Bacaba phenolic extract attenuates adipogenesis by down-regulating PPARγ and C/EBPα in 3T3-L1 cells

Lauvai, Judith; Schumacher, Monika; Finco, Fernanda Dias Bartolomeu Abadio; Graeve, Lutz

doi:10.1016/j.nfs.2017.09.001

Cited by 9 publications

(23 citation statements)

References 51 publications

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“…(81.86 to 363.01 mg GAE 100 g -1 db) and for other fruits native to the Amazon region, such as inajá (109.75 mg GAE 100 g -1 ), tucumã (127.27 mg GAE 100 g -1 ) (Santos et al, 2015), bacuri (521 mg GAE 100 g -1 ), cupuaçu (305 mg GAE 100 g -1 ) and abiu (430 mg GAE 100 g -1 ) (Becker et al, 2018). Like flavonoids and anthocyanins, polyphenols help as antioxidants by reducing the action of free radicals, as well as acting in other systems as supporting elements in the prevention of human health problems (Finco et al, 2016;Lauvai et al, 2017;Nascimento et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…The consumption of this fruit is predominantly in the form of a drink, which is produced and consumed similarly to that of açaí (Euterpe oleracea Mart. ), with these fruits competing commercially due to their off-season (Finco et al, 2016;Lauvai et al, 2017;Pinto et al, 2018;Nascimento et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The different genotypes of bacaba have been the focus of research, particularly in the evaluation of antioxidant activity and phenolic compounds, in natura, as in the research of Carvalho et al (2016) and Brabo de Sousa et al (2018), as well as the investigation of extracts in the induction of apoptosis and cell adipogenesis as a novel cancer treatment (Finco et al, 2016;Lauvai et al, 2017). In the industrial segment, studies have concentrated on the isolation of its energy constituents, lipid content and residual oils using gases in a supercritical state (Pinto et al, 2018;Nascimento et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Industrial potential of Bacaba (Oenocarpus bacaba) in powder: antioxidant activity, spectroscopic and morphological behavior

et al. 2022

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The objective of this research was to analyze the industrial potential of a bacaba powder (Oenocarpus bacaba) obtained by different drying methods, evaluating antioxidant activity, spectroscopic and morphological behavior and addition to the composition of inorganic elements. The content of anthocyanins, flavonoids and carotenoids of each powder were determined as well as the total phenolic compounds. The structure of the granules of the powder were visualized via scanning electron microscopy (SEM) and the elemental composition was attained by the X-ray spectroscopic energy dispersive system (EDS). The data suggest that the freeze-drying method is more efficient in obtaining the bacaba powder material. The increase in temperature applied in the convection drying process caused a reduction in the bioactive compound content and elements with antioxidant activity, it severely damaged the morphology of the plant membrane and influenced the composition of the spectral bands. Thus, this study indicates that the freezer-drying method could be particularly useful for obtaining bacaba powder in off-season periods, and that bacaba itself is a raw material that could be exploited by several industrial segments.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Industrial potential of Bacaba (Oenocarpus bacaba) in powder: antioxidant activity, spectroscopic and morphological behavior

et al. 2022

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“…4). Consistently, many compounds or extracts were reported to effectively inhibit adipogenesis when they were incubated with the differentiating cells from the beginning [45][46][47][48] . These results suggest that many adipogenic inhibitors may share a common target, which is probably active during the early stage of adipogenesis.…”

Section: Mechanism Of Lcb Inducing An Inflammatory Response and Adipogenic Inhibition In Differentiating 3t3-l1 Adipocytesmentioning

confidence: 69%

Mechanism of the fungal-like particles in the inhibition of adipogenesis in 3T3-L1 adipocytes

Jakkawanpitak

Inafuku

Oku

et al. 2021

Sci Rep

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The dynamic ability of adipocytes in adipose tissue to store lipid in response to changes in the nutritional input and inflammatory elicitors has a major impact on human health. Previously, we established laminarin-coated beads or LCB as an inflammatory elicitor for adipocytes. However, it was not clear whether LCB inhibits lipid accumulation in adipocytes. Here, we show that LCB acts in the early stage of adipogenesis through both interleukin-1 receptor-associated kinases (IRAK) and spleen tyrosine kinase (SYK) pathways, resulting in the activation of the AMP-activated protein kinase (AMPK) and nuclear factor-κB (NF-κB) complexes, which subsequently cause cell cycle arrest, downregulation of the key transcription factors and enzymes responsible for adipogenesis, inhibition of adipogenesis, and stimulation of an inflammatory response. While LCB could effectively block lipid accumulation during the early stage of adipogenesis, it could stimulate an inflammatory response at any stage of differentiation. Additionally, our results raise a possibility that toll-like receptor 2 (TLR2) and C-type lectin domain family 7 member A (CLEC7A/Dectin-1) might be potential β-glucan receptors on the fat cells. Together, we present the mechanism of LCB, as fungal-like particles, that elicits an inflammatory response and inhibits adipogenesis at the early stage of differentiation.

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“… Leba et al (2014) Pulp phenolic extract Phenolic compounds In vitro cell culture (3T3-L1 preadipocytes) Reduced accumulation of intracellular lipids and protein expression of adipogenic markers including PPARγ, C/EBPα, FABP4, IR-β, and adiponectin; decreased lipid accumulation; adipogenesis inhibition. Lauvai et al (2017) Buriti ( Mauritia flexuosa ) Freeze–dried pulp Carotenoids In vitro Antioxidant properties. Berni et al (2020) Leaves extracts Flavonoids: tricin-7-O-rutinoside, apigenin-6-C-arabinoside, 8-Cglucoside, kaempferol-3-O-rutinoside, quercetin-3-O-rutinoside, luteolin-8-C-glucoside and luteolin-6-C-glucoside.…”

Section: Potential Effects Of Amazonian Fruits and Oilseeds To Streng...mentioning

confidence: 99%

Nutraceutical potential of Amazonian oilseeds in modulating the immune system against COVID-19 – A narrative review

Santos

Langley

Lima

et al. 2022

Journal of Functional Foods

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Bacaba phenolic extract attenuates adipogenesis by down-regulating PPARγ and C/EBPα in 3T3-L1 cells

Cited by 9 publications

References 51 publications

Industrial potential of Bacaba (Oenocarpus bacaba) in powder: antioxidant activity, spectroscopic and morphological behavior

Industrial potential of Bacaba (Oenocarpus bacaba) in powder: antioxidant activity, spectroscopic and morphological behavior

Mechanism of the fungal-like particles in the inhibition of adipogenesis in 3T3-L1 adipocytes

Nutraceutical potential of Amazonian oilseeds in modulating the immune system against COVID-19 – A narrative review

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