitrogen binding sites was gathered, at least two sulfur atoms being detected in platinum's first coordination sphere.

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Section: Exafsmentioning

confidence: 99%

A molecular view of cisplatin's mode of action: interplay with DNA bases and acquired resistance

Marques

Gianolio

Cibin

et al. 2015

Phys. Chem. Chem. Phys.

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“…Time resolved QEXAFS/UV-vis as well as freeze-quench experiments were performed at the B18 beamline 23 at Diamond Light Source in Didcot, England. A Si(111) double crystal was used in combination with ion chamber detectors for time-resolved transmission data and an Ortec® Ge 9 element Solid State detector for fluorescence acquisition on the frozen samples.…”

Section: Xafs Experimentationmentioning

confidence: 99%

“…Moreover, the freeze quench set-up now gives access to good quality EXAFS 5 second data, something which could not be obtained using QEXAFS (data quality of 1 s/spectrum QEXAFS data at SLS too low to allow EXAFS analysis, at Diamond QEXAFS data acquisition was [20][21][22][23][24][25][26][27][28][29][30] s/spectrum). or Lewis acid approach, with the Al-Cl versus Al-Br bond formations being the rate determining steps.…”

Section: Freeze-quench [Mobr 3 (Sbz)]mentioning

confidence: 99%

Insights in the mechanism of selective olefin oligomerisation catalysis using stopped-flow freeze-quench techniques: A Mo K-edge QEXAFS study

Bartlett

Wells

Nachtegaal

et al. 2011

Journal of Catalysis

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(2008) Probing the effects of ligand structure on activity and selectivity of Cr(III) complexes for ethylene oligomerisation and polymerization, Dalton Transactions, 1177-1185. (DOI: 10.1039 Stuart A. Bartlett, Giannantonio Cibin, Andrew J. Dent, John Evans, Martin J. Hanton, Gillian Reid, Robert P. Tooze, and Moniek Tromp, (2013) Sc(III) complexes with neutral N3-and SNS-donor ligands -a spectroscopic study of the activation of ethene polymerisation catalysts. Dalton Transactions, 42, (6), 2213Transactions, 42, (6), -2223Transactions, 42, (6), . (doi:10.1039 • Time-resolved and newly developed freeze-quench stopped flow XAS studies.• Stepwise displacement of halide observed, forming [Mo(CH 3 ) 3 (L)], without Mo dimers.• Reaction kinetics depending on metal and halide.• Decomposition of activated species to Mo precipitate. solutions within 1 second of mixing, opens up a large field of homogeneous catalysis and liquid chemistry to be studied, being able to quench at sub second time scales, while characterisation techniques with long data acquisition can be performed.

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“…Ce L III -edge X-ray absorption fine structure (XANES) experiments were performed using beamline B18 of the Diamond Light Source, UK [37]. This beamline provides X-ray energies in the range 2.05 -35 keV using a fixed-exit, double-crystal Si (111) monochromator, which provides an energy resolution ( E/E) of 2 10 4 .…”

Section: Methodsmentioning

confidence: 99%

Investigation of the hydrothermal crystallisation of the perovskite solid solution NaCe1−La Ti2O6 and its defect chemistry

Harunsani

Woodward

Peel

et al. 2013

Journal of Solid State Chemistry

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Keywords: Perovskite; hydrothermal; XANES; NMR; neutron diffraction 2 Graphical AbstractA multi-element A-site perovskite crystallises directly from aqueous, basic solutions at 240 ºC; while the paramagnetic effect of Ce 3+ on the 23 Na NMR shows a homogeneous solidsolution, the incorporation of A-site water is also found from 2 H NMR and IR, with oxidation of some cerium to charge balance proved by XANES spectroscopy.3

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B18: A core XAS spectroscopy beamline for Diamond

Cited by 155 publications

References 6 publications

A molecular view of cisplatin's mode of action: interplay with DNA bases and acquired resistance

A molecular view of cisplatin's mode of action: interplay with DNA bases and acquired resistance

Insights in the mechanism of selective olefin oligomerisation catalysis using stopped-flow freeze-quench techniques: A Mo K-edge QEXAFS study

Investigation of the hydrothermal crystallisation of the perovskite solid solution NaCe1−La Ti2O6 and its defect chemistry

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