Bacillus and Paenibacillus secreted polyketides and peptides involved in controlling human and plant pathogens

Olishevska, Snizhana; Nickzad, Arvin; Déziel, Éric

doi:10.1007/s00253-018-9541-0

Cited by 100 publications

(66 citation statements)

References 139 publications

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“…Polyketide biosynthesis is performed by successive condensation of small carboxylic acids mediated by core domains of the corresponding enzyme machinery but some PKs are synthesized via hybrid NRPS/PKS systems leading to the integration of amino acid residues (Piel, 2010;Olishevska et al, 2019). The three main PKs produced by Bacillus are difficidins, macrolactins, and bacillaenes, the latter being more widespread across species (Figure 1).…”

Section: Diversity and Bioactivities Of Bacillus Bsmsmentioning

confidence: 99%

“…The three main PKs produced by Bacillus are difficidins, macrolactins, and bacillaenes, the latter being more widespread across species (Figure 1). The main PKs role is related to their antibacterial activity via the ability to inhibit protein biosynthesis in numerous phytopathogenic bacteria but certain antifungal activity has been reported for bacillaenes and macrolactins (Caulier et al, 2019;Olishevska et al, 2019).…”

Section: Diversity and Bioactivities Of Bacillus Bsmsmentioning

confidence: 99%

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Bacillus Responses to Plant-Associated Fungal and Bacterial Communities

2020

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Some members of root-associated Bacillus species have been developed as biocontrol agents due to their contribution to plant protection by directly interfering with the growth of pathogens or by stimulating systemic resistance in their host. As rhizosphere-dwelling bacteria, these bacilli are surrounded and constantly interacting with other microbes via different types of communications. With this review, we provide an updated vision of the molecular and phenotypic responses of Bacillus upon sensing other rhizosphere microorganisms and/or their metabolites. We illustrate how Bacillus spp. may react by modulating the production of secondary metabolites, such as cyclic lipopeptides or polyketides. On the other hand, some developmental processes, such as biofilm formation, motility, and sporulation may also be modified upon interaction, reflecting the adaptation of Bacillus multicellular communities to microbial competitors for preserving their ecological persistence. This review also points out the limited data available and a global lack of knowledge indicating that more research is needed in order to, not only better understand the ecology of bacilli in their natural soil niche, but also to better assess and improve their promising biocontrol potential.

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Section: Diversity and Bioactivities Of Bacillus Bsmsmentioning

confidence: 99%

Section: Diversity and Bioactivities Of Bacillus Bsmsmentioning

confidence: 99%

Bacillus Responses to Plant-Associated Fungal and Bacterial Communities

2020

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“…Currently, there is considerable interest in the expression of bacteriocins in plant cells. Recent research shows that this group of proteins seems to have a unique potential especially as a viable alternative to antibiotics or new food processing aids (Hahn-Löbmann et al 2019;Olishevska et al 2019;Schneider et al 2018;Paškevičius et al 2017). Moreover colicin-like bacteriocins in plants could mediate resistance to bacteria in plants, however this has yet to be unveiled (Li et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Production of recombinant colicin M in Nicotiana tabacum plants and its antimicrobial activity

Łojewska

Sakowicz

Kowalczyk

et al. 2019

Plant Biotechnol Rep

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Antibiotic-resistant microorganisms causing a life-threatening infection pose a serious challenge for modern science. The rapidly growing number of incidents for which the use of standard antibiotics is ineffective forces us to develop new alternative methods of killing microorganisms. Antimicrobial proteins and peptides (AMPs) can be promising candidates to solve this problem. Colicin-M is one of the representatives of this group and is naturally produced by Escherichia coli acting on other closely related bacterial strains by disrupting their outer cell membrane. This bacteriocin has huge potential as a potent antimicrobial agent, especially, since it was recognized by the FDA as safe. In this work, we present the expression of colicin M in model transgenic Nicotiana tabacum L. plants. We demonstrate that purified colicin retains its antibacterial activity against the control Escherichia coli strains and clinical isolates of Escherichia coli and Klebsiella pneumoniae. Our results also show that plant-derived ColM is not toxic for L929 and HeLa cell line, which allows us to suppose that plant-based expression could be an alternative production method of such important proteins.

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“…Polyketides are a large group of natural products built from acyl-coenzyme A, essential for bacterial antagonism. Many PK produced by Bacillus are bactericidal agents that play a vital role in controlling plant pathogens [84][85]. Regarding B. subtilis PTA-271 genome ( Supplementary Table S7), 15 genes encode for PKS and many others for acetyltransferases or share similar part of the PKS functions.…”

Section: 4-direct Confrontation With Pathogens or Aggressive Molecmentioning

confidence: 99%

Genome sequence analysis of the beneficial Bacillus subtilis PTA-271 isolated from a Vitis vinifera (cv. Chardonnay) rhizospheric soil: assets for sustainable biocontrol.

Leal

Fontaine

Aziz

et al. 2020

Preprint

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Background: Bacillus subtilis strains have been widely studied for their innumerous benefits in agriculture, including viticulture. Providing numerous assets, B. subtilis spp. are described as promising plant-protectors against many pathogens and as influencers to adaptations in a changing environment. This study reports the draft genome sequence of the beneficial Bacillus subtilis PTA-271, isolated from the rhizospheric soil of healthy Vitis vinifera cv. Chardonnay at Champagne Region in France, attempting to draw outlines of its full biocontrol capacity. Results: The PTA-271 genome has a size of 4,001,755 bp, with 43.78% of G + C content and 3,945 protein coding genes. The draft genome of PTA-271 highlights (1) a functional swarming motility system hypothesizing a colonizing capacity and a strong interacting capacity, (2) strong survival capacities and (3) a set of genes encoding for bioactive substances. Bioactive compounds are known both to (i) stimulate plant growth or defenses such as hormones and elicitors, (ii) influence beneficial microbiota, and (ii) counteract pathogen aggressiveness such as effectors and many kinds of detoxifying enzymes. Conclusions: The plurality of the encoded biomolecules by Bacillus subtilis PTA-271 genome appears as strengths for PTA-271 biocontrol potential towards plants, offering a big potential against a broad spectrum of pathogens despite environmental constraints.

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Bacillus and Paenibacillus secreted polyketides and peptides involved in controlling human and plant pathogens

Cited by 100 publications

References 139 publications

Bacillus Responses to Plant-Associated Fungal and Bacterial Communities

Bacillus Responses to Plant-Associated Fungal and Bacterial Communities

Production of recombinant colicin M in Nicotiana tabacum plants and its antimicrobial activity

Genome sequence analysis of the beneficial Bacillus subtilis PTA-271 isolated from a Vitis vinifera (cv. Chardonnay) rhizospheric soil: assets for sustainable biocontrol.

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